Simon U. Jaeger
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View article: Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters
Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters Open
Background: Membrane transport proteins are critical determinants of systemic and intracellular drug levels, thereby contributing substantially to drug response and/or adverse drug reactions. Therefore, the U.S. Food and Drug Administratio…
View article: Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults
Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults Open
Together, a single application of CoVac-1 elicits long-lived and broad SARS-CoV-2-specific T cell immunity, which further supports the current evaluation of our T cell activator in patients with congenital or acquired B-cell defects.
View article: Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency
Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency Open
T-cell immunity is central for control of COVID-19, particularly in patients incapable of mounting antibody responses. CoVac-1 is a peptide-based T-cell activator composed of SARS-CoV-2 epitopes with documented favorable safety profile and…
View article: Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults
Long-term efficacy of the peptide-based COVID-19 T cell activator CoVac-1 in healthy adults Open
Background T cell immunity is key for the control of viral infections including SARS-CoV-2, in particular with regard to immune memory and protection against arising genetic variants. Method We recently evaluated a peptide-based SARS-CoV-2…
View article: The value of walking: a systematic review on mobility and healthcare costs
The value of walking: a systematic review on mobility and healthcare costs Open
Background The ability to walk is an important indicator of general health and mobility deficits have wide-ranging economic implications. We undertook a systematic review to elucidate the impact of walking parameters on health care costs. …
View article: A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy
A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy Open
Background and study aims Indeterminate biliary strictures represent a major challenge in clinical diagnostics. Diagnostic yield of radiological, endoscopic imaging and histopathological diagnosis is insufficient. The cryobiopsy technique …
View article: Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving?
Mobility endpoints in marketing authorisation of drugs: what gets the European medicines agency moving? Open
Background Mobility is defined as the ability to independently move around the environment and is a key contributor to quality of life, especially in older age. The aim of this study was to evaluate the use of mobility as a decisive outcom…
View article: The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study
The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study Open
Aims Older patients in particular suffer from adverse drug reactions (ADR) when presenting in the emergency department. We aimed to characterise the phenotype of those ADRs, to be able to recognise an ADR in older patients. Methods Cases o…
View article: The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center
The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center Open
Background: Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods: In a cohort of 121 kidney …
View article: Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease
Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease Open
A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn's disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intesti…
View article: Supplementary Material for: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis
Supplementary Material for: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis Open
Background: Ulcerative proctitis may often be managed with topical salicylates or steroids alone, but in some patients, symptoms are persistent and severe. We analyzed the efficacy of tacrolimus suppositories in patients who had proven ref…
View article: Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis
Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis Open
Background: Ulcerative proctitis may often be managed with topical salicylates or steroids alone, but in some patients, symptoms are persistent and severe. We analyzed the efficacy of tacrolimus suppositories in patients who had proven ref…