Simon Rinaldi
YOU?
Author Swipe
View article: The potential role of IgG subclass in NF155-associated nodopathy for targeting therapy: a pediatric case report highlighting the efficacy of pulsed oral corticosteroids
The potential role of IgG subclass in NF155-associated nodopathy for targeting therapy: a pediatric case report highlighting the efficacy of pulsed oral corticosteroids Open
View article: Die Immunologie und Neuropathologie der autoimmunen Nodopathien
Die Immunologie und Neuropathologie der autoimmunen Nodopathien Open
Die autoimmunen Nodopathien haben sich in jüngster Zeit als eigenständiger Subtyp der entzündlichen Neuropathie herauskristallisiert. Sie sind durch das Vorhandensein von Autoantikörpern der Klasse IgG gekennzeichnet, die gegen strukturell…
View article: Enhanced adenoviral reactivity in Guillain-Barré syndrome after SARS-CoV-2 infection and vaccination
Enhanced adenoviral reactivity in Guillain-Barré syndrome after SARS-CoV-2 infection and vaccination Open
Case reports and series suggested an association between SARS-CoV-2 and Guillain-Barré syndrome (GBS). However, the GBS epidemic which was predicted from early risk estimates did not materialise in overall case numbers, and no plausible me…
View article: Chronic Inflammatory Demyelinating Polyradiculoneuropathy ( <scp>CIDP</scp> ) Developing During Tacrolimus Treatment: A Case Series
Chronic Inflammatory Demyelinating Polyradiculoneuropathy ( <span>CIDP</span> ) Developing During Tacrolimus Treatment: A Case Series Open
Introduction/Aims Chronic Inflammatory Demyelinating Polyradiculoneuropathy ( CIDP ) can occasionally emerge during treatment with tacrolimus, a commonly used immunosuppressant for solid organ transplantation, and this association is poorl…
View article: Real‐World Multinational Survey of Chronic Inflammatory Demyelinating Polyneuropathy: Disease Characteristics and Therapeutic Landscape
Real‐World Multinational Survey of Chronic Inflammatory Demyelinating Polyneuropathy: Disease Characteristics and Therapeutic Landscape Open
Background and Aims Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune‐mediated syndrome characterized by progressive muscle weakness and sensory impairment. Clinical similarities with other neuropathies can cause misdia…
View article: NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons
NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons Open
Nociceptors are primary afferent neurons that sense noxious stimuli. They can be activated by tissue injury as well as the accompanying local immune response. We have shown that following nerve injury in mice cytotoxic Natural Killer (NK) …
View article: Plasma periaxin is a biomarker of peripheral nerve demyelination
Plasma periaxin is a biomarker of peripheral nerve demyelination Open
Assessing disease progression and informing clinical trials in peripheral neuropathy would benefit from objective and responsive fluid biomarkers closely linked to disease biology. This is particularly important in chronic inflammatory dem…
View article: Case Report: Pediatric age onset CNTN1 antibody-associated neuropathy with nephropathy and literature review
Case Report: Pediatric age onset CNTN1 antibody-associated neuropathy with nephropathy and literature review Open
We present a 12-year-old boy with acute onset sensorimotor neuropathy and membranous glomerulonephritis associated with contactin-1 antibodies. This prompted us to explore the clinical characteristics of this condition and assess whether i…
View article: The immunology and neuropathology of the autoimmune nodopathies
The immunology and neuropathology of the autoimmune nodopathies Open
The autoimmune nodopthies have recently emerged as a discrete subtype of inflammatory neuropathy. They are characterised by the presence of IgG class autoantibodies directed against structural components of the node of Ranvier, such as the…
View article: P.033 Long-term efficacy of Efgartigimod PH20 SC in patients with chronic inflammatory demyelinating polyneuropathy: interim results from the ADHERE+ study
P.033 Long-term efficacy of Efgartigimod PH20 SC in patients with chronic inflammatory demyelinating polyneuropathy: interim results from the ADHERE+ study Open
Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP). The multi-stage, double-blinded, placebo-con…
View article: D.7 Efgartigimod impact on I-RODS daily activity assessment in chronic inflammatory demyelinating polyneuropathy: post hoc analysis of Registrational ADHERE Study
D.7 Efgartigimod impact on I-RODS daily activity assessment in chronic inflammatory demyelinating polyneuropathy: post hoc analysis of Registrational ADHERE Study Open
Background: Efgartigimod, a human immunoglobulin (Ig)G1 antibody Fc fragment, blocks the neonatal Fc receptor, reducing IgGs involved in chronic inflammatory demyelinating polyneuropathy (CIDP), a rare, progressive, immune-mediated disease…
View article: Immunology of the peripheral nervous system: the inflammatory neuropathies
Immunology of the peripheral nervous system: the inflammatory neuropathies Open
View article: Assessment of Analytical Specificity in qPCR: SYBR Green and TaqMan Probe Methods for Isonazid-Resistant Mycobacterium tuberculosis
Assessment of Analytical Specificity in qPCR: SYBR Green and TaqMan Probe Methods for Isonazid-Resistant Mycobacterium tuberculosis Open
Background & Objective: Mycobacterium tuberculosis, often referred to as M. tuberculosis, is an infectious pathogen that is responsible for causing tuberculosis (TB), a prevalent condition that is a leading cause of death globally. The spr…
