Simon S. Skene
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View article: Within and between sleep and cognition: associations in older community dwelling individuals
Within and between sleep and cognition: associations in older community dwelling individuals Open
Cross sectional and interventional studies have demonstrated that sleep has a significant impact on waking brain function including alertness and cognitive performance. Few studies have assessed whether spontaneous night-to-night variation…
View article: Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy Open
Objective Exenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof‐of‐concept clinical trial. Methods In thi…
View article: Emulating real-world GLP-1 efficacy in type 2 diabetes through causal learning and virtual patients
Emulating real-world GLP-1 efficacy in type 2 diabetes through causal learning and virtual patients Open
Randomized controlled trials (RCTs) remain the benchmark for assessing treatment effects but are limited to phenotypically narrow populations by design. We introduce a novel generative artificial intelligence (AI) driven emulation method t…
View article: Dietary Sources and Amounts of Flavan-3-Ols for Cardiovascular Benefit – A Meta-Analysis
Dietary Sources and Amounts of Flavan-3-Ols for Cardiovascular Benefit – A Meta-Analysis Open
View article: Methodological approaches and author-reported limitations in evaluation studies of digital health technologies (DHT): A scoping review of DHT interventions for cancer, diabetes mellitus, and cardiovascular diseases
Methodological approaches and author-reported limitations in evaluation studies of digital health technologies (DHT): A scoping review of DHT interventions for cancer, diabetes mellitus, and cardiovascular diseases Open
Digital health technology (DHT) holds the potential to improve health services, and its adoption has proliferated in recent decades owing to technological advancement. Optimal evaluation methodologies appropriate for generating quality evi…
View article: Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial
Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial Open
National Institute for Health and Care Research and Cure Parkinson's.
View article: The Perceptions of Patients, Carers and Clinicians Relating to SACT Decision‐Making in Older People With Cancer: Qualitative Findings From the Electronic Frailty Index (eFI) in Cancer Study
The Perceptions of Patients, Carers and Clinicians Relating to SACT Decision‐Making in Older People With Cancer: Qualitative Findings From the Electronic Frailty Index (eFI) in Cancer Study Open
Objective: To explore the perceptions and experiences of patients, carers and clinicians relating to treatment decision‐making in older people with cancer, and to investigate the acceptability of the eFI as a tool to influence decisions ab…
View article: The SEE‑IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: a feasibility randomised controlled trial
The SEE‑IT Trial: emergency medical services Streaming Enabled Evaluation In Trauma: a feasibility randomised controlled trial Open
This article consists of a citation of a published article describing research funded by the Health and Social Care Delivery Research programme under project number NIHR130811, and is provided as as part of the complete record of research …
View article: Diurnal variation in blood‐based biomarkers for neurodegeneration and the circadian markers melatonin and cortisol in Alzheimer's
Diurnal variation in blood‐based biomarkers for neurodegeneration and the circadian markers melatonin and cortisol in Alzheimer's Open
Background Disruption in diurnal rest‐activity rhythms is a hallmark of Alzheimer’s disease. Currently, we know little about how physiology, symptoms, and biomarkers change over the 24‐hour day in people living with Alzheimer’s disease. In…
View article: Management of inoperable malignant bowel obstruction using the 4‐step BOUNCED diet
Management of inoperable malignant bowel obstruction using the 4‐step BOUNCED diet Open
Background Malignant bowel obstruction (MBO) presents with multiple symptoms. The 4‐step BOUNCED diet educates patients to self‐manage oral intake according to symptoms. It includes clear fluids, thin liquids, purée and soft, sloppy foods,…
View article: P-tau217 and other blood biomarkers of dementia: variation with time of day
