Simon Imakwu Okekpa
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View article: Assessment of haematological indices and age-related risk factors among malaria parasitized pregnant women attending antenatal clinics in Benin City
Assessment of haematological indices and age-related risk factors among malaria parasitized pregnant women attending antenatal clinics in Benin City Open
Malaria remains a significant global health challenge, particularly affecting vulnerable populations such as pregnant women in endemic regions, contributing substantially to maternal morbidity and mortality despite concerted efforts to con…
View article: Prevalence of Nasopharyngeal carcinoma among patients in Ebonyi State, Nigeria
Prevalence of Nasopharyngeal carcinoma among patients in Ebonyi State, Nigeria Open
Nasopharyngeal carcinoma is a malignant tumor of the nasopharynx with skewed geographical distribution. The aim of the study was to determine the prevalence of NPC and ascertain the predominant age and NPC type in Ebonyi state Nigeria. Pat…
View article: Awareness and Practices of Breast Cancer Detection among Female Undergraduates of Ebonyi State University, Nigeria
Awareness and Practices of Breast Cancer Detection among Female Undergraduates of Ebonyi State University, Nigeria Open
Background: Breast cancer is a global health issue affecting women with, early detection through breast-self-examination and Clinical-Breast Examination being crucial for increasing the rate of survival. Aim: This study aimed to ascertain …
View article: Understanding Stim-1 Regulatory Networks in Nasopharyngeal Cancer Using Functional, Transcriptomics, Proteomics, and in-silico Approaches
Understanding Stim-1 Regulatory Networks in Nasopharyngeal Cancer Using Functional, Transcriptomics, Proteomics, and in-silico Approaches Open
Objective Stromal-interaction molecule 1 (STIM-1) aberrant expression contributes significantly to cancer pathogenesis. The present work studied STIM-1 regulatory networks in nasopharyngeal cancer (NPC) models via functional, transcriptome…
View article: PRELIMINARY ANALYSIS OF STIM-1 EXPRESSION ON FORMALIN-FIXED PARAFFIN-EMBEDDED NASOPHARYNGEAL CANCER TISSUES
PRELIMINARY ANALYSIS OF STIM-1 EXPRESSION ON FORMALIN-FIXED PARAFFIN-EMBEDDED NASOPHARYNGEAL CANCER TISSUES Open
Nasopharyngeal cancer (NPC) is commonly diagnosed at the advanced stage with a poor prognosis. STIM-1 has become a promising cancer biomarker, especially in early diagnostic applications. There is a limited study on STIM1 expression in NPC…
View article: Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloblastic Leukemia-M5 Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities
Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloblastic Leukemia-M5 Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities Open
This study has demonstrated the role of STIM1 in promoting AML cell proliferation and survival through enhanced ROS generation and regulation of AKT/MAPK-related pathways. These findings may help establish STIM1 as a potentia…
View article: Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloid Leukemia Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities
Knockdown of Stromal Interaction Molecule 1 (STIM1) Suppresses Acute Myeloid Leukemia Cell Line Survival Through Inhibition of Reactive Oxygen Species Activities Open
Stromal interaction molecule 1 ( STIM1 ) is a critical regulator of calcium homeostasis through store-operated calcium entry (SOCE) and recently considered a potential therapeutic target for cancer. However, the role of STIM1 in acute myel…
View article: Racial Disparities Associated with the Prevalence of Vaccine and Non-Vaccine HPV Types and Multiple HPV Infections between Asia and Africa: A Systematic Review and Meta-Analysis
Racial Disparities Associated with the Prevalence of Vaccine and Non-Vaccine HPV Types and Multiple HPV Infections between Asia and Africa: A Systematic Review and Meta-Analysis Open
This study suggests that the higher prevalence of HPV, multiple HPV and non-vaccine HPV infections could be responsible for the higher ASIR in Africa than in Asia.
View article: Clinical diagnosis of prostate cancer using digital rectal examination and prostate-specific antigen tests: a systematic review and meta-analysis of sensitivity and specificity
Clinical diagnosis of prostate cancer using digital rectal examination and prostate-specific antigen tests: a systematic review and meta-analysis of sensitivity and specificity Open
Background Being diagnosed with cancer, irrespective of type initiates a serious psychological concern. The increasing rate of detection of indolent prostate cancers is a source of worry to public health. Digital rectal examination and pro…
View article: Racial disparities in the prevalence of vaccine and non-vaccine HPV types and multiple HPV infection between Asia and Africa: A systematic review
Racial disparities in the prevalence of vaccine and non-vaccine HPV types and multiple HPV infection between Asia and Africa: A systematic review Open
Summary Background Cervical Cancer is the 6 th most common and 3 rd most deadly cancer among women. Despite the fact that majority of the countries in Asia and Africa have similar economy and low life expectancy, the mean age standardized …
View article: The Association between Tea Consumption and Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis
The Association between Tea Consumption and Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis Open
Heated debates have been on-going about tea consumption and the incidence of cancer, especially in head and neck cancer types. This study aimed to review the association between tea consumption habits and nasopharyngeal cancer (NPC). Metho…
View article: Nasopharyngeal Carcinoma (NPC) Risk Factors: A Systematic Review and Meta-Analysis of the Association with Lifestyle, Diets, Socioeconomic and Sociodemographic in Asian Region
Nasopharyngeal Carcinoma (NPC) Risk Factors: A Systematic Review and Meta-Analysis of the Association with Lifestyle, Diets, Socioeconomic and Sociodemographic in Asian Region Open
This study proposes that salted fish intake, smoking and alcohol consumption might be linked to NPC risk in Asians. Further studies are necessary to ascertain the molecular mechanisms and clarify if the associated path that could function …
View article: Reactive Oxygen Species, Cellular Redox Homeostasis and Cancer
Reactive Oxygen Species, Cellular Redox Homeostasis and Cancer Open
Redox homeostasis is attained by the cautious regulation of both reactive oxygen species (ROS) formation and removal from the body system. A shift in ROS balance promotes oxidative injury and tumour development by inflicting damage to DNA …
View article: Transcriptional gene expression profiles on nasopharyngeal carcinoma/HK1 cell line with siRac1-mediated knockdown
Transcriptional gene expression profiles on nasopharyngeal carcinoma/HK1 cell line with siRac1-mediated knockdown Open
Event Abstract Back to Event Transcriptional gene expression profiles on nasopharyngeal carcinoma/HK1 cell line with siRac1-mediated knockdown Rabiatul Basria S. M. N. Mydin1*, Simon I. Okekpa1, 2, Emmanuel J. Moses3, Adam Azlan3, Gurjeet …
View article: A Novel Methicillin-Resistant<i>Staphylococcus aureus</i>t11469 and a Poultry Endemic Strain t002 (ST5) Are Present in Chicken in Ebonyi State, Nigeria
A Novel Methicillin-Resistant<i>Staphylococcus aureus</i>t11469 and a Poultry Endemic Strain t002 (ST5) Are Present in Chicken in Ebonyi State, Nigeria Open
Background . The changing epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) from a hospital-associated pathogen to an organism commonly found in the community and in livestock reflects an organism well-equipped to survive …