Simon Granak
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View article: Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia
Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia Open
Mild hypoxic-ischaemic encephalopathy is common in neonates, and there are no evidence-based therapies. By school age, 30–40% of those patients experience adverse neurodevelopmental outcomes. The nature and progression of mild injury is po…
View article: Ongoing loss of viable neurons for weeks after mild perinatal hypoxia-ischemia
Ongoing loss of viable neurons for weeks after mild perinatal hypoxia-ischemia Open
Mild hypoxic-ischemic encephalopathy is common in neonates with no evidence-based therapies, and 30-40% of patients experience adverse outcomes. The nature and progression of mild injury is poorly understood. Thus, we studied the evolution…
View article: Region-specific spreading depolarization drives aberrant post-ictal behavior
Region-specific spreading depolarization drives aberrant post-ictal behavior Open
Summary Confusion, aphasia, and unaware wandering are prominent post-ictal symptoms regularly observed in temporal lobe epilepsy (TLE) 1 . Despite the potentially life-threatening nature of the immediate post-ictal state 2 , its neurobiolo…
View article: Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases Open
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level o…
View article: The impact of constitutive mTORC1 hyperactivity on structural synaptic plasticity and social behaviour under standard conditions and environmental enrichment
The impact of constitutive mTORC1 hyperactivity on structural synaptic plasticity and social behaviour under standard conditions and environmental enrichment Open
Introduction Autism spectrum disorders (ASD) are a group of neurodevelopmental disabilities causing major social, communication, and behavioural challenges. Although causative roles of altered genes and environment are recognized, the unde…