Simon Lauer
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View article: An NADH-controlled gatekeeper of ATP synthase
An NADH-controlled gatekeeper of ATP synthase Open
ATP fuels crucial cellular processes and is obtained mostly by oxidative phosphorylation (OXPHOS) at the inner mitochondrial membrane. While significant progress has been made in mechanistic understanding of ATP production, critical aspect…
View article: An NADH-controlled gatekeeper of ATP synthase
An NADH-controlled gatekeeper of ATP synthase Open
ATP fuels crucial cellular processes and is obtained mostly by oxidative phosphorylation (OXPHOS) at the inner mitochondrial membrane. While significant progress has been made in mechanistic understanding of ATP production, critical aspect…
View article: Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88
Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88 Open
Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis by binding to the polypeptide exit tunnel (PET) near the peptidyl transferase center. Api137, an optimized derivative of honeybee PrAMP apidaecin, inhibits…
View article: Cryo-EM captures early ribosome assembly in action
Cryo-EM captures early ribosome assembly in action Open
Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of ribosomal RNAs (rRNAs) and ribosomal proteins. To obtain insights into the still…
View article: An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant
An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant Open
The SARS-CoV2 Omicron variant sub-lineages spread rapidly through the world, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and underscores the need for anti-SARS…
View article: Time-resolved cryo-EM reveals early ribosome assembly in action
Time-resolved cryo-EM reveals early ribosome assembly in action Open
Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of ribosomal RNAs (rRNAs) and ribosomal proteins. To obtain insights into the still…
View article: Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism Open
Human cytomegalovirus (CMV) is a highly relevant and ubiquitously distributed human pathogen. Its rodent counterparts such as mouse and rat CMV serve as common infection models. Here, we conducted the first global proteome profiling of rat…
View article: Visualization of Cortical Modules in Flattened Mammalian Cortices
Visualization of Cortical Modules in Flattened Mammalian Cortices Open
The cortex of mammalian brains is parcellated into distinct substructures or modules. Cortical modules typically lie parallel to the cortical sheet, and can be delineated by certain histochemical and immunohistochemical methods. In this st…
View article: Sexually selected size differences and conserved sexual monomorphism of genital cortex
Sexually selected size differences and conserved sexual monomorphism of genital cortex Open
The mammalian somatosensory cortex shows marked species‐specific differences. How evolution in general and sexual selection in particular shape the somatosensory cortical body representation has not been delineated, however. Here we addres…