Simon Perrin
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View article: Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1
Pharmacological inhibition of RAS pathway alleviates spine deformity in a mouse model of neurofibromatosis type 1 Open
Neurofibromatosis type 1 (NF1) is a genetic disorder affecting 1 in 3 000 people due to heterozygous mutations in the NF1 gene. Patients with NF1 can develop multiple symptoms, such as neurofibromas, skin hyperpigmentation, and bone abnorm…
View article: Nuclei Isolation From Murine and Human Periosteum For Transcriptomic Analyses
Nuclei Isolation From Murine and Human Periosteum For Transcriptomic Analyses Open
Bone repair is a complex regenerative process relying on skeletal stem/progenitor cells (SSPCs) recruited predominantly from the periosteum. Activation and differentiation of periosteal SSPCs occur in a heterogeneous environment, raising t…
View article: Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration Open
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly u…
View article: Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration Open
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly u…
View article: MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by <i>NF1</i> loss in Schwann cells and skeletal stem/progenitor cells
MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by <i>NF1</i> loss in Schwann cells and skeletal stem/progenitor cells Open
Congenital pseudarthrosis of the tibia (CPT) is a severe pathology marked by spontaneous bone fractures that fail to heal, leading to fibrous nonunion. Half of patients with CPT are affected by the multisystemic genetic disorder neurofibro…
View article: Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma Open
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion. The impact of MTI on the inflammatory response to fracture and on the immunomodulation of skeletal stem/progenito…
View article: Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration Open
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly u…
View article: Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration Open
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPCs activation and differentiation remain poorly …
View article: Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration
Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration Open
Bone regeneration is mediated by skeletal stem/progenitor cells (SSPCs) that are mainly recruited from the periosteum after bone injury. The composition of the periosteum and the steps of SSPC activation and differentiation remain poorly u…
View article: Role of periosteum in bone regeneration and congenital pseudarthrosis of the tibia
Role of periosteum in bone regeneration and congenital pseudarthrosis of the tibia Open
Bone repair is a highly efficient process allowing bones to fully regenerate without scarring after fracture. It relies on the activation and differentiation of skeletal stem/progenitor cells (SSPCs) recruited locally from the periosteum, …
View article: Mouse Periosteal Cell Culture, in vitro Differentiation, and in vivo Transplantation in Tibial Fractures
Mouse Periosteal Cell Culture, in vitro Differentiation, and in vivo Transplantation in Tibial Fractures Open
The periosteum covering the outer surface of bone contains skeletal stem/progenitor cells that can efficiently form cartilage and bone during bone repair. Several methods have been described to isolate periosteal cells based on bone scrapi…
View article: Skeletal Stem/Progenitor Cells in Periosteum and Skeletal Muscle Share a Common Molecular Response to Bone Injury
Skeletal Stem/Progenitor Cells in Periosteum and Skeletal Muscle Share a Common Molecular Response to Bone Injury Open
Bone regeneration involves skeletal stem/progenitor cells (SSPCs) recruited from bone marrow, periosteum, and adjacent skeletal muscle. To achieve bone reconstitution after injury, a coordinated cellular and molecular response is required …
View article: Association d’un bloc saphène au canal des adducteurs et d’une infiltration périarticulaire chirurgicale pour la pose de prothèse totale du genou : Stratégies analgésiques en chirurgie prothétique du genou et étude comparative
Association d’un bloc saphène au canal des adducteurs et d’une infiltration périarticulaire chirurgicale pour la pose de prothèse totale du genou : Stratégies analgésiques en chirurgie prothétique du genou et étude comparative Open
Introduction : Continuous femoral nerve block (CFNB) is the current gold standard in postoperative analgesia after total knee arthroplasty, but in case of quadriceps motor block it can hamper early rehabilitation and increase the risk of f…