Simon E. Wink
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View article: Iron chelation prior to static cold storage decreases lipid peroxidation and improves gluconeogenesis during NMP in isolated porcine kidneys
Iron chelation prior to static cold storage decreases lipid peroxidation and improves gluconeogenesis during NMP in isolated porcine kidneys Open
Despite alternative graft preservation techniques, static cold storage (SCS) remains the most widely used kidney preservation method. Nevertheless, the molecular mechanisms of SCS' drawbacks remain poorly understood. One of the mechanisms …
Targeting the Electron Transport System for Enhanced Longevity Open
Damage to mitochondrial DNA (mtDNA) results in defective electron transport system (ETS) complexes, initiating a cycle of impaired oxidative phosphorylation (OXPHOS), increased reactive oxygen species (ROS) production, and chronic low-grad…
Glomerular and tubular effects of dapagliflozin, eplerenone and their combination in patients with chronic kidney disease: A post‐hoc analysis of the <span>ROTATE</span> ‐3 study Open
Aim Sodium‐glucose co‐transporter 2 inhibitors and mineralocorticoid receptor antagonists reduce albuminuria and the risk of kidney failure. The aim of this study was to investigate the effects of both agents alone and in combination on ma…