Simon W. Rabkin
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View article: Assessing and Managing Social Isolation and Loneliness by Clinicians in Clinical Cardiovascular Practice
Assessing and Managing Social Isolation and Loneliness by Clinicians in Clinical Cardiovascular Practice Open
View article: Cellular and Molecular Mechanisms Explaining the Link Between Inflammatory Bowel Disease and Heart Failure
Cellular and Molecular Mechanisms Explaining the Link Between Inflammatory Bowel Disease and Heart Failure Open
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is increasingly recognized as a systemic condition with cardiovascular implications. Among these, heart failure has emerged as a significant complicatio…
View article: Rapid loss of consciousness in cattle following nonstun slaughter: evidence from a systematic review
Rapid loss of consciousness in cattle following nonstun slaughter: evidence from a systematic review Open
Background Accepting that it is ethical for meat to be consumed as food, then, in any context, religious or secular, it is indefensible for animals to be subjected to undue pain. Animal slaughter must therefore be predicated on the minimiz…
View article: Epicardial Fat in Heart Failure with Preserved Ejection Fraction Compared with Reduced Ejection Fraction
Epicardial Fat in Heart Failure with Preserved Ejection Fraction Compared with Reduced Ejection Fraction Open
Background: The role of epicardial adipose tissue (EAT) in heart failure with preserved ejection fraction (HFpEF) remains to be defined. Methods: A consecutive series of outpatients with chronic heart failure—heart failure with reduced eje…
View article: The QT interval in Parkinson′s disease: a systematic review
The QT interval in Parkinson′s disease: a systematic review Open
BACKGROUND: PD (PD) is associated with a twofold increase in the risk of death especially sudden death. A predisposing factor for cardiac sudden death is prolongation of the QT interval. This study evaluated the potential association betwe…
View article: Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Ameliorate Heart Failure through Reductions in Oxidative Stress: A Systematic Review and Meta-Analysis
Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Ameliorate Heart Failure through Reductions in Oxidative Stress: A Systematic Review and Meta-Analysis Open
The objectives of this study were to explore the role that eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) plays in heart failure (HF), highlighting the potential connection to oxidative stress pathways. Following PRISMA guid…
View article: Artificial intelligence streamlines diagnosis and assessment of prognosis in Brugada syndrome: a systematic review and meta-analysis
Artificial intelligence streamlines diagnosis and assessment of prognosis in Brugada syndrome: a systematic review and meta-analysis Open
Aim: The objective of this systematic review and meta-analysis was to determine the diagnostic and prognostic utility of artificial intelligence/machine learning (AI/ML) algorithms in Brugada Syndrome (BrS). Methods: A systematic review an…
View article: Searching for the Best Machine Learning Algorithm for the Detection of Left Ventricular Hypertrophy from the ECG: A Review
Searching for the Best Machine Learning Algorithm for the Detection of Left Ventricular Hypertrophy from the ECG: A Review Open
Background: Left ventricular hypertrophy (LVH) is a powerful predictor of future cardiovascular events. Objectives: The objectives of this study were to conduct a systematic review of machine learning (ML) algorithms for the identification…
View article: The Case to Discard Hospital Mission Statements and Replace It with A Statement of Goals
The Case to Discard Hospital Mission Statements and Replace It with A Statement of Goals Open
Background: Hospitals and healthcare institutions spend a considerable amount of time and capital on constructing an appropriate mission statement for themselves. Methods: A review of the purpose of mission statements and the statements ma…
View article: Relationship between Alzheimer dementia and <scp>QT</scp> interval: A meta‐analysis
Relationship between Alzheimer dementia and <span>QT</span> interval: A meta‐analysis Open
While the link between aging and mortality from dementia is widely appreciated, the mechanism is not clear. The objective of this study was to determine whether there is a direct relationship between Alzheimer dementia (AD) and the QT inte…
View article: Estimating Left Ventricular Mass from the Electrocardiogram across the Spectrum of LV Mass from Normal to Increased LV Mass in an Older Age Group
Estimating Left Ventricular Mass from the Electrocardiogram across the Spectrum of LV Mass from Normal to Increased LV Mass in an Older Age Group Open
Objectives. To examine the relationship of QRS voltages and left ventricular (LV) mass across the spectrum of individuals with different LV mass. Methods. Twenty QRS voltage measurements or combinations were determined in a consecutive ser…
View article: Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction Open
This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be…
View article: Identifying Premature Ventricular Complexes from Outflow Tracts Based on PVC Configuration: A Machine Learning Approach
Identifying Premature Ventricular Complexes from Outflow Tracts Based on PVC Configuration: A Machine Learning Approach Open
Background: Current inferences about the site of origin (SOO) of premature ventricular complexes (PVC) from the surface ECG have not been subjected to newer data analytic techniques that identify signals that are not recognized by visual i…
View article: Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis
Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis Open
Background: The main objective of this study was to determine whether myocardial strain and myocardial work are altered in hypertension and whether the strain is independent of hypertension-induced left ventricular hypertrophy. Methods: Tw…
View article: Heart Disease and Stroke
Heart Disease and Stroke Open
Dear Readers, I'm pleased to introduce a special issue on "Heart disease and stroke," from a group of distinguished editors and productive authors from around the globe. It is well known that ischemic heart disease (IHD) is a leading cause…
View article: Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain
Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain Open
Aim: Hypertension (HTN) is a major cause of heart failure but the precise pathways by which HTN leads to heart failure are not resolved. Newer echocardiographic techniques permit assessment of myocardial contraction in different orientatio…
View article: Differences in circadian variation in QT interval of the ECG in women compared to men.
