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View article: Pain Assessment and Management in Oncological Practice: A Survey from the Italian Network of Supportive Care in Oncology
Pain Assessment and Management in Oncological Practice: A Survey from the Italian Network of Supportive Care in Oncology Open
Background/Objectives: Cancer pain is prevalent across all stages of the disease, significantly impacting patients’ lives. Despite the availability of guidelines, its assessment and management remain suboptimal in many clinical settings. T…
View article: Comparison of NRS-2002 and MST nutritional screening and correlation with quality of life items in lung cancer patients (REAL-TIME observation study)
Comparison of NRS-2002 and MST nutritional screening and correlation with quality of life items in lung cancer patients (REAL-TIME observation study) Open
Purpose Approximately a 70% of lung cancer (LC) patients experience malnutrition. Therefore, a rapid and functional nutritional assessment is needed. Several nutritional screening instruments are available for clinical use. This study aime…
View article: 91P Observational retro-prospective study on immune checkpoint inhibitors (ICIs) treatment duration in patients with advanced non-small cell lung cancer (aNSCLC) (I-STOP study)
91P Observational retro-prospective study on immune checkpoint inhibitors (ICIs) treatment duration in patients with advanced non-small cell lung cancer (aNSCLC) (I-STOP study) Open
Data on optimal ICI treatment duration in aNSCLC are scarce, especially in real-world (RW) settings. I-STOP is an ongoing observational, multicentre, retro-prospective study looking at aNSCLC patients (pts) treated with single-agent ICI fo…
View article: Pleural empyema due to Salmonella enterica in a patient affected by lung adenocarcinoma: A clinical case report
Pleural empyema due to Salmonella enterica in a patient affected by lung adenocarcinoma: A clinical case report Open
During last years, lung cancer treatment has rapidly changed thanks to novel drugs, such as immunotherapy and target therapy. Hence, an improvement of life expectancy, notwithstanding with a higher infectious risk. This is probably due to …
View article: Exploratory analysis of the effect of a dexamethasone-sparing regimen for prophylaxis of cisplatin-induced emesis on food intake (LUNG-NEPA study)
Exploratory analysis of the effect of a dexamethasone-sparing regimen for prophylaxis of cisplatin-induced emesis on food intake (LUNG-NEPA study) Open
We demonstrated the non-inferiority of a dexamethasone (DEX)-sparing (single-dose) regimen with NEPA, a netupitant/palonosetron fixed combination, for preventing chemotherapy-induced nausea and vomiting (CINV) caused by cisplatin. This pre…
View article: Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer
Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer Open
Background: Lung cancer (LC) tissue for immunological characterization is often scarce. We explored and compared T cell characteristics between broncho-alveolar lavage from tumor affected (t-BAL) and contralateral lung (cl-BAL), with match…
View article: COVID-19 Contamination in Hospital Staff: Determinism, Epidemiological Features
COVID-19 Contamination in Hospital Staff: Determinism, Epidemiological Features Open
The first cases of SARS-CoV-2 were diagnosed in BENIN in early March 2020. Measures have been instituted to control its spread, including barrier measures. The objective of this study is to determine the effectiveness of self-application o…
View article: Knowledge, Perception and Attitude of Patients at CNHU-HKM of Cotonou About COVID-19
Knowledge, Perception and Attitude of Patients at CNHU-HKM of Cotonou About COVID-19 Open
COVID-19 has been noticed in Benin since March 2020. Various measures have been put in place to curb the epidemic. The objective of the study is to evaluate the knowledge and perception of patients at the CNHU-HKM about COVID-19. This was …
View article: SPECIAL ISSUE: INTIMACY AND SEXUALITY AFTER CANCER - How sexuality changes in women after cancer diagnosis
SPECIAL ISSUE: INTIMACY AND SEXUALITY AFTER CANCER - How sexuality changes in women after cancer diagnosis Open
Sexual dysfunctions are a common and unpleasant side effect in women cancer survivors that can drastically impair quality of life. The resources dedicated to evaluate and treat these dramatic sequalae are limited and scarcely known. Althou…
View article: SPECIAL ISSUE: INTIMACY AND SEXUALITY AFTER CANCER - Perception of sexuality disorders in cancer patients: A survey from italian healt providers
