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View article: Probing the activity of cysteine cathepsins in inflammatory bowel diseases
Probing the activity of cysteine cathepsins in inflammatory bowel diseases Open
Cathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associ…
View article: “Breaking Bread” with innovation: the challenge of product differentiation through alternative flours, fermentation, and traceability systems
“Breaking Bread” with innovation: the challenge of product differentiation through alternative flours, fermentation, and traceability systems Open
The growing demand for more sustainable and healthier foods has stimulated innovation in the food sector, particularly in the bakery industry. However, market differentiation for products such as sliced bread is limited by consumers' marke…
View article: Structure-guided allosteric modulation of the delta opioid receptor
Structure-guided allosteric modulation of the delta opioid receptor Open
Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target …
View article: Probing the activity of cysteine cathepsins in inflammatory bowel diseases
Probing the activity of cysteine cathepsins in inflammatory bowel diseases Open
Cathepsin S is a cysteine protease that has been implicated in inflammatory bowel diseases (IBD) for its ability to promote visceral pain. Given its pro-inflammatory roles, we hypothesized that cathepsin S would drive other symptoms associ…
View article: Neural control of goblet cells in the gastrointestinal tract
Neural control of goblet cells in the gastrointestinal tract Open
The mucus layer is an essential physical barrier that protects and lubricates mucosal surfaces in the body. The semipermeable nature of the mucus layer limits bacterial interactions with the epithelium while allowing nutrient absorption. G…
View article: Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia
Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia Open
This upload is associated with the software, Gut Analysis Toolbox (GAT). If you use it please cite: Sorensen et al. Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons. J Cell Sci 2024; jcs.261950. doi: https://doi.or…
View article: Isolation and characterization from raw milk of Enterocin B-producing Enterococcus faecium: A potential dairy bio-preservative agent
Isolation and characterization from raw milk of Enterocin B-producing Enterococcus faecium: A potential dairy bio-preservative agent Open
Six Enterococcus faecium strains from raw milk and ripened cheeses showed an effect in impairing L. monocytogenes cell growth. One of the strains, i.e. the RM12, was selected based on its cell-free supernatant (CFS) antilisterial activity …
View article: Asengeprast, a Novel G-Protein Coupled Receptor 68 Antagonist, Reverses Clinically Relevant Inflammatory and Fibrotic Pathways in Chronic Kidney Disease
Asengeprast, a Novel G-Protein Coupled Receptor 68 Antagonist, Reverses Clinically Relevant Inflammatory and Fibrotic Pathways in Chronic Kidney Disease Open
Limiting progressive fibrosis in chronic kidney disease (CKD) is an ongoing therapeutic challenge that requires effective and safe inhibition of a broad inflammatory cell milieu that leads to irreversible organ damage. Asengeprast, an anti…
View article: Highly neurogenic glia from human and mouse myenteric ganglia generate functional neurons following culture and transplantation into the gut
Highly neurogenic glia from human and mouse myenteric ganglia generate functional neurons following culture and transplantation into the gut Open
Enteric neural stem cell (ENSC) therapy offers great promise for neurointestinal diseases; however, current isolation methods yield insufficient neurons for regenerative applications. Multiomic profiling of enteric glial cells (EGCs) sugge…
View article: Gut Analysis Toolbox – automating quantitative analysis of enteric neurons
Gut Analysis Toolbox – automating quantitative analysis of enteric neurons Open
The enteric nervous system (ENS) consists of an extensive network of neurons and glial cells embedded within the wall of the gastrointestinal (GI) tract. Alterations in neuronal distribution and function are strongly associated with GI dys…
View article: Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit
Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit Open
Background Gut dysmotility is common after ischemic stroke, but the mechanism underlying this response is unknown. Under homeostasis, gut motility is regulated by the neurons of the enteric nervous system that control contractile/relaxatio…
View article: Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons
Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons Open
The enteric nervous system (ENS) plays an important role in coordinating gut function. The ENS consists of an extensive network of neurons and glial cells within the wall of the gastrointestinal tract. Alterations in neuronal distribution,…
View article: TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility Open
Background Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Re…
View article: The impact of COVID-19 on the demand of arthroplasty
The impact of COVID-19 on the demand of arthroplasty Open
