Simon S. Y. Lui
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View article: Dysfunctions of Reward Motivation Adaptation in Patients With Schizophrenia
Dysfunctions of Reward Motivation Adaptation in Patients With Schizophrenia Open
Diminished reward motivation in the wanting or liking dimension constitutes one of the core dysfunctions in patients with schizophrenia (SCZ). However, it remains unclear whether patients with SCZ would dynamically adapt their wanting or l…
View article: Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting‐State <scp>fMRI</scp> Study Using Co‐Activation Pattern Analysis
Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting‐State <span>fMRI</span> Study Using Co‐Activation Pattern Analysis Open
Negative symptoms remain a major therapeutic challenge in schizophrenia, significantly impacting functional outcomes, yet their underlying neural mechanisms remain poorly understood. Traditional static functional connectivity analyses, whi…
View article: The effect of prenatal psychotropic drug exposures on obstetric complications: 19-year population-based study
The effect of prenatal psychotropic drug exposures on obstetric complications: 19-year population-based study Open
Background Although current prescribing guidelines suggest continuation of psychotropic drugs in pregnant women, population-based evidence supporting their safety is limited. Aims This study aims to clarify the plausible causal links betwe…
View article: Pharmacogenetic study of antipsychotic–induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study
Pharmacogenetic study of antipsychotic–induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study Open
Second-generation antipsychotics (SGAs) are widely used to treat schizophrenia (SCZ), but they often induce metabolic side effects like dyslipidemia and obesity. We conducted genome-wide association studies (GWASs) to identify genetic vari…
View article: Population-based study of long-term mortality risk associated with clozapine use among patients with schizophrenia
Population-based study of long-term mortality risk associated with clozapine use among patients with schizophrenia Open
Background Patients with schizophrenia have a significantly elevated risk of mortality. Clozapine is effective for treatment-resistant schizophrenia, but its use is limited by side-effects. Understanding its association with mortality risk…
View article: Anterior Cingulate Cortex Glutamate Levels and Sensory Integration Are Associated in Individuals With Social Anhedonia: A Comparison Between <scp>3T</scp> and <scp>7T MRS</scp>
Anterior Cingulate Cortex Glutamate Levels and Sensory Integration Are Associated in Individuals With Social Anhedonia: A Comparison Between <span>3T</span> and <span>7T MRS</span> Open
Deficits in schizophrenia are linked to abnormalities in the glutamate (Glu) system, which are believed to result in neurological soft signs (NSS) and negative symptoms. This study investigated the relationship between Glu levels of the an…
View article: Cerebellar–Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits
Cerebellar–Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits Open
Background and Hypothesis Motivational deficits are core negative symptoms of schizophrenia (SCZ), which have been linked to disruptions in reward network. Recent evidence suggests the cerebellum’s role in motivational and hedonic processi…
View article: A decade of Benzodiazepine and Z-drug use in Hong Kong: a longitudinal study
A decade of Benzodiazepine and Z-drug use in Hong Kong: a longitudinal study Open
No funding has been provided for this research.
View article: Efficient Adapter Tuning for Joint Singing Voice Beat and Downbeat Tracking with Self-supervised Learning Features
Efficient Adapter Tuning for Joint Singing Voice Beat and Downbeat Tracking with Self-supervised Learning Features Open
Singing voice beat tracking is a challenging task, due to the lack of musical accompaniment that often contains robust rhythmic and harmonic patterns, something most existing beat tracking systems utilize and can be essential for estimatin…
View article: Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task
Negative Schizotypy Associated With Weaker Intersubject Correlation in Dynamic Functional Connectivity During Empathic Accuracy Task Open
Background and Hypothesis Previous studies on Empathic Accuracy Task (EAT) suggested patients with schizophrenia exhibited altered brain activations in the precuneus, middle frontal gyrus, and thalamus. However, it remains unclear whether …
View article: The Relationship Among Range Adaptation, Social Anhedonia, and Social Functioning: A Combined Magnetic Resonance Spectroscopy and Resting-State fMRI Study
The Relationship Among Range Adaptation, Social Anhedonia, and Social Functioning: A Combined Magnetic Resonance Spectroscopy and Resting-State fMRI Study Open
Background and Hypothesis Social anhedonia is a core feature of schizotypy and correlates significantly with social functioning and range adaptation. Range adaptation refers to representing a stimulus value based on its relative position i…
View article: Relationship Between Schizotypal Traits, Emotion Regulation, and Negative Affect in Children: A Network Analysis
Relationship Between Schizotypal Traits, Emotion Regulation, and Negative Affect in Children: A Network Analysis Open
Background and Hypothesis Evidence suggests that emotion regulation is related to schizotypal traits and negative affect in adults. Few studies examined the interplay among these constructs in school-aged children. We examined the complex …
View article: Motivation and Pleasure Domain Links to Social Function in College Students: A Network Analysis
Motivation and Pleasure Domain Links to Social Function in College Students: A Network Analysis Open
Evidence suggests that the motivation and pleasure deficit of negative symptoms determines the social functioning in patients with schizophrenia spectrum disorder. Alexithymia is defined as the diminished ability to identify and describe e…
View article: Characterizing the Profile of Anhedonia in Individuals With Schizotypal Traits, Subthreshold Depression and Autistic Traits
Characterizing the Profile of Anhedonia in Individuals With Schizotypal Traits, Subthreshold Depression and Autistic Traits Open
Anhedonia is believed to be transdiagnostic symptom exist in various disorders including schizophrenia, major depressive disorder, and autism spectrum disorder. However, very few studies attempted to profile subclinical samples with schizo…
