Simon F. De Meyer
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View article: A novel p.C1130S mutation in a Finnish family with a complex phenotype of von Willebrand disease
A novel p.C1130S mutation in a Finnish family with a complex phenotype of von Willebrand disease Open
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View article: The Risks and Detection of Overestimated Privacy Protection in Voice Anonymisation
The Risks and Detection of Overestimated Privacy Protection in Voice Anonymisation Open
Voice anonymisation aims to conceal the voice identity of speakers in speech recordings. Privacy protection is usually estimated from the difficulty of using a speaker verification system to re-identify the speaker post-anonymisation. Perf…
View article: Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS
Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS Open
Allosteric regulation of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type-1 motif, member 13) activity involves an interaction between its spacer (S) and 2 complement C1r/C1s, Uegf and BMP1 (CUB; CUB1-2) domains to ke…
View article: Limited Impact of Drone Transport of Blood on Platelet Activation
Limited Impact of Drone Transport of Blood on Platelet Activation Open
The rapid transportation of blood samples and blood products using drones has high potential in the medical sector. However, before this can be implemented, sufficient evidence that drone transportation is not affecting clinical outcomes i…
View article: Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia–reperfusion injury in a mouse model of temporary middle cerebral artery occlusion—implications for neurovascular procedures
Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia–reperfusion injury in a mouse model of temporary middle cerebral artery occlusion—implications for neurovascular procedures Open
Background Several neurovascular procedures require temporary occlusion of cerebral arteries, leading to ischemia of unpredictable length, occasionally causing brain infarction. Experimental models of cerebral ischemia–reperfusion injury h…
View article: Use of geosynthetics and reduction of environmental impacts in the construction of a new parking apron at Ostend airport in Belgium
Use of geosynthetics and reduction of environmental impacts in the construction of a new parking apron at Ostend airport in Belgium Open
The theme of microplastics (MP) emissions is one of the focuses of possible environmental concerns when using geosynthetic products in the civil engineering applications. For the construction of a new aircraft parking apron at the Ostend a…
View article: Innovative woven geotextiles and geo fibres leading the sustainability path
Innovative woven geotextiles and geo fibres leading the sustainability path Open
The Beaulieu International Group has established a transparent way to communicate the environmental impact of their products. Via Environmental Product Declarations (EPDs), third party verified certifications and by following ISO 14025, th…
View article: OC 06.4 Therapeutic Efficacy of aNovel Humanized anti-ADAMTS13 Antibody to Treat Left Ventricular Assist Device-Induced Acquired Von Willebrand Syndrome
OC 06.4 Therapeutic Efficacy of aNovel Humanized anti-ADAMTS13 Antibody to Treat Left Ventricular Assist Device-Induced Acquired Von Willebrand Syndrome Open
Results: Eighteen studies were included in the final review for a total of 45 patients.The median age was 78 years (range: 21-93).The vast majority (75.6%) were males.Presenting bleeding symptoms were widely variable; the most common were …
View article: Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots
Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots Open
Background Studies during the COVID-19 pandemic have demonstrated an association between COVID-19 virus infection and the development of acute ischemic stroke, particularly large vessel occlusion (LVO). Studying the characteristics and imm…
View article: Identifying ex vivo acute ischemic stroke thrombus composition using electrochemical impedance spectroscopy
Identifying ex vivo acute ischemic stroke thrombus composition using electrochemical impedance spectroscopy Open
Background Intra-procedural characterization of stroke thromboemboli might guide mechanical thrombectomy (MT) device choice to improve recanalization rates. Electrochemical impedance spectroscopy (EIS) has been used to characterize various…
View article: Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity
Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity Open
Procoagulant platelets are associated with an increased risk for thrombosis. Procoagulant platelet formation is mediated via Cyclophilin D (CypD) mediated opening of the mitochondrial permeability transition pore. Inhibiting CypD activity …
View article: Graphical Abstract: Angew. Chem. Int. Ed. 16/2023
Graphical Abstract: Angew. Chem. Int. Ed. 16/2023 Open
In their Research Article (e202216478), Victor Gonzalez et al. report the detection and distribution of lead(II) formate
View article: Abstract Number ‐ 7: Final Angiographic, Clinical and Thrombus Composition Results of 1000 Patients in the EXCELLENT Registry
Abstract Number ‐ 7: Final Angiographic, Clinical and Thrombus Composition Results of 1000 Patients in the EXCELLENT Registry Open
Introduction EXCELLENT (NCT03685578; Cerenovus) is a large, prospective, international, real‐world registry of endovascular clot removal in acute ischemic stroke (AIS) with EmboTrap as the first line mechanical thrombectomy (MT) device, wh…
View article: TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD
TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology worldwide. In mice and humans, NAFLD progression is characterized by the appearance of TREM2-expressing macrophages in the liver. However, their mechanistic contri…
View article: Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke
Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke Open
This study identified the spatiotemporal profile of NET formation in a mouse model of cerebral I/R injury in ischemic stroke. NETs, potentially in combination with VWF, might be attractive targets for the development of novel therapeutic s…
View article: ADAMTS13 conformation and immunoprofiles in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura
ADAMTS13 conformation and immunoprofiles in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura Open
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an ultrarare thrombotic disease caused by autoantibody-induced ADAMTS13 deficiency. Open ADAMST13 conformation, induced by autoantibodies, was identified as a novel biomarker fo…
View article: High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium
High Incidence of SARS-CoV-2 Variant of Concern Breakthrough Infections Despite Residual Humoral and Cellular Immunity Induced by BNT162b2 Vaccination in Healthcare Workers: A Long-Term Follow-Up Study in Belgium Open
To mitigate the massive COVID-19 burden caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccination campaigns were initiated. We performed a single-center observational trial to monitor the mid- (3 months) a…
View article: Unusual Histopathological Findings in Mechanically Removed Stroke Thrombi – A Multicenter Experience
Unusual Histopathological Findings in Mechanically Removed Stroke Thrombi – A Multicenter Experience Open
Background Several studies have investigated the histopathology of mechanically retrieved thrombi from stroke patients. Thrombi with unusual components constitute about 1–2% of all stroke thrombi in clinical practice. Knowledge about these…
View article: Passivated Impedimetric Sensors for Immobilization-Free Pathogen Detection by Isothermal Amplification and Melt Curve Analysis
Passivated Impedimetric Sensors for Immobilization-Free Pathogen Detection by Isothermal Amplification and Melt Curve Analysis Open
The ongoing SARS-CoV-2 pandemic demonstrates that the capacity of centralized clinical diagnosis laboratories represents a significant limiting factor in the global fight against the newly emerged virus. Scaling up these capacities also re…