Simon K. Jackson
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View article: Water Quality Assessment: Endotoxin Brings Real-Time Measurements and Non-Faecally Transmitted Bacteria to the Table
Water Quality Assessment: Endotoxin Brings Real-Time Measurements and Non-Faecally Transmitted Bacteria to the Table Open
We have used a rapid, portable assay (Bacterisk) to determine the bacterial water quality along several inland waters in SW England. Water samples were compared by a conventional membrane filter and culture methods for faecal indicator bac…
View article: Water Quality Assessment: Endotoxin Brings Real-Time Measurements and Non-Faecally Transmitted Bacteria to the Table
Water Quality Assessment: Endotoxin Brings Real-Time Measurements and Non-Faecally Transmitted Bacteria to the Table Open
We have used a rapid, portable assay (Bacterisk) to determine bacterial water quality along several inland waters in SW England. Water samples were compared by conventional membrane filter and culture methods for faecal indicator bacteria …
View article: Air quality and mental illness: role of bioaerosols, causal mechanisms and research priorities
Air quality and mental illness: role of bioaerosols, causal mechanisms and research priorities Open
Background Poor air quality can both trigger and aggravate lung and heart conditions, as well as affecting child development. It can even lead to neurological and mental health problems. However, the precise mechanisms by which air polluti…
View article: Endotoxin, a novel biomarker for the rapid risk assessment of faecal contamination of coastal and transitional waters
Endotoxin, a novel biomarker for the rapid risk assessment of faecal contamination of coastal and transitional waters Open
Current methods for testing water for faecal contamination rely on the culture of faecal indicator bacteria (FIB; Escherichia coli and Enterococci) that take 24–48 h, which leads to delays in taking proactive measures and poses a risk to p…
View article: Lysophosphatidylcholine Acetyltransferase 2 (LPCAT2) Influences the Gene Expression of the Lipopolysaccharide Receptor Complex in Infected RAW264.7 Macrophages, Depending on the E. coli Lipopolysaccharide Serotype
Lysophosphatidylcholine Acetyltransferase 2 (LPCAT2) Influences the Gene Expression of the Lipopolysaccharide Receptor Complex in Infected RAW264.7 Macrophages, Depending on the E. coli Lipopolysaccharide Serotype Open
Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 …
View article: Air quality and mental health: evidence, challenges and future directions
Air quality and mental health: evidence, challenges and future directions Open
Background Poor air quality is associated with poor health. Little attention is given to the complex array of environmental exposures and air pollutants that affect mental health during the life course. Aims We gather interdisciplinary exp…
View article: LPCAT2 Regulates CD14 Expression During Macrophage Inflammatory Response to E. coli O111:B4
LPCAT2 Regulates CD14 Expression During Macrophage Inflammatory Response to E. coli O111:B4 Open
LPCAT2 is a lipid-modifying enzyme that co-localises in lipid rafts with TLR4 and regulates macrophage inflammatory response; however, its effect on TLR4 co-receptor–CD14 is unknown. RAW264.7 cells, a common murine macrophage experimental …
View article: Endotoxin as a Marker for Water Quality
Endotoxin as a Marker for Water Quality Open
Background: Water quality testing is vital to protect human health. Current testing relies mainly on culture-based detection of faecal indicator organisms such as Escherichia coli (E.coli). However, bacterial cultures are a slow process, t…
View article: Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia Open
Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is no…
View article: Signatures of increasing environmental stress in bumblebee wings over the past century: Insights from museum specimens
Signatures of increasing environmental stress in bumblebee wings over the past century: Insights from museum specimens Open
Determining when animal populations have experienced stress in the past is fundamental to understanding how risk factors drive contemporary and future species' responses to environmental change. For insects, quantifying stress and associat…
View article: First large‐scale quantification study of DNA preservation in insects from natural history collections using genome‐wide sequencing
First large‐scale quantification study of DNA preservation in insects from natural history collections using genome‐wide sequencing Open
Insect declines are a global issue with significant ecological and economic ramifications. Yet, we have a poor understanding of the genomic impact these losses can have. Genome‐wide data from historical specimens have the potential to prov…
View article: 1330 Assessing the impact of investigation checklists in paediatric intensive care unit
1330 Assessing the impact of investigation checklists in paediatric intensive care unit Open
Aims Checklists are a valued cognitive aid, used in multiple specialities, and are effective tools for decreasing morbidity, mortality and improving efficiency in emergency and non-emergency situations.1,2 Within a United Kingdom Paediatri…
View article: 1314 Availability of video laryngoscopes within 2 tertiary United Kingdom paediatric hospitals
1314 Availability of video laryngoscopes within 2 tertiary United Kingdom paediatric hospitals Open
Aims As part of intra-hospital resuscitation teams, Paediatric Intensive Care (PIC) and Anaesthetic trainees may be expected to intubate children in locations outside their familiar environment of Paediatric Intensive Care Units or Theatre…
View article: Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells
Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells Open
Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although there is extensive research on…
View article: Lysophosphatidylcholine acyltransferase 2 (LPCAT2) Regulates The Expression of Macrophage Phenotype Markers in RAW264.7 Cells
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) Regulates The Expression of Macrophage Phenotype Markers in RAW264.7 Cells Open
1 Abstract Macrophages are key antigen presenting cells that also secrete cytokines during inflammation. They can be polarised to M1 or M2 phenotypes. Molecules such as CD206 and inducible Nitric Oxide Synthase are considered macrophage ph…
View article: Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells
Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells Open
1 Abstract Inflammation is central to several diseases. TLR4 mediates inflammatory signals, however, there are gaps in the understanding of its mechanisms. Recently, TLR4 was found to co-localise with LPCAT2, a lysophospholipid acetyltrans…
View article: Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs
Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs Open
Sepsis is a major worldwide healthcare issue with unmet clinical need. Despite extensive animal research in this area, successful clinical translation has been largely unsuccessful. We propose one reason for this is that, sometimes, the ex…
View article: Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS Open
Despite extensive investigations, an effective treatment for sepsis remains elusive and a better understanding of the inflammatory response to infection is required to identify potential new targets for therapy. In this study we have used …
View article: Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing
Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing Open
Oropouche virus (OROV) is responsible for outbreaks of Oropouche fever in parts of South America. We recently identified and isolated OROV from a febrile Ecuadorian patient, however, a previously published qRT-PCR assay did not detect OROV…
View article: Oropouche virus cases identified in Ecuador using an optimised rRT-PCR informed by metagenomic sequencing
Oropouche virus cases identified in Ecuador using an optimised rRT-PCR informed by metagenomic sequencing Open
Oropouche virus (OROV) is responsible for outbreaks of Oropouche fever in parts of South America. We recently identified and isolated OROV from a febrile Ecuadorian patient, however, a previously published rRT-PCR assay did not detect OROV…
View article: Understanding the pathogenic process of uropathogenic Escherichia coli ST127 using proteomics on uroepithelial co-culture samples
Understanding the pathogenic process of uropathogenic Escherichia coli ST127 using proteomics on uroepithelial co-culture samples Open
Background Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infection (UTI). Strains of sequence type (ST) 127 exhibit the highest virulence potential of most UPEC strains, but little is known about pathogeni…
View article: Subgingival lipid A profile and endotoxin activity in periodontal health and disease
Subgingival lipid A profile and endotoxin activity in periodontal health and disease Open
Subgingival endotoxin activity (determined by lipid A chemical composition) could be a reliable, bacterially derived biomarker and a risk assessment tool for personalized periodontal care.
View article: A Controlled Study on the Characterisation of Bioaerosols Emissions from Compost
A Controlled Study on the Characterisation of Bioaerosols Emissions from Compost Open
Bioaerosol emissions arising from biowaste treatment are an issue of public concern. To better characterise the bioaerosols, and to assess a range of measurement methods, we aerosolised green waste compost under controlled conditions. Viab…
View article: Sources of Airborne Endotoxins in Ambient Air and Exposure of Nearby Communities—A Review
Sources of Airborne Endotoxins in Ambient Air and Exposure of Nearby Communities—A Review Open
Endotoxin is a bioaerosol component that is known to cause respiratory effects in exposed populations. To date, most research focused on occupational exposure, whilst much less is known about the impact of emissions from industrial operati…
View article: Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model
Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model Open
Compared to two-dimensional (2D) cell culture, cellular aggregates or spheroids (3D) offer a more appropriate alternative in vitro system where individual cell-cell communication and micro-environment more closely represent the in vivo org…
View article: TOWARDS IMPROVED BIOAEROSOL MODEL VALIDATION AND VERIFICATION
TOWARDS IMPROVED BIOAEROSOL MODEL VALIDATION AND VERIFICATION Open
Bioaerosols, comprised of bacteria, fungi and viruses are ubiquitous in ambient air. Known to adversely affect human health, the impact of bioaerosols on a population often manifests as outbreaks of illnesses such as Legionnaires Disease a…
View article: Isolation of Oropouche Virus from Febrile Patient, Ecuador
Isolation of Oropouche Virus from Febrile Patient, Ecuador Open
We report identification of an Oropouche virus strain in a febrile patient from Ecuador by using metagenomic sequencing and real-time reverse transcription PCR. Virus was isolated from patient serum by using Vero cells. Phylogenetic analys…
View article: Correction to “Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via <i>in Situ</i> Grafting of Aryl Diazonium”
Correction to “Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via <i>in Situ</i> Grafting of Aryl Diazonium” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via in Situ Grafting of Aryl Diazonium"…