Simon Rodney
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View article: Monitoring for pneumonitis in breast cancer patients treated with trastuzumab deruxtecan: a single-centre experience
Monitoring for pneumonitis in breast cancer patients treated with trastuzumab deruxtecan: a single-centre experience Open
Background: Trastuzumab deruxtecan (T-DXd) is a highly effective treatment for human epidermal growth factor receptor 2 (HER2)-positive and HER2-low advanced breast cancer. Following two fatal pneumonitis cases within 6 months of introduci…
View article: Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship Between Potatoes and Colorectal Cancer
Evaluating the Reproducibility and Verifiability of Nutrition Research: A Case Study of Studies Assessing the Relationship Between Potatoes and Colorectal Cancer Open
Background The credibility of nutritional research is dependent on the rigor with which studies are conducted and the ability for independent assessment to be performed. Despite the importance of these, more work is needed in the field of …
View article: Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 1. Proportion of MVPs in penile cancers.
View article: Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 6. Heatmap of 6 HNSCC cell lines (in duplicate) showing the methylation of the 30 probe set HPV classifier
View article: Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 2. Primers sequences for A) HPV primers, B)analysis of CDO1 and AR gene expression and C) MSP analysis of HMX3, PPP2R5C, IRF4, FLI1.
View article: Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 2. Comparison of gene expression between PeCa and matched normal tissue for PRC2 complex members
View article: Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 4. Comparison of DMR profiles across canonical features for PeCa (green) and normal squamous epithelium (red), for three candidate epigenetically regulated genes involved in the development of penile cancer (AR &CDO1).
View article: Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary Table 1. A)Patient details for Fresh Frozen test cohort, B) Patient details for validation cohort. Supplementary Figure 1. APOBEC mutation fraction of across multiple cancer types. Supplementary Figure 2. DNA methylation. Sup…
View article: Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Purpose: Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contrib…
View article: Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 1. Patient details for A) Fresh Frozen test cohort and B) archival validation cohort
View article: Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary methods
View article: Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Methods from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary methods
View article: Supplementary Figure 5 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 5 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 5. A) Receiver Operator Curve (ROC), for the accuracy of the epigenetic lymph node prediction signature in cross validation. B) Examples of FLI1 and IRX4 immunohistochemical staining of a PeCa TMA, in samples showing e…
View article: Supplementary Figure 3 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 3 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 3. Methylation profiles of PeCa (green) and normal penile tissue (red) across canonical gene structure
View article: Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 1. Patient details for A) Fresh Frozen test cohort and B) archival validation cohort
View article: Supplementary Figure 3 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 3 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 3. Methylation profiles of PeCa (green) and normal penile tissue (red) across canonical gene structure
View article: Data from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Data from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing…
View article: Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 4 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 4. Comparison of DMR profiles across canonical features for PeCa (green) and normal squamous epithelium (red), for three candidate epigenetically regulated genes involved in the development of penile cancer (AR &CDO1).
View article: Data from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Data from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing…
View article: Supplementary Figure 5 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 5 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 5. A) Receiver Operator Curve (ROC), for the accuracy of the epigenetic lymph node prediction signature in cross validation. B) Examples of FLI1 and IRX4 immunohistochemical staining of a PeCa TMA, in samples showing e…
View article: Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 2. Comparison of gene expression between PeCa and matched normal tissue for PRC2 complex members
View article: Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 1 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 1. Proportion of MVPs in penile cancers.
View article: Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma
Supplementary Table 1 and Supplementary Figures 1 through 6 from <i>CSN1</i> Somatic Mutations in Penile Squamous Cell Carcinoma Open
Supplementary Table 1. A)Patient details for Fresh Frozen test cohort, B) Patient details for validation cohort. Supplementary Figure 1. APOBEC mutation fraction of across multiple cancer types. Supplementary Figure 2. DNA methylation. Sup…
View article: Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Data from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Purpose: Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contrib…
View article: Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Table 2 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Table 2. Primers sequences for A) HPV primers, B)analysis of CDO1 and AR gene expression and C) MSP analysis of HMX3, PPP2R5C, IRF4, FLI1.
View article: Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Supplementary Figure 6 from Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer Open
Supplementary Figure 6. Heatmap of 6 HNSCC cell lines (in duplicate) showing the methylation of the 30 probe set HPV classifier
View article: Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Open
Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) ( NCT03226886 ) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administ…
View article: Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study Open
CAPTURE (NCT03226886) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconver…
View article: Performance comparison and in-silico harmonization of commercial platforms for DNA methylome analysis by targeted bisulfite sequencing
Performance comparison and in-silico harmonization of commercial platforms for DNA methylome analysis by targeted bisulfite sequencing Open
DNA methylation is a key epigenetic modification in the regulation of cell fate and differentiation, and its analysis is gaining increasing importance in both basic and clinical research. Targeted Bisulfite Sequencing (TBS) has become the …