Simon Lambden
YOU?
Author Swipe
View article: Representation Learning of Human Disease Mechanisms for a Foundation Model in Rare and Common Diseases
Representation Learning of Human Disease Mechanisms for a Foundation Model in Rare and Common Diseases Open
The limited amount of data available renders it challenging to characterize which biological processes are relevant to a rare disease. Hence, there is a need to leverage the knowledge of disease pathogenesis and treatment from the wider di…
View article: Identification of the biomarker soluble TREM-1 as a candidate for a personalised medicine approach for nangibotide treatment of septic shock
Identification of the biomarker soluble TREM-1 as a candidate for a personalised medicine approach for nangibotide treatment of septic shock Open
Background:One of main new avenue of exploration in critical care medicine is the development of personalized medicine approaches to better determine which therapy provides the optimal risk/benefit ratio for subgroups of septic shock patie…
View article: sTREM-1 is a specific biomarker of TREM-1 pathway activation
sTREM-1 is a specific biomarker of TREM-1 pathway activation Open
TREM-1 (triggering receptor expressed on myeloid cells-1) is a transmembrane receptor expressed by innate immune cells, including endothelial cells and platelets. TREM-1 is a crucial mediator of septic shock that acts by synergizing with T…
View article: Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19 Open
Patients with sepsis display increased concentrations of sTREM-1 (soluble Triggering Receptor Expressed on Myeloid cells 1), and a phase II clinical trial focusing on TREM-1 modulation is ongoing. We investigated whether sTREM-1 circulatin…
View article: Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial
Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial Open
Introduction Septic shock is the subgroup of patients with sepsis, which presents as vasopressor dependence, an elevated blood lactate concentration and is associated with a mortality of at least 30%. Expression of the triggering receptor …
View article: 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia Open
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in …
View article: 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia.
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia. Open
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in …
View article: Metabolite X is a novel biomarker for sepsis diagnosis and treatment
Metabolite X is a novel biomarker for sepsis diagnosis and treatment Open
Background: Sepsis develops when the initial, appropriate host response to an infection becomes amplified and subsequently dysregulated. Recent research has shown that the pathogenesis of sepsis can only partially be explained by an aberra…
View article: Rapid onset of severe septic shock in the pregnant mouse†
Rapid onset of severe septic shock in the pregnant mouse† Open
Sepsis-related mortality was markedly greater in pregnant mice. Cardiovascular collapse and organ dysfunction occurred sooner in pregnancy, but bacterial killing was similar. Circulating and tissue cytokine levels were similar, but immune …
View article: Monocyte dimethylarginine dimethylaminohydrolase 2 is regulated by pathological stress and plays a critical role in the immune response to sepsis
Monocyte dimethylarginine dimethylaminohydrolase 2 is regulated by pathological stress and plays a critical role in the immune response to sepsis Open
Background: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase (NOS) and regulates the synthesis of nitric oxide (NO) in vivo. ADMA is metabolised by the enzymes dimethylarginine dimethylamin…
View article: Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis
Dimethylarginine Dimethylaminohydrolase 2 Regulates Nitric Oxide Synthesis and Hemodynamics and Determines Outcome in Polymicrobial Sepsis Open
Objective— Nitric oxide is a key to numerous physiological and pathophysiological processes. Nitric oxide production is regulated endogenously by 2 methylarginines, asymmetric dimethylarginine (ADMA) and monomethyl- l -arginine. The enzyme…