Explanipedia

Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice Open

Chunhua Yang, Simon M. Mwangi, Arun Balasubramaniam, Ge Li, Olivier Merlin-Zhang , et al. · 2023

GDNF(pDNA)-loaded LNPs could potentially be developed as a therapeutic strategy to reverse weight gain in obese patients.

SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release Open

Arun Balasubramaniam, Philip R. Tedbury, Simon M. Mwangi, Yunshan Liu, Ge Li , et al. · 2023

Background: Diarrhea is present in up to 30–50% of patients with COVID-19. The mechanism of SARS-CoV-2-induced diarrhea remains unclear. We hypothesized that enterocyte–enteric neuron interactions were important in SARS-CoV-2-induced diarr…

SIRT3 activation promotes enteric neurons survival and differentiation Open

Arun Balasubramaniam, Ge Li, Anita Ramanathan, Simon M. Mwangi, C. Michael Hart , et al. · 2022

Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3 Open

Simon M. Mwangi, Ge Li, Arun Balasubramaniam, Didier Merlin, Paul A. Dawson , et al. · 2022

Palmitate and Western diet induce oxidative damage and impairment of mitophagy in hepatocytes - reversal by a neurotrophic factor Open

Simon M. Mwangi, Ge Li, Arun Balasubramaniam, Didier Merlin, Paul A. Dawson , et al. · 2022

Nonalcoholic fatty liver disease (NAFLD) is associated with increased oxidative stress that leads to hepatocyte and mitochondrial damage. In this study we investigated the mechanisms involved in the induction of oxidative stress and impair…

Sa1273: ENTERIC NEURONAL VASOACTIVE INTESTINAL PEPTIDE MEDIATES SARS-COV-2 ASSOCIATED DIARRHEA Open

Arun Balasubramaniam, Philip R. Tedbury, Adam D. Gracz, Simon M. Mwangi, Ge Li , et al. · 2022

Fr134 SARS-COV-2 INDUCES EPITHYELIAL-NEURONAL CROSSTALK STIMULATING VASOACTIVE INTESTINAL PEPTIDE RELEASE AS A POTENTIAL MECHANISM OF COVID-19-ASSOCIATED DIARRHEA Open

Peijian He, Philip R. Tedbury, Adam D. Gracz, Simon M. Mwangi, Ge Li , et al. · 2021

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System Open

Pavithra Chandramowlishwaran, Anitha Vijay, Daniel Abraham, Ge Li, Simon M. Mwangi , et al. · 2020

Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes. The molecular mechanisms of …

Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility Open

Lan Ye, Ge Li, Anna Goebel, Abhinav V. Raju, Feng Kong , et al. · 2020

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuron…

Glial Cell Line–Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity Open

Simon M. Mwangi, Ge Li, Lan Ye, Yunshan Liu, François Reichardt , et al. · 2019

Glial cell line–derived neurotrophic factor (GDNF) is a protein that is required for the development and survival of enteric, sympathetic, and catecholaminergic neurons. We previously reported that GDNF is protective against high fat diet …

Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid‐ and lipopolysaccharide‐induced TLR4 signalling Open

François Reichardt, Benoît Chassaing, Behtash Ghazi Nezami, Ge Li, Sahar Tabatabavakili , et al. · 2016

Key points A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota dysbiosis, which occurs in response to HFD, contribute…

Issue Information – TOC Open

Christine Koval, Erick Edwards, Ann Harper, Ryutaro Hirose, David C. Mulligan , et al. · 2016

for the Grupo de Estudio de Infecci on en Pacientes Trasplantados-Grupo de Estudio de Micolog ıa M edica (Sociedad Española de Enfermedades Infecciosas y Microbiolog ıa Cl ınica), and Red

Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice Open

Mallappa Anitha, François Reichardt, Sahar Tabatabavakili, Behtash Ghazi Nezami, Benoît Chassaing , et al. · 2016

Glial cell line–derived neurotrophic factor–induced mice liver defatting: A novel strategy to enable transplantation of steatotic livers Open

Sahar Taba Taba Vakili, Roshni Kailar, Khalidur Rahman, Behtash Ghazi Nezami, Simon M. Mwangi , et al. · 2015

Moderate macrovesicular steatosis (>30%), which is present in almost 50% of livers considered for transplantation, increases the risk of primary graft dysfunction. Our previously published data showed that glial cell line–derived neurotrop…

Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression Open

Simon M. Mwangi, Sophia Peng, Behtash Ghazi Nezami, Natalie Thorn, Alton B. Farris , et al. · 2015

Glial cell line-derived neurotrophic factor (GDNF) protects against high-fat diet (HFD)-induced hepatic steatosis in mice, however, the mechanisms involved are not known. In this study we investigated the effects of GDNF overexpression and…

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