Simon H. Bridge
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View article: Autoantibodies to apolipoprotein A-I in hepatitis C virus infection: a role in disease progression?
Autoantibodies to apolipoprotein A-I in hepatitis C virus infection: a role in disease progression? Open
Background Chronic HCV (CHC) infection is associated with autoimmunity. IgG autoantibodies to apolipoprotein A-I (AAA-I) predict all-cause mortality. We evaluated AAA-I in CHC patients and in those who were not viraemic, either because of …
View article: The core phageome and its interrelationship with preterm human milk lipids
The core phageome and its interrelationship with preterm human milk lipids Open
Phages and lipids in human milk (HM) may benefit preterm infant health by preventing gastrointestinal pathobiont overgrowth and microbiome modulation. Lipid association may promote vertical transmission of phages to the infant. Despite thi…
View article: Optimisation and Application of a Novel Method to Identify Bacteriophages in Maternal Milk and Infant Stool Identifies Host-Phage Communities Within Preterm Infant Gut
Optimisation and Application of a Novel Method to Identify Bacteriophages in Maternal Milk and Infant Stool Identifies Host-Phage Communities Within Preterm Infant Gut Open
Human milk oligosaccharides, proteins, such as lactoferrin, and bacteria represent just some of the bioactive components of mother's breast milk (BM). Bacteriophages (viruses that infect bacteria) are an often-overlooked component of BM th…
View article: Lipidomics and body fat composition analysis characterises specific differences in cholesterol metabolism and steatosis between hepatitis C virus genotypes 1 and 3
Lipidomics and body fat composition analysis characterises specific differences in cholesterol metabolism and steatosis between hepatitis C virus genotypes 1 and 3 Open
Background Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy. It has been proposed that …
View article: Revisiting the Elusive Hepatitis C Vaccine
Revisiting the Elusive Hepatitis C Vaccine Open
The impactful discovery and subsequent characterisation of hepatitis C virus (HCV), an RNA virus of the flavivirus family, led to the awarding of the 2020 Nobel Prize in Physiology or Medicine to Harvey J [...]
View article: P88 The impact of NOD2 deficiency on the gut mycobiota in crohn’s disease patients in remission
P88 The impact of NOD2 deficiency on the gut mycobiota in crohn’s disease patients in remission Open
Introduction Crohn's disease (CD) is strongly associated with risk variants in Nod2 and an imbalanced gut microbiome. Historical and emerging data indicate that gut fungi play an important role in CD pathogenesis, however a causal link bet…
View article: The Impact of<i>NOD2</i>Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation
The Impact of<i>NOD2</i>Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation Open
Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to eva…
View article: COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (<scp>DPP4</scp>) in disease severity?
COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (<span>DPP4</span>) in disease severity? Open
The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar to SARS‐CoV and Middle East respiratory syndrome (MERS‐CoV), which cause acute res…
View article: Relapse of polymyalgia rheumatica following adjuvanted influenza vaccine: A case-based review
Relapse of polymyalgia rheumatica following adjuvanted influenza vaccine: A case-based review Open
Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatological condition affecting individuals aged >50 years. There have been rare reports of PMR and other vasculitides developing within 3 months of influenza vaccination. In…
View article: Temperate Bacteriophages from Chronic Pseudomonas aeruginosa Lung Infections Show Disease-Specific Changes in Host Range and Modulate Antimicrobial Susceptibility
Temperate Bacteriophages from Chronic Pseudomonas aeruginosa Lung Infections Show Disease-Specific Changes in Host Range and Modulate Antimicrobial Susceptibility Open
Pseudomonas aeruginosa is a key opportunistic respiratory pathogen in patients with cystic fibrosis and non-cystic fibrosis bronchiectasis. The genomes of these pathogens are enriched with mobile genetic elements including diverse temperat…
View article: Autoantibody to apolipoprotein A-1 in hepatitis C virus infection: a role in atherosclerosis?
Autoantibody to apolipoprotein A-1 in hepatitis C virus infection: a role in atherosclerosis? Open
Background/purpose One to three per cent of the world's population has hepatitis C virus (HCV) infection, which is not only a major cause of liver disease and cancer but also associated with an increased risk of atherosclerosis, despite an…
View article: Autoantibody to apolipoprotein A-1 in hepatitis C virus infection: a role in atherosclerosis?
Autoantibody to apolipoprotein A-1 in hepatitis C virus infection: a role in atherosclerosis? Open
This is the first report of the presence of an emerging biomarker for atherosclerosis, anti-apoA-1 IgG, in some patients with HCV infection. It may be induced by apoA-1 on the surface of HCV lipoviral particles. The autoantibodies inversel…
View article: Issue Information
Issue Information Open
Photograph of one of the giant Qinling pandas studied.Heavy metals and persistent organic pollutants present at high concentrations in polluted air are deposited on soils and accumulate in bamboo fed to the pandas bred in captivity at the …
View article: Shigatoxin encoding Bacteriophage ϕ24B modulates bacterial metabolism to raise antimicrobial tolerance
Shigatoxin encoding Bacteriophage ϕ24B modulates bacterial metabolism to raise antimicrobial tolerance Open
How temperate bacteriophages play a role in microbial infection and disease progression is not fully understood. They do this in part by carrying genes that promote positive evolutionary selection for the lysogen. Using Biolog phenotype mi…