Simon Haroutounian
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View article: Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits
Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits Open
Chronic pain (CP) is a debilitating condition that impacts an individual’s physical and mental health. CP is common, affecting around 12-40% of individuals across the world. In this study, we conducted a genome-wide association study (GWAS…
View article: IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain after Surgery v1
IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain after Surgery v1 Open
Chronic postsurgical pain (CPSP) is a major healthcare burden, affecting nearly 20% of patients undergoing major surgery. CPSP is associated with diminished quality of life, mood disturbances, functional impairment, and increases the risk …
View article: Predicting acute postsurgical pain in the postanesthesia care unit: risk tool development and internal validation
Predicting acute postsurgical pain in the postanesthesia care unit: risk tool development and internal validation Open
Introduction: Moderate-to-severe acute postsurgical pain (APSP) is experienced by approximately 30% of surgical patients. Objectives: To improve early APSP management, we developed 2 pragmatic and generalizable point-of-care risk tools to …
View article: Cortical spectral dynamics of vibrotactile frequency processing
Cortical spectral dynamics of vibrotactile frequency processing Open
View article: Remote Perioperative Symptom Monitoring via Smartphone: A largescale feasibility analysis
Remote Perioperative Symptom Monitoring via Smartphone: A largescale feasibility analysis Open
Ecological Momentary Assessment (EMA) may be useful in the surgical setting for predicting and monitoring symptoms including perioperative pain. However, no largescale studies have established the feasibility of perioperative EMA. The Pers…
View article: Androgen levels and experimental pain sensitivity in healthy young adolescent girls
Androgen levels and experimental pain sensitivity in healthy young adolescent girls Open
Androgens, such as testosterone, have an antinociceptive effect based on animal and adult studies. However, because androgens may exert different physiological effects during puberty, it is not clear whether the antinociceptive effect woul…
View article: Incorporating Uncertainty in Predictive Models Using Mobile Sensing and Clinical Data: A Case Study on Persistent Post-surgical Pain
Incorporating Uncertainty in Predictive Models Using Mobile Sensing and Clinical Data: A Case Study on Persistent Post-surgical Pain Open
Persistent postoperative pain (PPSP) is a significant concern in perioperative care, affecting patient quality of life and clinical outcomes. While traditional clinical data may capture patient-reported and objective physiological data in …
View article: The role of puberty in experimental pain sensitivity in healthy adolescent girls
The role of puberty in experimental pain sensitivity in healthy adolescent girls Open
Introduction: Puberty is a critical developmental period during which changes in pain sensitivity are observed. Previous studies found that older and more mature adolescents have lower experimental pain sensitivity. However, it is unclear …
View article: Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis
Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis Open
View article: Comparing Analgesic Regimen Effectiveness and Safety after Surgery (CARES): protocol for a pragmatic, international multicentre randomised trial
Comparing Analgesic Regimen Effectiveness and Safety after Surgery (CARES): protocol for a pragmatic, international multicentre randomised trial Open
Introduction Acute pain is commonly experienced by millions of patients who undergo outpatient surgical procedures. Moreover, an increasing number of procedures are performed on an outpatient basis, requiring greater postoperative planning…
View article: Cortical Spectral Dynamics of Vibrotactile Frequency Processing
Cortical Spectral Dynamics of Vibrotactile Frequency Processing Open
While scientific research has extensively explored how the brain integrates touch and pain signals, the cerebral processing of specific vibrotactile frequencies remains poorly understood. This gap is particularly significant given clinical…
View article: Bioanalytical considerations for quantification of ondansetron in rat microdialysis study using LC-MS/MS
Bioanalytical considerations for quantification of ondansetron in rat microdialysis study using LC-MS/MS Open
View article: Utilizing Semantic Textual Similarity for Clinical Survey Data Feature Selection
Utilizing Semantic Textual Similarity for Clinical Survey Data Feature Selection Open
View article: Experimental Pain Sensitivity and Parental Pain Catastrophizing
Experimental Pain Sensitivity and Parental Pain Catastrophizing Open
Background/Objectives: Variability in biopsychosocial factors can explain the interindividual variability in pain. One factor that can impact pain is the pain catastrophizing level. Interestingly, parental pain catastrophizing is related t…
View article: Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover‐design trial
Epidural methadone and morphine pharmacokinetics and clinical effects in healthy volunteers: A randomized, crossover‐design trial Open
Aims Epidural opioids can provide effective analgesia for acute postoperative pain. Due to its unique physicochemical properties and long systemic elimination half‐life, epidural methadone may provide lasting analgesia with minimal adverse…
View article: Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System
Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System Open
Purpose Serotonin (5-HT 3 ) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the central nervous system (CNS) might result in lack of efficacy. The goal of this study was t…
View article: Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled trials
Perioperative mental health intervention for depression and anxiety symptoms in older adults study protocol: design and methods for three linked randomised controlled trials Open
Introduction Preoperative anxiety and depression symptoms among older surgical patients are associated with poor postoperative outcomes, yet evidence-based interventions for anxiety and depression have not been applied within this setting.…
View article: Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort?
