Simon Ströbel
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Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model Open
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe liver disease characterized by lipid accumulation, inflammation and fibrosis. The development of MASH therapies has been hindered by the lack of human translational models…
A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates Open
Non-alcoholic steatohepatitis (NASH) is a progressive and severe liver disease, characterized by lipid accumulation, inflammation, and downstream fibrosis. Despite its increasing prevalence, there is no approved treatment yet available for…
A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates Open
Non-alcoholic steatohepatitis (NASH) is a progressive and severe liver disease, characterized by lipid accumulation, inflammation, and downstream fibrosis. Despite its increasing prevalence, there is no approved treatment yet available for…
User-oriented systematic of control concepts for fluidmechatronic servo drives Open
This paper aims to show that controlled hydraulic drives, when properly considered and approached, are a technology that allows for a systematic and safe system design with regard to performance and energy efficiency.Controlled hydraulic d…
View article: Skin Filling and Firming Activity of a Hyaluronic Acid Inducing Synthetic Tripeptide
Skin Filling and Firming Activity of a Hyaluronic Acid Inducing Synthetic Tripeptide Open
Aging of skin manifests in loss of volume and firming due to degradation of extracellular matrix components such as collagen and hyaluronic acid leading to wrinkling and sagging. To counteract loss of facial volume and regain firmness, fil…
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury Open
Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in dru…