Simon Gissing
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View article: Unsaturated fatty acids identified as reversible soluble guanylyl cyclase inhibitors
Unsaturated fatty acids identified as reversible soluble guanylyl cyclase inhibitors Open
As key enzyme in the NO/cGMP pathway, soluble guanylyl cyclase (sGC) has become an important therapeutic target in the treatment of cardiovascular diseases. In addition to activating compounds, inhibitors of sGC are necessary tools in rese…
View article: An adenosinergic positive feedback loop extends pharmacological cardioprotection duration
An adenosinergic positive feedback loop extends pharmacological cardioprotection duration Open
Background and Purpose Adenosine receptor activation induces delayed, sustained cardioprotection against ischaemia–reperfusion (IR) injury (24–72 h), but the mechanisms underlying extended cardioprotection duration remain unresolved. We hy…