Simon Massini
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View article: Cover Picture: Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids (Angew. Chem. Int. Ed. 26/2023)
Cover Picture: Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids (Angew. Chem. Int. Ed. 26/2023) Open
A methyltransferase from the green alga Chlamydomonas reinhardtii was identified and engineered for late-stage modifications of the carbon skeleton of terpenes. A variant with three changes in the amino acid sequence was able to produce me…
View article: Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids
Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids Open
Terpenoids are built from isoprene building blocks and have numerous biological functions. Selective late‐stage modification of their carbon scaffold has the potential to optimize or transform their biological activities. However, the synt…