View article: Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the development of disease-causing B cells and autoantibodies. Convention suggests that such autoreactivities are generated…
View article: Diagnosis and Management of Multifocal Motor Neuropathy in the United Kingdom: A Multicentre Survey
Diagnosis and Management of Multifocal Motor Neuropathy in the United Kingdom: A Multicentre Survey Open
Background We conducted a survey to determine the current diagnosis and treatment of multifocal motor neuropathy (MMN) in the United Kingdom. Methods Demographic, diagnostic and treatment data were collected at nine UK neuroscience centres…
View article: Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome
Large-scale profiling of antibody reactivity to glycolipids in patients with Guillain-Barré syndrome Open
Guillain-Barré syndrome is an acute polyradiculoneuropathy in which preceding infections often elicit the production of antibodies that target peripheral nerve antigens, principally gangliosides. Anti-ganglioside antibodies are thought to …
View article: Inter‐Laboratory Validation of Nodal/Paranodal Antibody Testing
Inter‐Laboratory Validation of Nodal/Paranodal Antibody Testing Open
Background and Aims Reliable detection of antibodies against nodal targets is vital for the diagnosis of autoimmune nodopathies. The performance characteristics of recently developed in‐house assays are unknown. We compared testing at four…
View article: Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and …
View article: Clinical Features and Management of Optic Neuritis in a Cohort of South African Patients with Combined Central and Peripheral Demyelination
Clinical Features and Management of Optic Neuritis in a Cohort of South African Patients with Combined Central and Peripheral Demyelination Open
View article: Combined central and peripheral demyelination in two siblings, immune mediated or genetic?
Combined central and peripheral demyelination in two siblings, immune mediated or genetic? Open
We report unusual cases of combined central and peripheral demyelination in two siblings related to pregnancy, each presenting with progressive tetraparesis and cranial nerve palsies. The elder sister had a relapsing–remitting course with …
View article: <scp>Guillain‐Barré</scp> syndrome: a comprehensive review
<span>Guillain‐Barré</span> syndrome: a comprehensive review Open
Guillain‐Barré syndrome (GBS) is a potentially devastating yet treatable disorder. A classically postinfectious, immune‐mediated, monophasic polyradiculoneuropathy, it is the leading global cause of acquired neuromuscular paralysis. In mos…
View article: CIDP trials and tribulations
CIDP trials and tribulations Open
View article: Periaxin is a Biomarker of Peripheral Nerve Demyelination
Periaxin is a Biomarker of Peripheral Nerve Demyelination Open
View article: Pathologic <i>RFC1</i> repeat expansions do not contribute to the development of inflammatory neuropathies
Pathologic <i>RFC1</i> repeat expansions do not contribute to the development of inflammatory neuropathies Open
Biallelic expansions of the AAGGG repeat in the replication factor C subunit 1 (RFC1) have recently been described to be responsible for cerebellar ataxia, peripheral neuropathy and vestibular areflexia syndrome. This genetic alteration ha…
View article: Reply: Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation
Reply: Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation Open
We are grateful to Dr Berciano for his exposition on the pathogenesis of Guillain-Barre 1 syndrome, drawing together our findings on the rise in peripherin with a short and early time 2 course with the important historical clinical and ani…
View article: Peripherin is a biomarker of axonal damage in peripheral nervous system disease
Peripherin is a biomarker of axonal damage in peripheral nervous system disease Open
Valid, responsive blood biomarkers specific to peripheral nerve damage would improve management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) is sensitive for detecting axonal pathology but is not specific to…
View article: Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons
Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons Open
Traumatic peripheral nerve injuries are at high risk of neuropathic pain for which novel effective therapies are urgently needed. Preclinical models of neuropathic pain typically involve irreversible ligation and/or nerve transection (neur…
View article: CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome
CSF Findings in Relation to Clinical Characteristics, Subtype, and Disease Course in Patients With Guillain-Barré Syndrome Open
This study provides Class IV evidence that CSF ACD (defined by the Brighton Collaboration) is common in patients with GBS.
View article: Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis
Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis Open
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association bet…
View article: Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies
Guillain-Barré Syndrome Following Zika Virus Infection Is Associated With a Diverse Spectrum of Peripheral Nerve Reactive Antibodies Open
Autoantibody responses in ZIKV-GBS target heterogeneous peripheral nerve antigens suggesting heterogeneity of the humoral immune response despite a common prodromal infection.