View article: Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study
Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study Open
Background and hypothesis Affective forecasting (AF), the ability to forecast emotional responses for future events, is critical for optimal decision-making and mental health. Most previous AF studies were conducted using laboratory-based …
View article: Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation
Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation Open
Background Second-generation antipsychotics (SGAs) cause metabolic side effects. However, patients’ metabolic profiles were influenced by time-invariant and time-varying confounders. Real-world evidence on the long-term, dynamic effects of…
View article: Integrating brain imaging features and genomic profiles for the subtyping of major depression
Integrating brain imaging features and genomic profiles for the subtyping of major depression Open
Background Precise stratification of patients into homogeneous disease subgroups could address the heterogeneity of phenotypes and enhance understanding of the pathophysiology underlying specific subtypes. Existing literature on subtyping …
View article: Uncovering the genetic underpinnings for different psychiatric disorder combinations
Uncovering the genetic underpinnings for different psychiatric disorder combinations Open
Background Psychiatric disorders are highly heterogeneous. It is clinically valuable to distinguish psychiatric disorders by the presence or absence of a specific comorbid condition. Methods We employed a novel algorithm (CombGWAS) to deci…
View article: Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation
Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation Open
Background Second-generation antipsychotics (SGAs) cause metabolic side-effects. However, patients’ metabolic profiles were influenced by many time-invariant and time-varying confounders. Real-world evidence on the long-term, dynamic effec…
View article: Mindfulness-based family psychoeducation intervention for caregivers of young adults with first-episode psychosis: results at 9-month follow-up
Mindfulness-based family psychoeducation intervention for caregivers of young adults with first-episode psychosis: results at 9-month follow-up Open
Objectives To investigate the effects of a mindfulness-based family psychoeducation (MBFPE) intervention on caregivers and the young adults with first-episode psychosis in mental health care. Methods Sixty-five caregivers were randomly ass…
View article: Pharmacogenetic Study of Antipsychotic-Induced Lipid and BMI Changes in Chinese Schizophrenia Patients: A Genome-Wide Association Study
Pharmacogenetic Study of Antipsychotic-Induced Lipid and BMI Changes in Chinese Schizophrenia Patients: A Genome-Wide Association Study Open
Second-generation antipsychotics (SGAs) are widely used to treat schizophrenia (SCZ), but they often induce metabolic side effects, including dyslipidemia and obesity, posing significant clinical challenges. While genetic factors are belie…
View article: Anhedonia Across and Beyond the Schizophrenia Spectrum
Anhedonia Across and Beyond the Schizophrenia Spectrum Open
Anhedonia refers to the diminished ability to experience pleasure, and is a core feature of schizophrenia (SCZ). The neurocognitive and neural correlates of anhedonia remain elusive. Based on several influential theoretical models for nega…
View article: Uncovering the genetic underpinnings for different psychiatric disorder combinations
Uncovering the genetic underpinnings for different psychiatric disorder combinations Open
Psychiatric disorders are highly heterogeneous. Clinically, it is meaningful to distinguish psychiatric disorders by the presence or absence of a specific comorbid condition. In this study, we employed a recently developed algorithm (CombG…
View article: A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology
A Transdiagnostic Network Analysis of Childhood Trauma and Psychopathology Open
Background and Hypothesis Psychiatric comorbidities suggest that symptoms overlap across different diagnoses; the transdiagnostic network approach is valuable for studying psychopathology. Childhood trauma is a common transdiagnostic risk …
View article: Factor analysis of the Chinese version of the Autism Spectrum Quotient 10 and its association with schizotypal traits in adolescents and young adults in Hong Kong
Factor analysis of the Chinese version of the Autism Spectrum Quotient 10 and its association with schizotypal traits in adolescents and young adults in Hong Kong Open
In Chinese adolescents and young adults, autistic traits, especially task switching and attention deficits (compared with theory of mind) are more closely correlated with schizotypal personality traits. Disentangling the overlapping and di…
View article: Interoception in mental disorders: from self-awareness to interventions
Interoception in mental disorders: from self-awareness to interventions Open
Interoception, the sense of the physiological condition of our body, has been proposed as a common vulnerability factor for psychopathology. Despite evidence confirming the relationship between interoception and a wide variety of clinical …
View article: Neuropsychology and Neurobiology of Negative Schizotypy: A Selective Review
Neuropsychology and Neurobiology of Negative Schizotypy: A Selective Review Open
Schizotypy refers to a latent personality organization that reflects liability to schizophrenia. Because schizotypy is a multidimensional construct, people with schizotypy vary in behavioral and neurobiological features. In this article, w…
View article: Empathic accuracy in individuals with schizotypal personality traits
Empathic accuracy in individuals with schizotypal personality traits Open
Empirical research using the Empathic Accuracy Task (EAT) has suggested that schizophrenia patients and people with schizotypal personality disorder exhibit lower empathic accuracy than healthy people. However, empathic accuracy in a subcl…
View article: Long-term Metabolic Side Effects of Second-Generation Antipsychotics in Chinese Patients with Schizophrenia: A Within-Subject Approach with modelling of dosage effects
Long-term Metabolic Side Effects of Second-Generation Antipsychotics in Chinese Patients with Schizophrenia: A Within-Subject Approach with modelling of dosage effects Open
Background Second-generation antipsychotics (SGAs) are commonly used to treat schizophrenia (SCZ), but SGAs may differ in the severity of side effects. Previous observational studies had limitations like failing to account for confounding …