Simon U. Jaeger
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View article: Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters
Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters Open
Background: Membrane transport proteins are critical determinants of systemic and intracellular drug levels, thereby contributing substantially to drug response and/or adverse drug reactions. Therefore, the U.S. Food and Drug Administratio…
View article: Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults
Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults Open
Together, a single application of CoVac-1 elicits long-lived and broad SARS-CoV-2-specific T cell immunity, which further supports the current evaluation of our T cell activator in patients with congenital or acquired B-cell defects.
View article: Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults
Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults Open
Background T cell immunity is key for the control of viral infections including SARS-CoV-2, in particular with regard to immune memory and protection against arising genetic variants. Method We recently evaluated a peptide-based SARS-CoV-2…
View article: A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy
A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy Open
Background and study aims Indeterminate biliary strictures represent a major challenge in clinical diagnostics. Diagnostic yield of radiological, endoscopic imaging and histopathological diagnosis is insufficient. The cryobiopsy technique …
View article: Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving?
Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving? Open
Background Mobility is defined as the ability to independently move around the environment and is a key contributor to quality of life, especially in older age. The aim of this study was to evaluate the use of mobility as a decisive outcom…
View article: The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study Open
Aims Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. Methods Cases o…
View article: The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center
The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center Open
Background: Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods: In a cohort of 121 kidney …
View article: Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis
Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis Open
Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes a common problem in patients with Crohn’s disease (CD). While fibrosis seems to require inflammation as a prerequisite it is unclear whether the…
View article: Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease Open
A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn's disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intesti…
View article: Supplementary Material for: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis
Supplementary Material for: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis Open
Background: Ulcerative proctitis may often be managed with topical salicylates or steroids alone, but in some patients, symptoms are persistent and severe. We analyzed the efficacy of tacrolimus suppositories in patients who had proven ref…
View article: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis
Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis Open
Background: Ulcerative proctitis may often be managed with topical salicylates or steroids alone, but in some patients, symptoms are persistent and severe. We analyzed the efficacy of tacrolimus suppositories in patients who had proven ref…