Simon M. Brooke
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View article: Evaluation of a chemical genetic approach to be used in vivo to investigate the role of the M1 muscarinic acetylcholine receptor in learning, memory, and neurodegenerative disease
Evaluation of a chemical genetic approach to be used in vivo to investigate the role of the M1 muscarinic acetylcholine receptor in learning, memory, and neurodegenerative disease Open
In this project I performed the in vitro characterisation of a chemical genetic approach, using mutant receptors and an inert synthetic ligand, to dissect the role of the M1 muscarinic acetylcholine receptor (mAChR) in learning, memory, an…
View article: Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes Open
The realization of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands s…
View article: Author Index
Author Index Open
View article: An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory Open