Simon Höllerer
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View article: Data-driven protease engineering by DNA-recording and epistasis-aware machine learning
Data-driven protease engineering by DNA-recording and epistasis-aware machine learning Open
Protein engineering has recently seen tremendous transformation due to machine learning (ML) tools that predict structure from sequence at unprecedented precision. Predicting catalytic activity, however, remains challenging, restricting ou…
View article: Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript Open
## Overview This repository contains the data and R-scripts to reproduce the figures in the main text of the manuscript "Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet…
View article: Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript Open
## Overview This repository contains the data and R-scripts to reproduce the figures in the main text of the manuscript "Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet…
View article: Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript Open
Translation is a key determinant of gene expression and an important biotechnological engineering target. In bacteria, 5′-untranslated region (5′-UTR) and coding sequence (CDS) are well-known mRNA parts controlling translation and thus cel…
View article: Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript
Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript Open
Translation is a key determinant of gene expression and an important biotechnological engineering target. In bacteria, 5’-untranslated region (5’-UTR) and coding sequence (CDS) are well-known mRNA parts controlling translation and thus cel…
View article: Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping
Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping Open
Data underlying the figures in the publication “Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping”, published in Nat Commun, 2020, 11, 3551. https://doi.org/10.1038/s41467-020-172…
View article: Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping
Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping Open
Data underlying the figures in the publication “Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping”, published in Nat Commun, 2020, 11, 3551. https://doi.org/10.1038/s41467-020-172…
View article: Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping
Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping Open
Predicting quantitative effects of gene regulatory elements (GREs) on gene expression is a longstanding challenge in biology. Machine learning models for gene expression prediction may be able to address this challenge, but they require ex…
View article: Addendum: A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
Addendum: A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications Open
increase in BMI, where (i) BMI is standardized to a standard normal distribution (1 unit equivalent to one standard deviation of BMI, ~4.5 kg/m 2 ), and (ii) this increase in BMI refers to the specific adiposity subtype (given by the respe…