Simon H. Apte
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View article: Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise
Silicosis research priorities for health care, research, and health and safety professionals, and for people exposed to silica in Australia: a research priority setting exercise Open
Objectives To identify the silicosis research priorities of people living with silicosis, workers at risk of silicosis, their partners and caregivers, and of health professionals and researchers. Study design Research priority setting exer…
View article: Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development
Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development Open
Alveolar macrophages (AM) must perform three seemingly opposing roles including homeostasis, driving inflammation, and facilitating tissue repair. Whilst there is now consensus (supported by a large body of human single cell RNA sequencing…
View article: Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development
Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development Open
Alveolar macrophages (AM) must perform three seemingly opposing roles including homeostasis, driving inflammation, and facilitating tissue repair. Whilst there is now consensus (supported by a large body of human single cell RNA sequencing…
View article: Lung Transplantation for Short-Telomere Interstitial Lung Disease: Outcomes from an Australian Cohort
Lung Transplantation for Short-Telomere Interstitial Lung Disease: Outcomes from an Australian Cohort Open
View article: Immunological Landscapes in Lung Transplantation: Insights from T Cell Profiling in BAL and PBMC
Immunological Landscapes in Lung Transplantation: Insights from T Cell Profiling in BAL and PBMC Open
Lung transplant recipients frequently encounter immune-related complications, including chronic lung allograft dysfunction (CLAD). Monitoring immune cells within the lung microenvironment is pivotal for optimizing post-transplant outcomes.…
View article: A Methodological Approach to Identify Natural Compounds with Antifibrotic Activity and the Potential to Treat Pulmonary Fibrosis Using Single-Cell Sequencing and Primary Human Lung Macrophages
A Methodological Approach to Identify Natural Compounds with Antifibrotic Activity and the Potential to Treat Pulmonary Fibrosis Using Single-Cell Sequencing and Primary Human Lung Macrophages Open
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of the interstitial pneumonias. The cause of the disease is unknown, and new therapies that stop or reverse disease progression are desperately needed. Recent advances …
View article: Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study
Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study Open
This study investigated immune cell characteristics in chronic hypersensitivity pneumonitis (HP), focusing on CD39-expressing cells’ impact on inflammation and tissue remodelling. Lung tissue from an HP patient was analysed using single-ce…
View article: Markers of Rejection of A Lung Allograft: State of the Art
Markers of Rejection of A Lung Allograft: State of the Art Open
Chronic lung allograft dysfunction (CLAD) affects approximately 50% of all lung transplant recipients by 5 post-operative years and is the leading cause of death in lung transplant recipients. Early CLAD diagnosis or ideally prediction of …
View article: Alveolar crystal burden in stone workers with artificial stone silicosis
Alveolar crystal burden in stone workers with artificial stone silicosis Open
Background and objective An epidemic of silicosis has emerged due to a failure to control risks associated with exposure to high‐silica content respirable dust generated while working with artificial stone products. Methods for quantificat…
View article: TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis Open
Introduction Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens, including danazol, may be effective in lengthening telomeres in …
View article: Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection
Proteomic identification of the contents of small extracellular vesicles from in vivo Plasmodium yoelii infection Open
View article: Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses
Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses Open
Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) ar…
View article: Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol Open
We report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure. Given a…
View article: Pulmonary alveolar proteinosis after lung transplantation
Pulmonary alveolar proteinosis after lung transplantation Open
We report the case of a 69‐year‐old man five‐month post double lung transplant for idiopathic pulmonary fibrosis (IPF) who presented with progressive breathlessness, loss of lung function, and diffuse ground glass shadowing on the chest co…
View article: A population of CD4<sup>hi</sup>CD38<sup>hi</sup> T cells correlates with disease severity in patients with acute malaria
A population of CD4<sup>hi</sup>CD38<sup>hi</sup> T cells correlates with disease severity in patients with acute malaria Open
Objective CD4 + T cells are critical mediators of immunity to Plasmodium spp. infection, but their characteristics during malarial episodes and immunopathology in naturally infected adults are poorly defined. Flow cytometric analysis of PB…
View article: <i>SMG1</i> heterozygosity exacerbates haematopoietic cancer development in <i>Atm</i> null mice by increasing persistent DNA damage and oxidative stress
<i>SMG1</i> heterozygosity exacerbates haematopoietic cancer development in <i>Atm</i> null mice by increasing persistent DNA damage and oxidative stress Open
Suppressor of morphogenesis in genitalia 1 (SMG1) and ataxia telangiectasia mutated (ATM) are members of the PI3‐kinase like–kinase (PIKK) family of proteins. ATM is a well‐established tumour suppressor. Loss of one or both alleles of ATM …
View article: Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses
Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses Open
An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, bu…
View article: Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties
Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties Open
Plant-derived compounds that modulate the immune responses are emerging as frontline treatment agents for cancer, infectious diseases and autoimmunity. Herein we have isolated 40 phytochemicals from five Bhutanese Sowa Rigpa medicinal plan…
View article: Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses
Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses Open
The development of vaccines against complex intracellular pathogens, such as Plasmodium spp ., where protection is likely mediated by cellular immune responses, has proven elusive. The availability of whole genome, proteome and transcripto…
View article: Dichotomous miR expression and immune responses following primary blood-stage malaria
Dichotomous miR expression and immune responses following primary blood-stage malaria Open
Clinical responses to infection or vaccination and the development of effective immunity are characterized in humans by a marked interindividual variability. To gain an insight into the factors affecting this variability, we used a control…
View article: Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct
Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct Open
Pathogen-specific polyfunctional T cell responses have been associated with favorable clinical outcomes, but it is not known whether molecular differences exist between polyfunctional and monofunctional cytokine-producing T cells. Here, we…
View article: Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential
Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential Open
anzctr.org.au ACTRN12612000814875; anzctr.org.au ACTRN12613000565741; anzctr.org.au ACTRN12613001040752; ClinicalTrials.gov NCT02281344; anzctr.org.au ACTRN12612001096842; anzctr.org.au ACTRN12613001008718.
View article: Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production
Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production Open
ClinicalTrials.gov clinical trial numbers ACTRN12612000814875, ACTRN12613000565741 and ACTRN12613001040752.
View article: Quantitative assessment of the functional plasticity of memory CD8<sup>+</sup> T cells
Quantitative assessment of the functional plasticity of memory CD8<sup>+</sup> T cells Open
While the functional plasticity of memory CD4 + T cells has been studied extensively, less is known about this property in memory CD8 + T cells. Here, we report the direct measurement of plasticity by paired daughter analysis of effector a…
View article: Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria
Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria Open
Background: Malaria, caused by the protozoan parasite Plasmodium, is one of the main causes of morbidity and mortality of the whole human population.Intensive, ongoing research aims to develop an effective vaccine against malaria; however,…
View article: Parasite burden and parasitemia following vaccination and infection.
Parasite burden and parasitemia following vaccination and infection. Open
Mice were vaccinated s.c. three times at three week intervals with lipid core peptides (LCP), or pooled peptides (P1, P2, P3, P4; see Table 1) and CpG-Alum, or i.m. injection with DNA vaccine encoding PyCSP. Seven days after …