SPECIAL ISSUE: INTIMACY AND SEXUALITY AFTER CANCER - Perception of sexuality disorders in cancer patients: A survey from italian healt providers Open
Background Sexual dysfunction is a major health concern in cancer patients regardless of disease prognosis, with a negative impact on quality of life (QoL). Several studies reported a suboptimal sexual health assessment in cancer patients …
View article: ROC Analysis Identifies Baseline and Dynamic NLR and dNLR Cut-Offs to Predict ICI Outcome in 402 Advanced NSCLC Patients
ROC Analysis Identifies Baseline and Dynamic NLR and dNLR Cut-Offs to Predict ICI Outcome in 402 Advanced NSCLC Patients Open
Background: Neutrophil-to-Lymphocyte Ratio (NLR) and derived Neutrophils-to-(Leukocytes minus neutrophils) Ratio (dNLR) have been proposed as possible biomarkers of response to immune checkpoint inhibitors (ICI). However, in non-small cell…
View article: Early Progression in Non-Small Cell Lung Cancer (NSCLC) with High PD-L1 Treated with Pembrolizumab in First-Line Setting: A Prognostic Scoring System Based on Clinical Features
Early Progression in Non-Small Cell Lung Cancer (NSCLC) with High PD-L1 Treated with Pembrolizumab in First-Line Setting: A Prognostic Scoring System Based on Clinical Features Open
Background: Pembrolizumab is approved in monotherapy for the first-line (1L) of advanced or metastatic NSCLC patients with high PD-L1 (≥50%). Despite a proportion of patients achieve long-term survival, about one-third of patients experien…
View article: Dexamethasone-Sparing Regimens with Oral Netupitant and Palonosetron for the Prevention of Emesis Caused by High-Dose Cisplatin: A Randomized Noninferiority Study
Dexamethasone-Sparing Regimens with Oral Netupitant and Palonosetron for the Prevention of Emesis Caused by High-Dose Cisplatin: A Randomized Noninferiority Study Open
Background To reduce the overall exposure to dexamethasone (DEX) in patients receiving cisplatin-based chemotherapy, we evaluated the noninferiority of DEX on day 1, with or without low-dose DEX on days 2 and 3, combined with an oral fixed…
View article: PHYSICAL ACTIVITY (PA) AND LONG-TERM CANCER SURVIVORS: ITALIAN ASSOCIATION OF MEDICAL ONCOLOGY (AIOM)/SNLG GUIDELINES 2020
PHYSICAL ACTIVITY (PA) AND LONG-TERM CANCER SURVIVORS: ITALIAN ASSOCIATION OF MEDICAL ONCOLOGY (AIOM)/SNLG GUIDELINES 2020 Open
Purpose AIOM guidelines aimed to provide evidence-based answers to practical questions concerning the effects of PA on the health demands of long-term cancer survivors. If regular PA should be recommended to these patients, the best propos…
View article: ROC Analysis Identifies Baseline and Dynamic NLR and dNLR Cut-Offs to Predict ICI Outcome in 402 Advanced NSCLC Patients
ROC Analysis Identifies Baseline and Dynamic NLR and dNLR Cut-Offs to Predict ICI Outcome in 402 Advanced NSCLC Patients Open
Background: Neutrophil-to-Lymphocyte Ratio (NLR) and derived Neutrophils-to-(Leukocytes minus neutrophils) Ratio (dNLR) have been proposed as possible biomarkers of response to immune checkpoint inhibitors (ICI). However, in non-small cell…
View article: Clinicopathologic correlates of pembrolizumab efficacy in patients with advanced NSCLC and a PD-L1 expression of ≥ 50%
Clinicopathologic correlates of pembrolizumab efficacy in patients with advanced NSCLC and a PD-L1 expression of ≥ 50% Open
Background Single agent pembrolizumab represents the standard first line option for metastatic non-small-cell-lung-cancer (NSCLC) patients with a PD-L1 (programmed death-ligand 1) expression of ≥ 50%. Methods We conducted a multicenter stu…
View article: Symptomatic COVID-19 in advanced-cancer patients treated with immune-checkpoint inhibitors: prospective analysis from a multicentre observational trial by FICOG
Symptomatic COVID-19 in advanced-cancer patients treated with immune-checkpoint inhibitors: prospective analysis from a multicentre observational trial by FICOG Open
Background: This prospective, multicentre, observational INVIDIa-2 study is investigating the clinical efficacy of influenza vaccination in advanced-cancer patients receiving immune-checkpoint inhibitors (ICIs), enrolled in 82 Italian cent…
View article: Osimertinib-induced Cardiac Dysfunction in EGFR-Mutated Lung Cancer: A Case Series of Five Patients
Osimertinib-induced Cardiac Dysfunction in EGFR-Mutated Lung Cancer: A Case Series of Five Patients Open
Introduction : The gold standard treatment for Epidermal Growth Factor Receptor ( EGFR ) positive Non-Small Cell Lung Cancer (NSCLC)patients is represented byosimertinib, an irreversible third-generation EGFR inhibitor that has been p…