Simon Harding
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View article: Surface glare suppression in retinal imaging with a cross-polarized line-scanning color fundus camera
Surface glare suppression in retinal imaging with a cross-polarized line-scanning color fundus camera Open
Fundus imaging is critical for the early detection and management of retinal diseases, yet cost and technical limitations remain barriers to broad implementation, especially in resource-limited settings. Conventional fundus photography and…
View article: Functional and structural biomarkers linked to diabetic retinal neurodegeneration in pre-clinical and early diabetic retinopathy
Functional and structural biomarkers linked to diabetic retinal neurodegeneration in pre-clinical and early diabetic retinopathy Open
View article: Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study
Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study Open
Background Previous work has identified that malarial retinopathy has diagnostic value in paediatric cerebral malaria (CM). To improve our understanding of malarial retinopathy as a predictor of cerebral parasite sequestration in paediatri…
View article: Cost‐effectiveness of fenofibrate versus standard care for reducing the progression of diabetic retinopathy: An economic evaluation based on data from the <scp>LENS</scp> trial
Cost‐effectiveness of fenofibrate versus standard care for reducing the progression of diabetic retinopathy: An economic evaluation based on data from the <span>LENS</span> trial Open
Aims The LENS trial demonstrated that fenofibrate slowed the progression of diabetic retinopathy compared to placebo in participants with early diabetic eye disease. We assessed its cost‐effectiveness for reducing the progression of diabet…
View article: Water uptake behaviour of semiconducting glasses formed from hybrid organic–inorganic perovskites
Water uptake behaviour of semiconducting glasses formed from hybrid organic–inorganic perovskites Open
Here we present the uptake behaviour of mechanochemically synthesised crystalline HOIPs, of the form [TAlA][M(dca)3] (TAlA= tetraalkylammonium, M= Mn2+ and Fe2+, dca= [C2N3-] (dicyanamide)), and their stable melt quenched glassy derivative…
View article: Water uptake behaviour of semiconducting glasses formed from hybrid organic–inorganic perovskites
Water uptake behaviour of semiconducting glasses formed from hybrid organic–inorganic perovskites Open
Here we present the uptake behaviour of mechanochemically synthesised crystalline HOIPs, of the form [TAlA][M(dca)3] (TAlA= tetraalkylammonium, M= Mn2+ and Fe2+, dca= [C2N3-] (dicyanamide)), and their stable melt quenched glassy derivative…
View article: Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology Open
View article: Glare Suppression in Retinal Imaging with a Cross-Polarized Line-Scanning Colour Fundus Camera
Glare Suppression in Retinal Imaging with a Cross-Polarized Line-Scanning Colour Fundus Camera Open
View article: Re-evaluating malarial retinopathy to improve its diagnostic accuracy in cerebral malaria
Re-evaluating malarial retinopathy to improve its diagnostic accuracy in cerebral malaria Open
Background Previous work has identified that malarial retinopathy (MR) has diagnostic value in cerebral malaria (CM). To improve our understanding of MR as a predictor of cerebral parasite sequestration in CM we reviewed data from the Blan…
View article: Bottom-Up Computational Design of Shape-Selective Organic Macrocycles for Humid CO2 Capture
Bottom-Up Computational Design of Shape-Selective Organic Macrocycles for Humid CO2 Capture Open
The capture of carbon dioxide (CO2) emissions using porous solids is challenging because polarized water molecules bind more strongly in most materials than non-polarized CO2 molecules. This is a challenge for both flue gas capture and for…
View article: Effect of Fenofibrate on Progression of Diabetic Retinopathy
Effect of Fenofibrate on Progression of Diabetic Retinopathy Open
Fenofibrate reduced progression of diabetic retinopathy compared with placebo among participants with early retinal changes. (Funded by the National Institute for Health and Care Research; ClinicalTrials.gov number, NCT03439345; ISRCTN num…
View article: The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population
The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population Open
View article: Convolutional neural network-based classification of glaucoma using optic radiation tissue properties
Convolutional neural network-based classification of glaucoma using optic radiation tissue properties Open
View article: The future of academic integrity in the age of artificial intelligence
The future of academic integrity in the age of artificial intelligence Open
View article: Periodontitis and Outer Retinal Thickness: a Cross-Sectional Analysis of the United Kingdom Biobank Cohort
Periodontitis and Outer Retinal Thickness: a Cross-Sectional Analysis of the United Kingdom Biobank Cohort Open
View article: In Vitro Characterisation of Endothelial Colony Forming Cells (Ecfcs) from a Cohort of Patients with Diabetic Retinopathy
In Vitro Characterisation of Endothelial Colony Forming Cells (Ecfcs) from a Cohort of Patients with Diabetic Retinopathy Open
View article: Individualised variable-interval risk-based screening in diabetic retinopathy: the ISDR research programme including RCT
Individualised variable-interval risk-based screening in diabetic retinopathy: the ISDR research programme including RCT Open
Background Systematic annual screening for sight-threatening diabetic retinopathy is established in several countries but is resource intensive. Personalised (individualised) medicine offers the opportunity to extend screening intervals fo…
View article: A foundation model for generalizable disease detection from retinal images
A foundation model for generalizable disease detection from retinal images Open
View article: Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants
Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants Open
Importance Calcium channel blocker (CCB) use has been associated with an increased risk of glaucoma in exploratory studies. Objective To examine the association of systemic CCB use with glaucoma and related traits among UK Biobank particip…
View article: Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease
Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease Open
Individuals with PD have reduced thickness of the INL and GCIPL of the retina. Involvement of these layers several years before clinical presentation highlight a potential role for retinal imaging for at-risk stratification of PD.
View article: Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden
Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden Open
Importance Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication. Objective To evaluate phenotypic features across genetic burden for POAG.…
View article: Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children
Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children Open
Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of …
View article: SPIRIT Checklist & Model Consent for 'Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children'
SPIRIT Checklist & Model Consent for 'Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children' Open
This dataset contains the SPIRIT checklist (adapted to a observational trial) and model consent forms for the OCT in CM study protocol. The protocol will be submitted as a paper to Wellcome Open Research.
View article: SPIRIT Checklist & Model Consent for 'Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children'
SPIRIT Checklist & Model Consent for 'Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) – A protocol for an observational cohort study of Malawian children' Open
This dataset contains the SPIRIT checklist (adapted to a observational trial) and model consent forms for the OCT in CM study protocol. The protocol will be submitted as a paper to Wellcome Open Research.
View article: Correction: UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases
Correction: UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases Open
The wrong Supplementary file was originally published with this article; it has now been replaced with the correct file. The original article has been corrected.
View article: The Association of Alcohol Consumption with Glaucoma and Related Traits
The Association of Alcohol Consumption with Glaucoma and Related Traits Open
View article: UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases
UK Biobank retinal imaging grading: methodology, baseline characteristics and findings for common ocular diseases Open
View article: The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts
The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts Open
View article: Long-term Retinal Morphology and Functional Associations in Treated Neovascular Age-Related Macular Degeneration
Long-term Retinal Morphology and Functional Associations in Treated Neovascular Age-Related Macular Degeneration Open
View article: Associations of Alcohol Consumption and Smoking With Disease Risk and Neurodegeneration in Individuals With Multiple Sclerosis in the United Kingdom
Associations of Alcohol Consumption and Smoking With Disease Risk and Neurodegeneration in Individuals With Multiple Sclerosis in the United Kingdom Open
These findings suggest that high alcohol intake was associated with retinal features indicative of more severe neurodegeneration, whereas smoking was associated with higher odds of being diagnosed with MS.