Cannabis oil extracts for chronic pain: what else can be learned from another structured prospective cohort? Open
Introduction: The use of medicinal cannabis for managing pain expands, although its efficacy and safety have not been fully established through randomized controlled trials. Objectives: This structured, prospective questionnaire-based coho…
View article: Non‐invasive non‐pharmacological therapies for chronic pain: A commentary on Ikarashi et al.
Non‐invasive non‐pharmacological therapies for chronic pain: A commentary on Ikarashi et al. Open
This journal recently published a paper by Ikarashi et al. entitled 'Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude' (Ikarashi e…
View article: Cognitive flexibility training for chronic pain: a randomized clinical study
Cognitive flexibility training for chronic pain: a randomized clinical study Open
Introduction: Previous studies suggest an association between cognitive flexibility and development of chronic pain after surgery. It is not known whether cognitive flexibility can be improved in patients with chronic pain. Objectives: Thi…
View article: A novel theta-controlled vibrotactile brain–computer interface to treat chronic pain: a pilot study
A novel theta-controlled vibrotactile brain–computer interface to treat chronic pain: a pilot study Open
Limitations in chronic pain therapies necessitate novel interventions that are effective, accessible, and safe. Brain–computer interfaces (BCIs) provide a promising modality for targeting neuropathology underlying chronic pain by convertin…
View article: Table of Contents
Table of Contents Open
View article: Peri‐operative mental health and pain after surgery: cause, consequence or coincidence?
Peri‐operative mental health and pain after surgery: cause, consequence or coincidence? Open
View article: Comparison of Joint Mobilization and Movement Pattern Training for Hip-Related Groin Pain: Ancillary Analysis to Assess 12-Month Outcomes of a Pilot Randomized Clinical Trial
Comparison of Joint Mobilization and Movement Pattern Training for Hip-Related Groin Pain: Ancillary Analysis to Assess 12-Month Outcomes of a Pilot Randomized Clinical Trial Open
OBJECTIVE: We compared 2 interventions for chronic hip-related groin pain (HRGP), joint mobilization (JtMob), and movement pattern training (MoveTrain), to determine if treatment effects observed immediately after treatment were sustained …
View article: Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations Open
In the traditional clinical research model, patients are typically involved only as participants. However, there has been a shift in recent years highlighting the value and contributions that patients bring as members of the research team,…
View article: Personal factors and baseline function in patients undergoing non-operative management for chronic hip-related groin pain: a cross-sectional study
Personal factors and baseline function in patients undergoing non-operative management for chronic hip-related groin pain: a cross-sectional study Open
Aim Little is known about the relationship between personal factors and perception of hip-related function among patients with chronic hip-related groin pain (HRGP) seeking non-operative management. This analysis was performed to determine…
View article: A Perioperative Mental Health Intervention for Depressed and Anxious Older Surgical Patients: Results From a Feasibility Study
A Perioperative Mental Health Intervention for Depressed and Anxious Older Surgical Patients: Results From a Feasibility Study Open
View article: Exploring the mitigation potential of tree crops ecosystems in the Mediterranean region
Exploring the mitigation potential of tree crops ecosystems in the Mediterranean region Open
Orchards agro-ecosystems display a significant potential to act a net sink for atmospheric carbon, offering significant land-based mitigation services. This mitigation potential depends greatly on cultivated species and applied cultivation…
View article: Comparison of Joint Mobilization and Movement Pattern Training for Patients With Hip-Related Groin Pain: A Pilot Randomized Clinical Trial
Comparison of Joint Mobilization and Movement Pattern Training for Patients With Hip-Related Groin Pain: A Pilot Randomized Clinical Trial Open
Objective The objective of this study was to assess the feasibility of completing a randomized clinical trial (RCT) and examine the preliminary effects of 2 interventions for hip-related groin pain (HRGP). Methods In this pilot RCT, patien…
View article: Utilizing Semantic Textual Similarity for Clinical Survey Data Feature Selection
Utilizing Semantic Textual Similarity for Clinical Survey Data Feature Selection Open
Survey data can contain a high number of features while having a comparatively low quantity of examples. Machine learning models that attempt to predict outcomes from survey data under these conditions can overfit and result in poor genera…