Background Nowadays healthcare systems are affected both by a growing demand for prosthetic surgery, and by an increase of patients’ migration who are seeking a place of care more suited to their needs. This study aims to evaluate the impa…
View article: Identifying the Drivers of Inter-Regional Patients’ Mobility: An Analysis on Hospital Beds Endowment
Identifying the Drivers of Inter-Regional Patients’ Mobility: An Analysis on Hospital Beds Endowment Open
Background: In a Beveridgean decentralized healthcare system, like the Italian one, where regions are responsible for their own health planning and financing, the analysis of patients’ mobility appears very interesting as it has economic a…
View article: Identifying the Drivers of Inter-Regional Patients’ Migration: An analysis on Hospital Beds Endowment
Identifying the Drivers of Inter-Regional Patients’ Migration: An analysis on Hospital Beds Endowment Open
Background: In a Beveridgean decentralized healthcare system, like the Italian one, where regions are responsible for their own health planning and financing, the analysis of patients’ migration appears very interesting as it has economic …
View article: Assessment of the regional healthcare services' resilience during the COVID-19 pandemic: the Italian model
Assessment of the regional healthcare services' resilience during the COVID-19 pandemic: the Italian model Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: Are hospital beds endowment a driver of patients' migration?
Are hospital beds endowment a driver of patients' migration? Open
Background and Objective: In a decentralized healthcare system like the Italian,
\nwhere regions are in a potentially competitive regime since citizens are free to
\nchoose their place of treatment, healthcare migration is particularly rel…
View article: From contact coverage to effective coverage of community care for patients with severe mental disorders: A real-world investigation from Italy
From contact coverage to effective coverage of community care for patients with severe mental disorders: A real-world investigation from Italy Open
Objectives To measure the gap between contact and effective coverage of mental healthcare (MHC). Materials and methods 45,761 newly referred cases of depression, schizophrenia, bipolar disorder, and personality disorder from four Italian r…
View article: Inter-Regional Patients’ Migration for Hospital Orthopedic Intensive Rehabilitation: The Italian Experience
Inter-Regional Patients’ Migration for Hospital Orthopedic Intensive Rehabilitation: The Italian Experience Open
Background: Following the introduction of administrative federalism in the Italian National Health Service, inter-regional patients’ mobility has become increasingly relevant because, in addition to being an indirect index of the quality o…
View article: Patients’ migration for orthopaedic intensive rehabilitation among Italian Regions
Patients’ migration for orthopaedic intensive rehabilitation among Italian Regions Open
Background Interregional patients’ migration, according to Italian Law, can be considered an expression of the (inviolable?) right to health and freedom of choice regarding place of care. It contributing, albeit perversely, to guaranteeing…
View article: Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders. Open
Gastrointestinal motility is tightly regulated by the enteric nervous system (ENS). Disruption of coordinated ENS activity can result in dysmotility. Pharmacological treatment options for dysmotility include targeting of G protein-coupled …
View article: Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia
Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia Open
This upload is associated with the software, Gut Analysis Toolbox (GAT). It contains StarDist models for segmenting enteric neurons in 2D, enteric neuronal subtypes in 2D and UNet model for enteric ganglia in 2D in gut wholemount tissue. G…
View article: Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia
Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia Open
This upload is associated with the software, Gut Analysis Toolbox (GAT). If you use it please cite: Sorensen et al. Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons. J Cell Sci 2024; jcs.261950. doi: https://doi.or…
View article: COVID-19 response: effectiveness of weekly rapid risk assessments, Italy
COVID-19 response: effectiveness of weekly rapid risk assessments, Italy Open
Although the system worked well, framing the risk assessment tool in a legal decree hampered its flexibility, as indicators could not be changed without changing the law. The relative complexity of the tool, the impossibility of real-time …
View article: Sustainable Well-Lighting Design for Cultural Heritage. Natural Light Control by Biological Elements and Digital Technologies
Sustainable Well-Lighting Design for Cultural Heritage. Natural Light Control by Biological Elements and Digital Technologies Open
The aim of our research was to define a methodological approach useful for sustainable lighting design, vision and perception quality, new visual paths and perceptive emotional experiences, in historic building. Ermanno Scervino’s boutique…