Simon Felder
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View article: Functional Proximity across an mRNA
Functional Proximity across an mRNA Open
Extensive RNA-protein interactions occur throughout the lifecycle of an mRNA that up- and down-regulate mRNA translation and degradation. Modulating interactions between regulatory proteins and mRNAs can have large effects on gene expressi…
View article: <i>fpocketR</i> : A platform for identification and analysis of ligand-binding pockets in RNA
<i>fpocketR</i> : A platform for identification and analysis of ligand-binding pockets in RNA Open
Small molecules that bind specific sites in RNAs hold promise for altering RNA function, manipulating gene expression, and expanding the scope of druggable targets beyond proteins. Identifying binding sites in RNA that can engage ligands w…
View article: Protein binding in an mRNA 5′-UTR sterically hinders translation
Protein binding in an mRNA 5′-UTR sterically hinders translation Open
Structures in the 5′ untranslated regions (UTRs) of mRNAs can physically modulate translation efficiency by impeding the scanning ribosome or by sequestering the translational start site. We assessed the impact of stable protein binding in…
View article: [2.2]Paracyclophanes: From Selective Functionalization to Optical Properties
[2.2]Paracyclophanes: From Selective Functionalization to Optical Properties Open
Since their discovery, [2.2]paracyclophane (pCp) and its derivatives have fascinated the scientific community due to their original molecular architecture and unusual electronic behavior. Over the years, significant efforts have been devot…
View article: Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives
Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives Open
This perspective discusses the synthesis and (chir)optical properties of compact luminophores derived from [2.2]paracyclophane useful as building blocks for the development of CPL emitters.
View article: Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping
Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping Open
Targeting RNAs with small molecules is considered the next frontier for drug discovery. In this context, the development of compounds capable of binding RNA structural motifs of low complexity with high affinity and selectivity would great…
View article: Planar Chiral Analogues of PRODAN Based on a [2.2]Paracyclophane Scaffold: Synthesis and Photophysical Studies
Planar Chiral Analogues of PRODAN Based on a [2.2]Paracyclophane Scaffold: Synthesis and Photophysical Studies Open
We describe the synthesis and photophysical characterization of differently substituted planar chiral analogues of PRODAN based on a [2.2]paracyclophane scaffold. This experimental and theoretical study highlights that the (chir)optical pr…
View article: Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis
Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis Open
This short review focuses on enantiopure planar chiral [2.2]paracyclophanes (pCps), a fascinating class of molecules that possess an unusual three‐dimensional core and intriguing physicochemical properties. In the first part of the review,…
View article: Para‐Functionalization of N‐Substituted 4‐amino[2.2]paracyclophanes by Regioselective Formylation
Para‐Functionalization of N‐Substituted 4‐amino[2.2]paracyclophanes by Regioselective Formylation Open
Herein, we report a simple and convenient procedure to prepare para ‐disubstituted [2.2]paracyclophanes in a straightforward manner. Our approach relies on a regioselective formylation of N‐substituted 4‐amino[2.2]paracyclophanes, which al…
View article: CCDC 1535011: Experimental Crystal Structure Determination
CCDC 1535011: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …