Simon E. V. Phillips
YOU?
Author Swipe
View article: Can artificial intelligence support Bactrian camel conservation? Testing machine learning on aerial imagery in Mongolia’s Gobi Desert
Can artificial intelligence support Bactrian camel conservation? Testing machine learning on aerial imagery in Mongolia’s Gobi Desert Open
Summary Monitoring wildlife populations in vast, remote landscapes poses significant challenges for conservation and management, particularly when studying elusive species that range across inaccessible terrain. Traditional survey methods …
View article: Visualizing Viral RNA Packaging Signals in Action
Visualizing Viral RNA Packaging Signals in Action Open
Here we confirm, using genome-scale RNA fragments in assembly competition assays, that multiple sub-sites (Packaging Signals, PSs) across the 5' two-thirds of the gRNA of Satellite Tobacco Necrosis Virus-1 make sequence-specific contacts t…
View article: Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells Open
Supplementary Figures 1-7
View article: Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells Open
Purpose:Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or imm…
View article: Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Data from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells Open
Purpose:Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or imm…
View article: Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Supplementary Figures from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells Open
Supplementary Figures 1-7
View article: Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells
Supplementary Tables from Cancer Antigen Discovery Is Enabled by RNA Sequencing of Highly Purified Malignant and Nonmalignant Cells Open
Supplementary Tables 1-9
View article: Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds Open
The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein–protein interactions. We have refined crystallization condition…
View article: BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions Open
The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be …
View article: Author response: BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions
Author response: BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The RAS family of proteins is…
View article: Rewriting nature’s assembly manual for a ssRNA virus
Rewriting nature’s assembly manual for a ssRNA virus Open
Significance Viruses composed of a shell of coat proteins enclosing ssRNA genomes are among the simplest biological entities. Their lifecycles include a range of processes, such as specific genome encapsidation and efficient capsid self-as…
View article: Structural basis for DNA recognition by the transcription regulator MetR
Structural basis for DNA recognition by the transcription regulator MetR Open
MetR, a LysR-type transcriptional regulator (LTTR), has been extensively studied owing to its role in the control of methionine biosynthesis in proteobacteria. A MetR homodimer binds to a 24-base-pair operator region of the met genes and s…