P-tau217 and other blood biomarkers of dementia: variation with time of day Open
View article: Patients’ and Clinicians’ Experiences Using a Real-Time Remote Monitoring System for Chemotherapy Symptom Management (ASyMS): Qualitative Study
Patients’ and Clinicians’ Experiences Using a Real-Time Remote Monitoring System for Chemotherapy Symptom Management (ASyMS): Qualitative Study Open
Background Patients receiving chemotherapy require ongoing symptom monitoring and management to optimize their outcomes. In recent years, digital remote monitoring interventions have emerged to provide enhanced cancer care delivery experie…
View article: Safety and procedural success of daycase-based endovascular procedures in lower extremity arteries of patients with peripheral artery disease: a systematic review and meta-analysis
Safety and procedural success of daycase-based endovascular procedures in lower extremity arteries of patients with peripheral artery disease: a systematic review and meta-analysis Open
View article: Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early‐ to Mid‐Stage Parkinson's Disease Modification Trials
Exploring Analysis Approaches for Using the Dopamine Transporter Striatal Binding Ratio in Early‐ to Mid‐Stage Parkinson's Disease Modification Trials Open
Background The dopamine transporter striatal binding ratio (DAT SBR) has been used as an outcome measure in Parkinson's disease (PD) trials of potential disease‐modifying therapies; however, both patient characteristics and analysis approa…
View article: MIRRORS ICG: Perfusion Assessment Using Indocyanine Green (ICG) Peritoneal Angiography during Robotic Interval Cytoreductive Surgery for Advanced Ovarian Cancer
MIRRORS ICG: Perfusion Assessment Using Indocyanine Green (ICG) Peritoneal Angiography during Robotic Interval Cytoreductive Surgery for Advanced Ovarian Cancer Open
Indocyanine green (ICG) is a fluorescent dye used for sentinel lymph node assessment and the assessment of perfusion in skin flaps and bowel anastomoses. ICG binds serum proteins and behaves as a macromolecule in the circulation. Tumour ti…
View article: Artificial Intelligence to Facilitate Clinical Trial Recruitment in Age-Related Macular Degeneration
Artificial Intelligence to Facilitate Clinical Trial Recruitment in Age-Related Macular Degeneration Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: MIRRORS: a prospective cohort study assessing the feasibility of robotic interval debulking surgery for advanced-stage ovarian cancer
MIRRORS: a prospective cohort study assessing the feasibility of robotic interval debulking surgery for advanced-stage ovarian cancer Open
View article: Patients’ and Clinicians’ Perceptions of the Clinical Utility of Predictive Risk Models for Chemotherapy-Related Symptom Management: Qualitative Exploration Using Focus Groups and Interviews
Patients’ and Clinicians’ Perceptions of the Clinical Utility of Predictive Risk Models for Chemotherapy-Related Symptom Management: Qualitative Exploration Using Focus Groups and Interviews Open
Background Interest in the application of predictive risk models (PRMs) in health care to identify people most likely to experience disease and treatment-related complications is increasing. In cancer care, these techniques are focused pri…
View article: Artificial intelligence to facilitate clinical trial recruitment in age-related macular degeneration
Artificial intelligence to facilitate clinical trial recruitment in age-related macular degeneration Open
Background Recent developments in artificial intelligence (AI) have positioned it to transform several stages of the clinical trial process. In this study, we explore the role of AI in clinical trial recruitment of individuals with geograp…
View article: Prognostic and predictive value of ultrasound-based estimated ankle brachial pressure index at early follow-up after endovascular revascularization of chronic limb-threatening ischaemia: a prospective, single-centre, service evaluation
Prognostic and predictive value of ultrasound-based estimated ankle brachial pressure index at early follow-up after endovascular revascularization of chronic limb-threatening ischaemia: a prospective, single-centre, service evaluation Open
European Partnership on Metrology, co-financed from European Union's Horizon Europe Research and Innovation Programme and UK Research and Innovation.
