Simon R. Platt
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View article: Meningoencephalitis of unknown origin with predominant cerebellar involvement in a cat: clinical, MRI and pathological findings
Meningoencephalitis of unknown origin with predominant cerebellar involvement in a cat: clinical, MRI and pathological findings Open
Case summary Meningoencephalitis of unknown origin (MUO) is a term encompassing non-infectious inflammatory brain diseases with no identifiable underlying cause, widely studied in dogs but rarely in cats. This case describes a 9-year-old m…
View article: Preoperative Ankle Swelling and the Effect On Postoperative Wound Complications Following Ankle Fracture Surgery
Preoperative Ankle Swelling and the Effect On Postoperative Wound Complications Following Ankle Fracture Surgery Open
Background Swelling following an ankle fracture is commonly believed to preclude surgical fixation; swelling is thought to be associated with increased wound complications. Delaying surgery until swelling subsides is thought to secure bett…
View article: Magnetic Resonance Imaging Characteristics of Hereditary Polymyositis in the Dutch Kooiker Dog
Magnetic Resonance Imaging Characteristics of Hereditary Polymyositis in the Dutch Kooiker Dog Open
Background: Hereditary immune-mediated polymyositis has been reported in the Kooiker dog breed, associated with a 39 kb deletion and low penetrance. Approximately 10–20 percent of homozygous dogs and 0.5–2 percent of heterozygous dogs deve…
View article: “I just want to get it done”—a mixed-methods study on how people undergoing hallux valgus surgery perceive risk
“I just want to get it done”—a mixed-methods study on how people undergoing hallux valgus surgery perceive risk Open
Background This scoping study explored patients’ preoperative perspectives of their expectations, their tolerance for risk, and what factors may influence their decision to undergo hallux valgus surgery. Methods Recently consented patients…
View article: Hemorrhagic encephalopathies and myelopathies in dogs and cats: a focus on classification
Hemorrhagic encephalopathies and myelopathies in dogs and cats: a focus on classification Open
The prevalence of hemorrhagic diseases of the central nervous system of dogs and cats is low compared to other diseases such as neoplasia and inflammation. However, the clinical consequences can be devastating. Several etiological and loca…
View article: Granuloprival cerebellar cortical degeneration in a <scp>Yorkshire Terrier</scp> and <scp>Lagotto Romagnolo</scp> dog
Granuloprival cerebellar cortical degeneration in a <span>Yorkshire Terrier</span> and <span>Lagotto Romagnolo</span> dog Open
Granuloprival degeneration is an uncommon form of cerebellar cortical degeneration (CCD). A 3‐month‐old Yorkshire Terrier and a 7‐month‐old Lagotto Romagnolo dog were presented with a history of progressive cerebellar dysfunction including…
View article: <scp>ACVIM</scp> Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats
<span>ACVIM</span> Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats Open
Background Seizure emergencies (ie, status epilepticus [SE] and cluster seizures [CS]), are common challenging disorders with complex pathophysiology, rapidly progressive drug‐resistant and self‐sustaining character, and high morbidity and…
View article: Association of the <scp><i>FGF4L2</i></scp> retrogene with fibrocartilaginous embolic myelopathy in dogs
Association of the <span><i>FGF4L2</i></span> retrogene with fibrocartilaginous embolic myelopathy in dogs Open
Background Fibrocartilaginous embolic myelopathy (FCE) is a well‐documented condition in dogs although rarely reported in chondrodystrophic breeds. Genetic associations have not been defined. Objectives Define the association of the chondr…
View article: Case report: Traumatic hemorrhagic cervical myelopathy in a dog
Case report: Traumatic hemorrhagic cervical myelopathy in a dog Open
A 1.5-year-old female entire French bulldog was referred for neurological evaluation, further diagnostic tests, and treatment 24 h after a road traffic accident. Initial emergency treatment, diagnostic tests, and stabilization had been per…
View article: Ligamentous Injuries in Stable Ankle Fractures
Ligamentous Injuries in Stable Ankle Fractures Open
Category: Ankle; Trauma Introduction/Purpose: When considering ankle fractures requiring fixation, it has been shown that stability is the key determinant. Lauge-Hansen supination external rotation (SER) 2 injuries are by definition stable…
View article: Glioma with cribriform plate involvement in 6 dogs
Glioma with cribriform plate involvement in 6 dogs Open
Distinct patterns of local infiltration are a common feature of canine oligodendroglioma and astrocytoma, and typically involve the surrounding neuroparenchyma, ventricles, or leptomeninges. Infiltration of adjacent extraneural sites is ra…
View article: Case report: Surgical treatment and long-term successful outcome of a spinal intramedullary vascular malformation in a dog
Case report: Surgical treatment and long-term successful outcome of a spinal intramedullary vascular malformation in a dog Open
A 3.5-year-old male intact Staffordshire terrier crossbreed dog was presented with a one-week history of progressive paraparesis with fecal and urinary incontinence. Neurological examination was consistent with a T3-L3 myelopathy. A magnet…
View article: Accidental intraspinal microchip implant in a cat
Accidental intraspinal microchip implant in a cat Open
View article: Multiplex analysis of cytokines in the cerebrospinal fluid of dogs after ischemic stroke reveals elevations in chemokines CXCL1 and MCP-1
Multiplex analysis of cytokines in the cerebrospinal fluid of dogs after ischemic stroke reveals elevations in chemokines CXCL1 and MCP-1 Open
Introduction Neuroinflammation that occurs in the brain after stroke has been shown to be important to disease pathogenesis and outcomes. The aim of this study was to evaluate a large number of pro- and anti-inflammatory cytokines in dogs …
View article: Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model
Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model Open
