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View article: RewriteLM: An Instruction-Tuned Large Language Model for Text Rewriting
RewriteLM: An Instruction-Tuned Large Language Model for Text Rewriting Open
Large Language Models (LLMs) have demonstrated impressive capabilities in creative tasks such as storytelling and E-mail generation. However, as LLMs are primarily trained on final text results rather than intermediate revisions, it might …
View article: RewriteLM: An Instruction-Tuned Large Language Model for Text Rewriting
RewriteLM: An Instruction-Tuned Large Language Model for Text Rewriting Open
Large Language Models (LLMs) have demonstrated impressive capabilities in creative tasks such as storytelling and E-mail generation. However, as LLMs are primarily trained on final text results rather than intermediate revisions, it might …
View article: GLaM: Efficient Scaling of Language Models with Mixture-of-Experts
GLaM: Efficient Scaling of Language Models with Mixture-of-Experts Open
Scaling language models with more data, compute and parameters has driven significant progress in natural language processing. For example, thanks to scaling, GPT-3 was able to achieve strong results on in-context learning tasks. However, …
View article: Structure–activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting <i>Mtb</i>-FtsZ as antitubercular agents
Structure–activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting <i>Mtb</i>-FtsZ as antitubercular agents Open
Filamenting temperature sensitive protein Z (FtsZ) is an essential bacterial cell division protein and a promising target for the development of new antibacterial therapeutics.
View article: SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins
SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins Open
View article: Contribution of diacylglycerol lipase &beta; to pain after surgery
Contribution of diacylglycerol lipase β to pain after surgery Open
DAGLβ is not the principal enzyme that controls 2-AG derived AA and PGE2 production after surgery, and inhibitors targeting this enzyme are unlikely to be efficacious analgesics superior to those already approved to treat acute …
View article: Contribution of diacylglycerol lipase β to pain after surgery
Contribution of diacylglycerol lipase β to pain after surgery Open
Jennifer Luk,1 Yong Lu,1 Amanda Ackermann,1 Xiaoxue Peng,1 Diane Bogdan,1 Michelino Puopolo,1 David E Komatsu,2 Simon Tong,3 Iwao Ojima,3,4 Mario J Rebecchi,1 Martin Kaczocha1,4 1Department of Anesthesiology, 2Department of Orthopedics, 3D…
View article: The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites
The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites Open
Human FABP5 and FABP7 are intracellular endocannabinoid transporters. SBFI-26 is an α-truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effe…
View article: Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms
Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms Open
Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of…
View article: Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ
Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ Open