View article: Safety and Procedural Success of Daycase-Based Endovascular Procedures in Lower Extremity Arteries of Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis
Safety and Procedural Success of Daycase-Based Endovascular Procedures in Lower Extremity Arteries of Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis Open
View article: PRIORITY Trial: Results from a feasibility randomised controlled trial of a psychoeducational intervention for parents to prevent disordered eating in children and young people with type 1 diabetes
PRIORITY Trial: Results from a feasibility randomised controlled trial of a psychoeducational intervention for parents to prevent disordered eating in children and young people with type 1 diabetes Open
Aims Children and young people (CYP) with type 1 diabetes (T1D) are at increased risk of disordered eating. This study aimed to determine the feasibility and acceptability of a novel, theoretically informed, two‐session psychoeducational i…
View article: P-tau217 and other blood biomarkers of dementia: variation with time of day
P-tau217 and other blood biomarkers of dementia: variation with time of day Open
Plasma biomarkers of dementia, including phosphorylated tau (p-tau217), offer promise as tools for diagnosis, stratification for clinical trials, monitoring disease progression, and assessing the success of interventions in those living wi…
View article: Managing oral diet following a diagnosis of sub-acute malignant bowel obstruction: Results of the 4-step bounced diet feasibility study
Managing oral diet following a diagnosis of sub-acute malignant bowel obstruction: Results of the 4-step bounced diet feasibility study Open
View article: Can we improve the management of inoperable malignant bowel obstruction? Results of a feasibility study of Elemental Diet as an alternative to parenteral nutrition in patients with advanced gynaecological cancer
Can we improve the management of inoperable malignant bowel obstruction? Results of a feasibility study of Elemental Diet as an alternative to parenteral nutrition in patients with advanced gynaecological cancer Open
Purpose. Nutrition support in inoperable bowel obstruction (IBO) remains challenging. Parenteral nutrition (PN) is recommended if prognosis is > 2 months. An elemental diet (ED) is licensed for strictures in Crohn’s disease but has not bee…
View article: Patients’ and Clinicians’ Experiences Using a Real-Time Remote Monitoring System for Chemotherapy Symptom Management (ASyMS): Qualitative Study (Preprint)
Patients’ and Clinicians’ Experiences Using a Real-Time Remote Monitoring System for Chemotherapy Symptom Management (ASyMS): Qualitative Study (Preprint) Open
BACKGROUND Patients receiving chemotherapy require ongoing symptom monitoring and management to optimize their outcomes. In recent years, digital remote monitoring interventions have emerged to provide enhanced cancer care delivery experi…
View article: Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Chronic Limb-Threatening Ischaemia: A Single-Centre Retrospective Cohort Study
Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Chronic Limb-Threatening Ischaemia: A Single-Centre Retrospective Cohort Study Open
We evaluated the impact of COVID-19 restriction on the angioplasty service and outcome of chronic limb-threatening ischaemia (CLTI) patients undergoing lower-limb angioplasty in a UK secondary care setting. Consecutive patients were analys…
View article: Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Critical Limb Ischaemia: A Single-Centre Retrospective Cohort Study
Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Critical Limb Ischaemia: A Single-Centre Retrospective Cohort Study Open
We evaluated the impact of COVID-19 restriction on the angioplasty service and outcome of critical limb ischaemia (CLI) patients undergoing lower limb angioplasty in a UK secondary care setting. Consecutive patients were analysed retrospec…
View article: Patients’ and Clinicians’ Perceptions of the Clinical Utility of Predictive Risk Models for Chemotherapy-Related Symptom Management: Qualitative Exploration Using Focus Groups and Interviews (Preprint)
Patients’ and Clinicians’ Perceptions of the Clinical Utility of Predictive Risk Models for Chemotherapy-Related Symptom Management: Qualitative Exploration Using Focus Groups and Interviews (Preprint) Open
BACKGROUND Interest in the application of predictive risk models (PRMs) in health care to identify people most likely to experience disease and treatment-related complications is increasing. In cancer care, these techniques are focused pr…
View article: COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2
COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2 Open
Grants and gifts from the Medical Research Council UKRI (MC_PC_19076), the National Institute for Health Research/Vaccine Task Force, Partners of Citadel and Citadel Securities, Sir Joseph Hotung Charitable Settlement, Jon Moulton Charity …