Simon Spindler
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View article: Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT
Synchrotron radiation based analyzer-free dual-phase dark-field lung imaging approach for radiography and CT Open
Lung diseases such as chronic obstructive pulmonary disease are a major health burden to society for which early detection plays a crucial role for treatment success. For detection, as well as diagnosis and serial evaluation, imaging plays…
View article: Simultaneous signal optimization of refraction and attenuation in x‐ray grating interferometry: A case study for breast imaging
Simultaneous signal optimization of refraction and attenuation in x‐ray grating interferometry: A case study for breast imaging Open
Background X‐ray grating interferometry has emerged as a promising imaging technique for breast computed tomography (BCT), offering complementary contrast from refraction beyond conventional absorption imaging. Although it provides higher …
View article: Simulation study of an X-ray diffraction beamlet array for dark-field chest CT
Simulation study of an X-ray diffraction beamlet array for dark-field chest CT Open
We introduce diffraction beamlet arrays (DBAs), a technique that overcomes the limitations of conventional X-ray grating interferometry, especially when combined with computed tomography (CT) applications. Traditional interferometry system…
View article: Quantifying grating defects in X-ray Talbot-Lau interferometry through a comparative study of two fabrication techniques
Quantifying grating defects in X-ray Talbot-Lau interferometry through a comparative study of two fabrication techniques Open
The performance of an X-ray grating interferometry system depends on the geometry and quality of the gratings. Fabrication of micrometer-pitch high-aspect-ratio gold gratings, which are essential for measuring small refraction angles at hi…
View article: Simulation framework for X-ray grating interferometry optimization
Simulation framework for X-ray grating interferometry optimization Open
Wave-front propagation simulations have been a tool to design and optimize X-ray interferometry devices. The often used plane wave approaches, however, lack the angular resolution to describe effects like system imperfections or inhomogene…
View article: Optimization of Dark-Field CT for Lung Imaging
Optimization of Dark-Field CT for Lung Imaging Open
Background: X-ray grating-based dark-field imaging can sense the small angle scattering caused by an object's micro-structure. This technique is sensitive to lung's porous alveoli and is able to detect lung disease at an early stage. Up to…
View article: Data-Driven Gradient Regularization for Quasi-Newton Optimization in Iterative Grating Interferometry CT Reconstruction
Data-Driven Gradient Regularization for Quasi-Newton Optimization in Iterative Grating Interferometry CT Reconstruction Open
Grating interferometry CT (GI-CT) is a promising technology that could play an important role in future breast cancer imaging. Thanks to its sensitivity to refraction and small-angle scattering, GI-CT could augment the diagnostic content o…
View article: Increased dose efficiency of breast CT with grating interferometry
Increased dose efficiency of breast CT with grating interferometry Open
Refraction-based x-ray imaging can overcome the fundamental contrast limit of computed tomography (CT), particularly in soft tissue, but so far has been constrained to high-dose ex vivo applications or required highly coherent x-ray source…
View article: Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction
Towards clinical-dose grating interferometry breast CT with fused intensity-based iterative reconstruction Open
X-ray grating interferometry CT (GI-CT) is an emerging imaging modality which provides three complementary contrasts that could increase the diagnostic content of clinical breast CT: absorption, phase, and dark-field. Yet, reconstructing t…
View article: Refraction beats attenuation in breast CT
Refraction beats attenuation in breast CT Open
For a century, clinical X-ray imaging has visualised only the attenuation properties of tissue, which fundamentally limits the contrast, particularly in soft tissues like the breast. Imaging based on refraction can overcome this limitation…
View article: Intensity-based iterative reconstruction for helical grating interferometry breast CT with static grating configuration
Intensity-based iterative reconstruction for helical grating interferometry breast CT with static grating configuration Open
Grating interferometry breast computed tomography (GI-BCT) has the potential to provide enhanced soft tissue contrast and to improve visualization of cancerous lesions for breast imaging. However, with a conventional scanning protocol, a G…