Impaired gut homeostasis is associated with stroke often presenting with leaky gut syndrome and increased gut, brain, and systemic inflammation that further exacerbates brain damage. We previously reported that intracisternal administratio…
View article: Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies
Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies Open
Background: Atlanto-axial (AA) subluxation can be a complex syndrome in dogs. Accurate identification and assessment of this condition is key to providing treatment and resolution. Aim: The purpose of this retrospective study was to descri…
View article: Advancements in drug delivery methods for the treatment of brain disease
Advancements in drug delivery methods for the treatment of brain disease Open
The blood-brain barrier (BBB) presents a formidable obstacle to the effective delivery of systemically administered pharmacological agents to the brain, with ~5% of candidate drugs capable of effectively penetrating the BBB. A variety of b…
View article: Magnetic resonance imaging and pathological characteristics of <i>Cladophialophora</i> encephalitis in a young dog
Magnetic resonance imaging and pathological characteristics of <i>Cladophialophora</i> encephalitis in a young dog Open
A 1‐year‐old dog was presented for persistent neck pain and circling. Magnetic resonance imaging revealed a large, space‐occupying, intra‐axial mass with extensive surrounding vasogenic oedema affecting the left thalamus and hippocampus. P…
View article: Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Model
Tanshinone IIA-Loaded Nanoparticle and Neural Stem Cell Therapy Enhances Recovery in a Pig Ischemic Stroke Model Open
Induced pluripotent stem cell-derived neural stem cells (iNSCs) are a multimodal stroke therapeutic that possess neuroprotective, regenerative, and cell replacement capabilities post-ischemia. However, long-term engraftment and efficacy of…
View article: Seawater exposure to surgical wounds: an alarming patient perspective
Seawater exposure to surgical wounds: an alarming patient perspective Open
Background There is a wealth of microorganisms that are causative for bone and soft tissue infections. Wounds sustained in, or exposed to, marine environments are unique in regards to the spectrum of bacteria encountered in these environme…
View article: Tanshinone IIA and Neural Stem Cell Combination Therapy Decreases Gut Inflammation and Maintains Gut Integrity in a Translational Pig Ischemic Stroke Model
Tanshinone IIA and Neural Stem Cell Combination Therapy Decreases Gut Inflammation and Maintains Gut Integrity in a Translational Pig Ischemic Stroke Model Open
View article: “I'd never have that operation again” – a mixed‐methods study on how patients react to adverse outcomes following foot and ankle surgery
“I'd never have that operation again” – a mixed‐methods study on how patients react to adverse outcomes following foot and ankle surgery Open
Background Adverse outcomes arising from foot and ankle surgery, including lack of pain relief, increased disability and perioperative complications are infrequent but inevitable. This mixed‐methods study aims to explore the impact of adve…
View article: A Systematic Review of Randomized Controlled Trials in Anterior Cruciate Ligament Reconstruction: Standard Techniques Are Comparable (299 Trials With 25,816 Patients)
A Systematic Review of Randomized Controlled Trials in Anterior Cruciate Ligament Reconstruction: Standard Techniques Are Comparable (299 Trials With 25,816 Patients) Open
Level II; systematic review of Level I-II randomized controlled trials.
View article: Peri‐ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy
Peri‐ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy Open
Background The pathophysiology of changes in magnetic resonance imaging (MRI) detected after a seizure is not fully understood. Objective To characterize and describe seizure‐induced changes detected by MRI. Animals Eighty‐one client‐owned…
View article: Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke
Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke Open
The findings of this proof of concept study strongly suggest that administration of Tan IIA-NPs in the acute phase post-stroke mitigates neural injury likely through limiting free radical formation, thus leading to less severe gait deficit…
View article: Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study
Canine cognitive dysfunction patients have reduced total hippocampal volume compared with aging control dogs: A comparative magnetic resonance imaging study Open
Background: Hippocampal atrophy is a key pathologic and magnetic resonance imaging (MRI) feature of human Alzheimer’s disease (AD). Hippocampal atrophy has not been documented via MRI in canine cognitive dysfunction (CCD), which is conside…
View article: Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing IL-12, in pet dogs with sporadic gliomas
Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing IL-12, in pet dogs with sporadic gliomas Open
OBJECTIVE The diagnosis of glioma remains disheartening in the clinical realm. While a multitude of studies and trials have shown promise, improvements in overall survival have been disappointing. Modeling these tumors in the laboratory se…
View article: Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models
Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models Open
The Stroke Therapy Academic Industry Roundtable (STAIR) has recommended that novel therapeutics be tested in a large animal model with similar anatomy and physiology to humans. The pig is an attractive model due to similarities in brain si…
View article: A Bibliometric Analysis of 4 Major Foot and Ankle Surgery Journals
A Bibliometric Analysis of 4 Major Foot and Ankle Surgery Journals Open
View article: Evaluation of immunologic parameters in canine glioma patients treated with an oncolytic herpes virus
Evaluation of immunologic parameters in canine glioma patients treated with an oncolytic herpes virus Open
Aim: To molecularly characterize the tumor microenvironment and evaluate immunologic parameters in canine glioma patients before and after treatment with oncolytic human IL-12-expressing herpes simplex virus (M032) and in treatment naïve c…