Differences in circadian variation in QT interval of the ECG in women compared to men. Open
The time of the day that the QT interval is assessed should be considered. The QT heart rate relationship is different in women than in men especially at night. QT interval variability is greater at night especially in men. There are diffe…
View article: Collagen type IV as the link between arterial stiffness and dementia.
Collagen type IV as the link between arterial stiffness and dementia. Open
Arterial stiffness has been linked to impaired cognitive function and dementia but the reason for the association is uncertain. This review proposes that collagen type IV is a critical factor linking arterial stiffness and dementia. Severa…
View article: Comparison of Unsupervised Machine Learning Approaches for Cluster Analysis to Define Subgroups of Heart Failure with Preserved Ejection Fraction with Different Outcomes
Comparison of Unsupervised Machine Learning Approaches for Cluster Analysis to Define Subgroups of Heart Failure with Preserved Ejection Fraction with Different Outcomes Open
Heart failure with preserved ejection (HFpEF) is a heterogenous condition affecting nearly half of all patients with heart failure (HF). Artificial intelligence methodologies can be useful to identify patient subclassifications with import…
View article: Hypocalcemia-Induced QT Interval Prolongation
Hypocalcemia-Induced QT Interval Prolongation Open
An 87-year-old man with a history of transcatheter aortic valve replacement, pulmonary hypertension, diastolic dysfunction with preserved systolic function, and myelofibrosis had a 12-lead ECG showed a prolonged QT interval of 508 ms with …
View article: Evaluating the adverse outcome of subtypes of heart failure with preserved ejection fraction defined by machine learning: a systematic review focused on defining high risk phenogroups
Evaluating the adverse outcome of subtypes of heart failure with preserved ejection fraction defined by machine learning: a systematic review focused on defining high risk phenogroups Open
The ability to distinguish clinically meaningful subtypes of heart failure with preserved ejection fraction (HFpEF) has recently been examined by machine learning techniques but studies appear to have produced discordant results. The objec…
View article: The Fundamental Basis of Palpitations: A Neurocardiology Approach
The Fundamental Basis of Palpitations: A Neurocardiology Approach Open
Background and Objective: Palpitations are a common symptom that may indicate cardiac arrhythmias, be a somatic complaint in anxiety disorders, and can be present in patients without either condition. The objective of this review was to ex…
View article: Overcoming Obstacles to Develop High-Performance Teams Involving Physician in Health Care Organizations
Overcoming Obstacles to Develop High-Performance Teams Involving Physician in Health Care Organizations Open
Many health care organizations struggle and often do not succeed to be high-performance organizations that are not only efficient and effective but also enjoyable places to work. This review focuses on the physician and organizational role…
View article: Greenhouse Gas Emissions an Index of Global Warming is not Associated with Ischemic Heart Disease Mortality
Greenhouse Gas Emissions an Index of Global Warming is not Associated with Ischemic Heart Disease Mortality Open
Objective: The objective of this study was to examine the relationship between greenhouse gas (GHG) emissions and ischemic heart disease (IHD) and for comparison chronic lower respiratory tract disease (RESP) mortality, between different c…
View article: The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation
The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation Open
A short QT interval has been difficult to define, and there is debate whether it exists outside of an extremely small group of individuals with inherited channelopathies and whether it predicts cardiac arrhythmias. The objective was to ide…
View article: Blood Pressure Variability
Blood Pressure Variability Open
View article: Physician engagement: the Vancouver Medical Staff Association engagement charter
Physician engagement: the Vancouver Medical Staff Association engagement charter Open
View article: Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children Open
Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension in adults and children. This year, the adult and pediatric guidelines are combined in one doc…
View article: A patient‐specific approach to assessing blood pressure management in patients with hypertension and coronary artery disease
A patient‐specific approach to assessing blood pressure management in patients with hypertension and coronary artery disease Open
The objective was to improve the management of patients with hypertension ( HTN ) and coronary artery disease ( CAD ), utilizing a model which integrates 3 determinants of coronary blood flow ( CBF )— CAD severity, diastolic blood pressure…
View article: Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate
Value of the New Spline QTc Formula in Adjusting for Pacing-Induced Changes in Heart Rate Open
Aims . To determine whether a new QTc calculation based on a Spline fit model derived and validated from a large population remained stable in the same individual across a range of heart rates (HRs). Second, to determine whether this formu…