Simon Körver
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View article: Progressive Changes in Cerebral Apparent Diffusion Values in Fabry Disease: A 5-Year Follow-up MRI Study
Progressive Changes in Cerebral Apparent Diffusion Values in Fabry Disease: A 5-Year Follow-up MRI Study Open
Our results indicate that in Fabry disease, changes in diffusion precede the formation of white matter lesions and that microstructural changes progress faster in men compared with women. These findings suggest that DWI may be of predictiv…
View article: Cognitive functioning and depressive symptoms in Fabry disease: A follow‐up study
Cognitive functioning and depressive symptoms in Fabry disease: A follow‐up study Open
Patients with Fabry disease (FD) have a high prevalence of depressive symptoms and can suffer from cognitive impairment, negatively affecting their life. The course of cognitive functioning and depressive symptoms in FD is unknown. The aim…
View article: Determinants of cerebral radiological progression in Fabry disease
Determinants of cerebral radiological progression in Fabry disease Open
Background and aim It is unclear which patients with Fabry disease (FD) are at risk for progression of white matter lesions (WMLs) and brain infarctions and whether enzyme replacement therapy (ERT) changes this risk. The aim of this study …
View article: Depressive symptoms in Fabry disease: the importance of coping, subjective health perception and pain
Depressive symptoms in Fabry disease: the importance of coping, subjective health perception and pain Open
Background Despite the high prevalence of depressive symptoms in Fabry disease (FD), it is unclear which patient characteristics are important in relation to these symptoms. Additionally, the impact of coping styles in relation to depressi…
View article: Fabry and the brain: Incorporating patients’ illness perceptions into the physicians’ practice
Fabry and the brain: Incorporating patients’ illness perceptions into the physicians’ practice Open
Cerebral involvement is common in Fabry disease (FD). This thesis aimed to incorporate patients’ illness perception (e.g. depressive symptoms, quality of life) into the physicians’ practice (follow-up schedules and treatment). We aimed to …
View article: The Mini Mental State Examination does not accurately screen for objective cognitive impairment in Fabry Disease
The Mini Mental State Examination does not accurately screen for objective cognitive impairment in Fabry Disease Open
Fabry disease (FD) patients may suffer from objective cognitive impairment (OCI). This study assessed the accuracy of the Mini Mental State Examination (MMSE) to screen for OCI in FD patients. Presence or absence of OCI was established usi…
View article: A paraplegic patient with fever and leucocytosis: not always what it seems
A paraplegic patient with fever and leucocytosis: not always what it seems Open
A 54-year-old obese woman with a history of spina bifida was admitted to the hospital with malaise and fever accompanied by leucocytosis, thrombocytosis, and hypercalcaemia. As treatment for neurogenic bladder dysfunction she had a suprapu…
View article: Adaptive pathway development for Fabry disease: a clinical approach
Adaptive pathway development for Fabry disease: a clinical approach Open
Fabry disease (FD) is a rare X-chromosome-linked lysosomal storage disorder. Although initial expectations of enzyme replacement therapy (ERT) were high, it is now clear that real-world effectiveness is disappointing and evidence gathering…
View article: Phenotype, disease severity and pain are major determinants of quality of life in Fabry disease: results from a large multicenter cohort study
Phenotype, disease severity and pain are major determinants of quality of life in Fabry disease: results from a large multicenter cohort study Open
Quality of life (QoL) is decreased in patients with Fabry disease (FD). To improve QoL, it is important to understand the influence of FD related characteristics, symptoms, and complications. In this retrospective cohort study we explored …