Simon Wittmann
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A Bright Spiropyran-Based Zinc Sensor for Live-Cell Imaging Open
Pools of labile bound zinc ions are essential for signal transduction in the human body. At the cellular level, such pools occur in the cytosol, discrete organelles, and secretory vesicles. These zinc-containing vesicles are found in disti…
Four new bright members of the ZinPyr zinc fluorescence sensor family for live cell imaging Open
As the second most abundant trace element, zinc plays numerous roles in the human body. Not only tightly bound as structural component and co-factor of more than 3000 proteins, but also as labile bound zinc, so-called mobile Zn (mZn). This…
Stochastic intrinsic gradient flows on the Wasserstein space Open
We construct stochastic gradient flows on the $2$-Wasserstein space $\mathcal P_2$ over $\mathbb R^d$ for energy functionals of the type $W_F(ρd x)=\int_{\mathbb R^d}F(x,ρ(x))d x$. The functions $F$ and $\partial_2 F$ are assumed to be loc…
Four new bright members of the ZinPyr zinc fluorescence sensor family for live cell imaging Open
As second most abundant trace element, zinc plays numerous roles in the human body. Not only as structural component and co-factor of more than 3,000 proteins, but also as so-called mobile Zn, mZn – pools of labile bound zinc ions. This mZ…
Markov Processes and Stochastic Extrinsic Derivative Flows on the Space of Absolutely Continuous Measures Open
Let $E$ be the class of finite (resp. probability) measures absolutely continuous with respect to a $σ$-finite Radon measure on a Polish space. We present a criterion on the quasi-regularity of Dirichlet forms on $E$ in terms of upper boun…
Mosco convergence of gradient forms with non-convex potentials II Open
This article provides a scaling limit for a family of skew interacting Brownian motions in the context of mesoscopic interface models. Let $d\in\mathbb N$, $y_1,\dots,y_M\in\mathbb R$ and $f\in C_b(\mathbb R)$ be fixed. For each $N\in\math…
Diffusion Processes on $p$-Wasserstein Space over Banach Space Open
To study diffusion processes on the p-Wasserstein space $\mathscr P_p$ for $p\in [1,\infty)$ over a separable, reflexive Banach space $X$, we present a criterion on the quasi-regularity of Dirichlet forms in $L^2(\mathscr P_p,Λ)$ for a ref…
Heme Oxygenase-1 and Its Role in Colorectal Cancer Open
Heme oxygenase-1 (HO-1) is an enzyme located at the endoplasmic reticulum, which is responsible for the degradation of cellular heme into ferrous iron, carbon monoxide and biliverdin-IXa. In addition to this main function, the enzyme is in…
View article: Supplementary Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner
Supplementary Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner Open
contains supplementary figures and tables
View article: Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner
Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner Open
Colorectal cancer is one of the most frequent tumor entities, with an increasing incidence and mortality in younger adults in Europe and the United States. Five-year survival rates for advanced colorectal cancer are still low, highlighting…
View article: Supplementary Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner
Supplementary Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner Open
contains supplementary figures and tables
View article: Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner
Data from The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner Open
Colorectal cancer is one of the most frequent tumor entities, with an increasing incidence and mortality in younger adults in Europe and the United States. Five-year survival rates for advanced colorectal cancer are still low, highlighting…
Mosco convergence of gradient forms with non-convex interaction potential Open
This article provides a new approach to address Mosco convergence of gradient-type Dirichlet forms, $\mathcal E^N$ on $L^2(E,μ_N)$ for $N\in\mathbb N$, in the framework of converging Hilbert spaces by K.~Kuwae and T.~Shioya. The basic assu…
Targeting Altered Energy Metabolism in Colorectal Cancer: Oncogenic Reprogramming, the Central Role of the TCA Cycle and Therapeutic Opportunities Open
Colorectal cancer (CRC) is among the most frequent cancer entities worldwide. Multiple factors are causally associated with CRC development, such as genetic and epigenetic alterations, inflammatory bowel disease, lifestyle and dietary fact…