Sandrine Hughes
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View article: Characterizing drug activity with sensitive interactomes in human living cells
Characterizing drug activity with sensitive interactomes in human living cells Open
A number of human diseases results from abnormal protein-protein interactions (PPIs) involving key regulatory proteins. Therefore, an important strategy in therapeutics consists in developing inhibitory molecules that should ideally be spe…
View article: Single-cell transcriptomic profiling of zebrafish primary motor neurons reveals subtype-specific gene expression signatures
Single-cell transcriptomic profiling of zebrafish primary motor neurons reveals subtype-specific gene expression signatures Open
View article: <i>Candida albicans</i> releases a peptide from the Rbt1 protein to promote its invasion into the gut epithelium
<i>Candida albicans</i> releases a peptide from the Rbt1 protein to promote its invasion into the gut epithelium Open
Candida albicans has been recently added to the WHO critical priority group of fungal pathogens based on its impact on global public health. C. albicans is a mucosal commensal yeast in humans that can cause severe gastrointes…
View article: Spatio-temporal control of myoblast identity drives muscle diversity in the Drosophila leg
Spatio-temporal control of myoblast identity drives muscle diversity in the Drosophila leg Open
SUMMARY Skeletal muscles display remarkable morphological diversity, but the developmental mechanisms specifying distinct muscle morphology remain poorly understood. Using Drosophila leg muscles as a model, we uncover how naïve mesodermal …
View article: Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil
Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil Open
Background Insects thriving on a nutritionally imbalanced diet often establish long-term relationships with intracellular symbiotic bacteria (endosymbionts), which complement their nutritional needs and improve their physiological performa…
View article: Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition
Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition Open
Dietary protein sufficiency during childhood is essential for healthy growth and tissue development. Chronic protein deficiency leads to stunting, height-for-age more than two standard deviations below the median, and affects 149 million c…
View article: An Atlas of Thyroid Hormone Responsive Genes in Adult Mouse Hypothalamus
An Atlas of Thyroid Hormone Responsive Genes in Adult Mouse Hypothalamus Open
We present an atlas of genes that respond to thyroid hormone in the adult mouse mediobasal hypothalamus. Based on droplet-based single nuclei RNA-seq method and batch transcriptome analyses, the atlas lists putative target genes of the hor…
View article: Lactiplantibacillus plantarum strains with enhanced animal growth promoting capabilities in well fed animals
Lactiplantibacillus plantarum strains with enhanced animal growth promoting capabilities in well fed animals Open
The gut microbiota has a profound impact on animal physiology, improving organ function and promoting growth under different nutritional conditions. Complex mechanisms underlying growth-promotion by the gut microbiota have been described. …
View article: Bounds on Coloring Trees without Rainbow Paths
Bounds on Coloring Trees without Rainbow Paths Open
For a graph with colored vertices, a rainbow subgraph is one where all vertices have different colors. For graph $G$, let $c_k(G)$ denote the maximum number of different colors in a coloring without a rainbow path on $k$ vertices, and $cp_…
View article: Bounds on coloring trees without rainbow paths
Bounds on coloring trees without rainbow paths Open
View article: Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues
Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues Open
Transposable elements (TEs) are repeated DNA sequences potentially able to move throughout the genome. In addition to their inherent mutagenic effects, TEs can disrupt nearby genes by donating their intrinsic regulatory sequences, for inst…
View article: Targeting a shared neoepitope derived from non-canonical translation of c-<i>MYC</i>oncogene in cancer cells
Targeting a shared neoepitope derived from non-canonical translation of c-<i>MYC</i>oncogene in cancer cells Open
Cancer cells rely on alternative modes of translation for protein synthesis, promoting internal ribosome entry site (IRES)-dependent translation of mRNA encoding pro-oncogenic factors. Furthermore, ribosomes translate mRNA with lower fidel…
View article: AtVPS13M1 is involved in lipid remodeling in low phosphate and is located at the mitochondria surface in plants
AtVPS13M1 is involved in lipid remodeling in low phosphate and is located at the mitochondria surface in plants Open
VPS13 are conserved lipid transporters with multiple subcellular localizations playing key roles in many fundamental cellular processes. While the localization and function of VPS13 have been extensively investigated in yeast and animals, …
View article: Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons
Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons Open
During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose identities and cellular source remain poorly characterized. Here, using single-cell RNAseq of sor…
View article: Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.
Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp. Open
View article: Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes
Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes Open
The disturbance of intercellular communication is one of the hallmarks of aging. The goal of this study is to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues. We f…
View article: Optimization for High-Throughput BiFC Screening
Optimization for High-Throughput BiFC Screening Open
The Cell-PCA screen, since its inception, has provided an efficient method for analyzing cellular interactomes and has been used in various biological studies involving proteins like MYC, PER2, and ERK. With rapid advancements in biotechno…
View article: Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons
Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons Open
Symbiotic bacteria interact with their host through symbiotic cues. Here, we took advantage of the mutualism between Drosophila and Lactiplantibacillus plantarum (Lp) to investigate a novel mechanism of host-symbiont interaction. Using che…
View article: Identification and quantification of transposable element transcripts using Long-Read RNA-seq in <i>Drosophila</i> germline tissues
Identification and quantification of transposable element transcripts using Long-Read RNA-seq in <i>Drosophila</i> germline tissues Open
Transposable elements (TEs) are repeated DNA sequences potentially able to move throughout the genome. In addition to their inherent mutagenic effects, TEs can disrupt nearby genes by donating their intrinsic regulatory sequences, for inst…
View article: Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons
Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons Open
During development, motor axons are guided towards their muscle target by various extrinsic cues including extracellular matrix (ECM) proteins those identities remain poorly documented. Using single-cell RNA-sequencing of differentiating s…
View article: Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil<i>Sitophilus</i>spp
Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil<i>Sitophilus</i>spp Open
Background Insects living in nutritionally poor environments often establish long-term relationships with intracellular bacteria that supplement their diets and improve their adaptive and invasive powers. Even though these symbiotic associ…
View article: Preclinical Pharmacology of Solriamfetol: Potential Mechanisms for Wake Promotion
Preclinical Pharmacology of Solriamfetol: Potential Mechanisms for Wake Promotion Open
Introduction Solriamfetol is a wake-promoting agent (WPA) approved for the treatment of excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea. The wake-promoting mechanism of solriamfetol may result from dopam…
View article: New insights from short and long reads sequencing to explore cytochrome b variants in Plasmopara viticola populations collected from vineyards and related to resistance to complex III inhibitors
New insights from short and long reads sequencing to explore cytochrome b variants in Plasmopara viticola populations collected from vineyards and related to resistance to complex III inhibitors Open
Downy mildew is caused by Plasmopara viticola , an obligate oomycete plant pathogen, a devasting disease of grapevine. To protect plants from the disease, complex III inhibitors are among the fungicides widely used. They specifically targe…
View article: Author response: Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons
Author response: Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons Open
View article: A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes
A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes Open
Biological pathways rely on the formation of intricate protein interaction networks called interactomes. Getting a comprehensive map of interactomes implies the development of tools that allow one to capture transient and low-affinity prot…
View article: A live cell protein complementation assay for ORFeome-wide probing of human HOX interactomes
A live cell protein complementation assay for ORFeome-wide probing of human HOX interactomes Open
Biological pathways rely on the formation of intricate protein interaction networks called interactomes. Getting a comprehensive map of interactomes implies developing tools that allow capturing transient and low affinity protein-protein i…
View article: Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes
Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes Open
The disturbance of intercellular communication is one of the hallmarks of aging. The goal of this study is to clarify the impact of chronological aging on extracellular vesicles (EVs), a key mode of communication in mammalian tissues. We f…
View article: Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system
Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system Open
View article: NRF2 Shortage in Human Skin Fibroblasts Dysregulates Matrisome Gene Expression and Affects Collagen Fibrillogenesis
NRF2 Shortage in Human Skin Fibroblasts Dysregulates Matrisome Gene Expression and Affects Collagen Fibrillogenesis Open
View article: Distinct gene expression dynamics in developing and regenerating crustacean limbs
Distinct gene expression dynamics in developing and regenerating crustacean limbs Open
Regenerating animals have the ability to reproduce body parts that were originally made in the embryo and subsequently lost due to injury. Understanding whether regeneration mirrors development is an open question in most regenerative spec…