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View article: Impact of interdisciplinary tumor boards (ITB) and personalized treatment on survival outcomes in metastatic castration-resistant prostate cancer
Impact of interdisciplinary tumor boards (ITB) and personalized treatment on survival outcomes in metastatic castration-resistant prostate cancer Open
Purpose Interdisciplinary tumor boards (ITB) are essential in optimizing treatment recommendations for metastatic castration-resistant prostate cancer (mCRPC) by incorporating oncology guidelines, clinical trials, and patient-specific fact…
View article: PD-L1 Expression in High-Risk Non-Muscle-Invasive Bladder Cancer Is Influenced by Intravesical Bacillus Calmette–Guérin (BCG) Therapy
PD-L1 Expression in High-Risk Non-Muscle-Invasive Bladder Cancer Is Influenced by Intravesical Bacillus Calmette–Guérin (BCG) Therapy Open
In the expanding landscape of immune checkpoint inhibitors (CPI) in high-risk (HR) non-muscle-invasive bladder cancer (NMIBC), the role of programmed death ligand 1 (PD-L1) as prognostic and predictive is increasingly significant. However,…
View article: Differentiation of bladder cancer with water flow elastography (WaFE)
Differentiation of bladder cancer with water flow elastography (WaFE) Open
Cancer affects the mechanical properties of tissue. Therefore, elastography techniques can be used to differentiate cancerous from healthy tissue. Due to probe size and restricted handling, most elastography techniques are not applicable i…
View article: 93P A new platform for fast-track molecular stratification of endometrial carcinomas enabling timely treatment decisions in precision oncology
93P A new platform for fast-track molecular stratification of endometrial carcinomas enabling timely treatment decisions in precision oncology Open
Endometrial carcinomas (EC) are the most common gynecological cancer in the developed world. The original histopathology-based classification has been supplemented in the recent years by a molecular classification, based on the analysis of…
View article: Stress Urinary Incontinence: An Unsolved Clinical Challenge
Stress Urinary Incontinence: An Unsolved Clinical Challenge Open
Stress urinary incontinence is still a frequent problem for women and men, which leads to pronounced impairment of the quality of life and withdrawal from the social environment. Modern diagnostics and therapy improved the situation for in…
View article: A Protocol for Organoids from the Urine of Bladder Cancer Patients
A Protocol for Organoids from the Urine of Bladder Cancer Patients Open
This study investigates the feasibility of establishing urine-derived tumor organoids from bladder cancer (BC) patients as an alternative to tissue-derived organoids. BC is one of the most common cancers worldwide and current diagnostic me…
View article: Effects of Scaffolds on Urine- and Urothelial Carcinoma Tissue-Derived Organoids from Bladder Cancer Patients
Effects of Scaffolds on Urine- and Urothelial Carcinoma Tissue-Derived Organoids from Bladder Cancer Patients Open
Organoids are three-dimensional constructs generated by placing cells in scaffolds to facilitate the growth of cultures with cell–cell and cell–matrix interactions close to the in vivo situation. Organoids may contain different types of ce…
View article: Differential Expression and Clinical Relevance of C-X-C Motif Chemokine Receptor 4 (CXCR4) in Renal Cell Carcinomas, Benign Renal Tumors, and Metastases
Differential Expression and Clinical Relevance of C-X-C Motif Chemokine Receptor 4 (CXCR4) in Renal Cell Carcinomas, Benign Renal Tumors, and Metastases Open
C-X-C Motif Chemokine Receptor 4 (CXCR4) is part of the human chemokine system and involved in progression and metastasis in renal cell carcinoma (RCC). However, the role of CXCR4 protein expression in RCC remains controversial. In particu…
View article: Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer
Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer Open
Molecular stratification can improve the management of advanced cancers, but requires relevant tumor samples. Metastatic urothelial carcinoma (mUC) is poised to benefit given a recent expansion of treatment options and its high genomic het…
View article: Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review
Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review Open
Bone health in prostate cancer patients represents a prerequisite for acceptable quality of life and optimal outcome of this disease. The major threat for bone health in prostate cancer displays cancer treatment induced bone loss as well a…
View article: MP41-03 EXPRESSION OF SOMATOSTATIN RECEPTORS IN PATIENTS WITH ADVANCED BLADDER CANCER IS AN INDICATOR FOR FAVORABLE OUTCOME
MP41-03 EXPRESSION OF SOMATOSTATIN RECEPTORS IN PATIENTS WITH ADVANCED BLADDER CANCER IS AN INDICATOR FOR FAVORABLE OUTCOME Open
You have accessJournal of UrologyBladder Cancer: Invasive III1 Apr 2018MP41-03 EXPRESSION OF SOMATOSTATIN RECEPTORS IN PATIENTS WITH ADVANCED BLADDER CANCER IS AN INDICATOR FOR FAVORABLE OUTCOME Moritz Maas, Jörg Hennenlotter, Lisa Rudolph…
View article: Expression of tumour progression‐associated genes in circulating tumour cells of patients at different stages of prostate cancer
Expression of tumour progression‐associated genes in circulating tumour cells of patients at different stages of prostate cancer Open
Objective To evaluate the presence of circulating tumour cells ( CTC s) at different stages of prostate cancer using the AdnaTest ® ProstateCancerDetect kit (Qiagen). Moreover, we aimed to assess the expression of transcripts that are spec…
View article: Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?
Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder? Open
Objectives . To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). Patients and Methods . Th…
View article: Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer
Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer Open
Bone metastases have a major impact on quality of life and survival of patients with advanced prostate cancer. In the last decade, the development and approval of substances inhibiting the vicious cycle of bone metastases have enabled the …
View article: A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and “pan-leukemia” antigens
A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and “pan-leukemia” antigens Open
Hematological malignancies (HM) are highly amenable targets for immunotherapeutic intervention and may be effectively treated by antigen-specific T-cell based treatment. Recent studies demonstrate that physiologically occurring anti-cancer…
View article: The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy
The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell–based immunotherapy Open
Key Points Direct analysis of the HLA-presented peptidome identifies a distinct antigenic signature in MM. T-cell responses for these antigens are detectable exclusively in MM patients and can be induced in vitro in response-naive patients.