Simón Méndez‐Ferrer
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View article: Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML
Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML Open
Juvenile myelomonocytic leukemia (JMML) originates from mutated hematopoietic stem cells. The mechanism by which mutant stem cells are sustained, leading to leukemia development, remains elusive. By comprehensively examining transcriptomic…
View article: Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment
Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment Open
Mobilization of hematopoietic stem cells (HSCs) is essential for successful stem cell transplantation but remains insufficient in a significant subset of patients. In this issue, Smith-Berdan et al. present a novel strategy using transient…
View article: Defective neutrophil clearance in <i>JAK2</i> <i>V617F</i> myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24
Defective neutrophil clearance in <i>JAK2</i> <i>V617F</i> myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24 Open
Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell–driven malignancies marked by excessive myelopoiesis and high risk of myelofibrosis, which remains therapeutically challenging. Senescent neutrophils home daily to the bone ma…
View article: eLife Assessment: Dynamic Tracking of Native Polyclonal Hematopoiesis in Adult Mice
eLife Assessment: Dynamic Tracking of Native Polyclonal Hematopoiesis in Adult Mice Open
Hematopoietic dysfunction has been associated with a reduction in the number of active precursors. However, precursor quantification at homeostasis and under diseased conditions is constrained by the scarcity of available methods. To addre…
View article: eLife Assessment: Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition
eLife Assessment: Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition Open
Overcoming drug-resistance and the subsequent relapse that often occurs with monotherapy is crucial in the treatment of acute myeloid leukemia. We here demonstrate that therapy-resistant leukemia initiating cells can be targeted using a no…
View article: eLife assessment: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
eLife assessment: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Article and author information Abstract Metabolic pathways are plas…
View article: IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i>-mutant hematopoietic stem cells
IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i>-mutant hematopoietic stem cells Open
JAK 2-V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). JAK2-V617F can be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much higher than the p…
View article: eLife Assessment: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
eLife Assessment: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: The Inflamed Niche: A Double-Edged Sword in AML?
The Inflamed Niche: A Double-Edged Sword in AML? Open
Summary: Although inflammation has long been recognized as a hallmark of many cancers, including acute myeloid leukemia (AML), how it affects individual cells of the tumor microenvironment and their interaction with normal and neoplastic c…
View article: IL-1β promotes MPN disease initiation by favoring early clonal expansion of<i>JAK2</i>-mutant hematopoietic stem cells
IL-1β promotes MPN disease initiation by favoring early clonal expansion of<i>JAK2</i>-mutant hematopoietic stem cells Open
JAK2 -V617F is the most frequent somatic mutation causing myeloproliferative neoplasm (MPN). However, JAK2 -V617F can also be found in healthy individuals with clonal hematopoiesis of indeterminate potential (CHIP) with a frequency much hi…
View article: Reviewer #2 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Reviewer #2 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: eLife Assessment: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
eLife Assessment: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Tamoxifen reduces mitochondrial respiration, oncogenic signaling and mutant allele burden in a myeloproliferative neoplasm subset
Tamoxifen reduces mitochondrial respiration, oncogenic signaling and mutant allele burden in a myeloproliferative neoplasm subset Open
Current therapies for myeloproliferative neoplasms (MPN) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem and progenitor cells (HSPCs). TAMARI…
View article: Editor's evaluation: Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Editor's evaluation: Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Acute lymphoblastic and myeloblastic…