Simon Fristed Eskildsen
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View article: Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders
Porcine model of <i>BRD1</i> haploinsufficiency reveals neurodevelopmental, behavioral, and molecular alterations relevant to psychiatric disorders Open
Psychiatric disorders are heritable and biologically complex, with overlapping genetic architectures and shared molecular pathways. Among implicated genes, BRD1 has emerged as an epigenetic regulator of neurodevelopment with broad relevanc…
View article: Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry
Easy-to-use and easy-to-interpret quality control of 3D gradient echo T1-weighted MR acquisition sequences for improved test-retest stability of MRI-based hippocampus volumetry Open
Background MRI-based hippocampus volume (HV) is widely used as neurodegeneration marker in Alzheimer's disease. Objective An easy-to-use and easy-to-interpret method to categorize T1-weighted MR sequences with respect to test-retest stabil…
View article: Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns
Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns Open
NCT03322761, NCT02661555, NCT04762342, NCT04356248, DRKS00017091, DRKS00031445, DRKS00028792, DRKS00029105.
View article: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
Missense variants in the O-GlcNAc transferase (OGT) gene have recently been shown to segregate with a syndromic form of intellectual disability (OGT-ID), underscoring the importance of protein O-GlcNAcylation in brain function. However, th…
View article: Author response: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Author response: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
View article: Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity
Pathogenic O-GlcNAc dyshomeostasis associated with cortical malformations and hyperactivity Open
Missense variants in the O-GlcNAc transferase (OGT) gene have recently been shown to segregate with a syndromic form of intellectual disability (OGT-ID), underscoring the importance of protein O-GlcNAcylation in brain function. However, th…
View article: Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study
Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study Open
Neuroaxonal damage in multiple sclerosis (MS) results from an interplay of neurotoxic pathomechanisms combined with a reduced neuroprotective capacity of neurons and glia to resist neurotoxic damage. Kynurenine pathway (KP) imbalance resem…
View article: Estimation of oxygen extraction fraction based on hemodynamic measurements using DSC-MRI
Estimation of oxygen extraction fraction based on hemodynamic measurements using DSC-MRI Open
Oxygen availability in brain tissue is closely linked to local hemodynamics and even slight disturbances in the cerebral microcirculation may damage cells due to the brain’s high energy demands. In addition to local cerebral blood flow, kn…
View article: The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI
The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI Open
The locus coeruleus (LC) produces most of the brain’s noradrenaline (NA). Among its many roles, NA is often said to be neuroprotective and important for brain upkeep. For this reason, loss of LC integrity is thought to impact brain volume …
View article: Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease
Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease Open
INTRODUCTION Microglial responses are an integral part of Alzheimer's disease (AD) pathology and are associated with amyloid beta (Aβ) deposition. This study aimed to investigate the effects of Aβ and microglial responses on global cogniti…
View article: Hypoparathyroidism: changes in brain structure, cognitive impairment, and reduced quality of life
Hypoparathyroidism: changes in brain structure, cognitive impairment, and reduced quality of life Open
Hypoparathyroidism (HypoPT) is a disease with no/or inadequate production/secretion of parathyroid hormone (PTH) from the parathyroid glands. Low levels of PTH result in hypocalcemia, which is often treated with calcium supplementation and…
View article: Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the “power training in older multiple sclerosis patients (PoTOMS) randomized control trial
Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the “power training in older multiple sclerosis patients (PoTOMS) randomized control trial Open
The presented study is approved by The Regional Ethics Committee (reference number 1-10-72-222-20) and registered at the Danish Data Protection Agency (reference number 2016-051-000001). All study findings will be published in scientific p…
View article: Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment Open
View article: Differentiation of MS lesions through analysis of microvascular distribution
Differentiation of MS lesions through analysis of microvascular distribution Open
Conventional MRI is crucial for diagnosing multiple sclerosis (MS) but lacks precision, leading to the clinico-radiological paradox and misdiagnosis risk, especially when confronted with unspecific lesions not related to MS. Advancements i…
View article: Capillary dysfunction in healthy elderly <i>APOE ε</i>4 carriers with raised brain Aβ deposition
Capillary dysfunction in healthy elderly <i>APOE ε</i>4 carriers with raised brain Aβ deposition Open
INTRODUCTION Capillary dysfunction, characterized by disturbances in capillary blood flow distribution, might be an overlooked factor in the development of Alzheimer's disease (AD). This study investigated microvascular blood flow in precl…
View article: Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease
Performance on complex memory tests is associated with β‐amyloid in individuals at risk of developing Alzheimer's disease Open
The pathophysiological development of Alzheimer's disease (AD) begins in the brain years before the onset of clinical symptoms. The accumulation of beta‐amyloid (Aβ) is thought to be the first cortical pathology to occur. Carrying one apol…
View article: Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer’s Disease
Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer’s Disease Open
Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ scores in two delaye…
View article: Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease
Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease Open
View article: Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood
Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood Open
Background Delayed brain development, brain injury, and neurodevelopmental disabilities are commonly observed in infants operated for complex congenital heart defect. Our previous findings of poorer neurodevelopmental outcomes in individua…
View article: Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study Open
View article: Capillary Dysfunction Correlates with Cortical Amyloid Load in Early Alzheimer's Disease
Capillary Dysfunction Correlates with Cortical Amyloid Load in Early Alzheimer's Disease Open
View article: Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis—An Explorative Study
Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis—An Explorative Study Open
Objective: Persons with multiple sclerosis (PwMS), already established as responders or non-responders to Fampridine treatment, were compared in terms of disability measures, physical and cognitive performance tests, neurophysiology, and m…
View article: Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder
Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder Open
In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capi…
View article: Abnormal Left‐Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood
Abnormal Left‐Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood Open
Background Children operated on for a simple congenital heart defect (CHD) are at risk of neurodevelopmental abnormalities. Abnormal cortical development and folding have been observed in fetuses with CHD. We examined whether sulcal foldin…
View article: Dairy-Derived Emulsifiers in Infant Formula Show Marginal Effects on the Plasma Lipid Profile and Brain Structure in Preterm Piglets Relative to Soy Lecithin
Dairy-Derived Emulsifiers in Infant Formula Show Marginal Effects on the Plasma Lipid Profile and Brain Structure in Preterm Piglets Relative to Soy Lecithin Open
Breastfed infants have higher intestinal lipid absorption and neurodevelopmental outcomes compared to formula-fed infants, which may relate to a different surface layer structure of fat globules in infant formula. This study investigated i…
View article: Infants with congenital heart defects have reduced brain volumes
Infants with congenital heart defects have reduced brain volumes Open
View article: Impaired cerebral microcirculation in isolated REM sleep behaviour disorder
Impaired cerebral microcirculation in isolated REM sleep behaviour disorder Open
During the prodromal period of Parkinson’s disease and other α-synucleinopathy-related parkinsonisms, neurodegeneration is thought to progressively affect deep brain nuclei, such as the locus coeruleus, caudal raphe nucleus, substantia nig…
View article: Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES)
Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES) Open
Introduction In the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting the long-term impact of the disease. Medical disease-modifying treatments have proven effective, especial…
View article: Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis
Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis Open
This study provides Level I evidence that 24 weeks of high-intensity PAE did not elicit disease-modifying effects in PBVC in people with MS. Exploratory analyses showed that PAE may reduce relapse rate.
View article: A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis – An explorative study
A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis – An explorative study Open