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View article: Pancreatitis Preceding the Diagnosis of IBD in Children: A Retrospective Observational Study
Pancreatitis Preceding the Diagnosis of IBD in Children: A Retrospective Observational Study Open
Background: Pancreatic involvement in inflammatory bowel diseases (IBD) is relatively common and includes a range of conditions, such as acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP), and pancreatic exoc…
View article: Innovative endoscopic alternatives for the conservative management of recurrent/refractory esophageal strictures in children: A case series
Innovative endoscopic alternatives for the conservative management of recurrent/refractory esophageal strictures in children: A case series Open
BACKGROUND Refractory esophageal strictures (ES) are defined an anatomical restriction without an active endoscopic inflammation resulting in dysphagia after a minimum of five seriated dilatations in a 4-weeks interval. Recurrent ES (REES)…
View article: Primary and Secondary Prophylaxis of Gastrointestinal Bleeding in Children with Portal Hypertension: A Multicenter National Study by SIGENP.
Primary and Secondary Prophylaxis of Gastrointestinal Bleeding in Children with Portal Hypertension: A Multicenter National Study by SIGENP. Open
Background/Objectives: Portal hypertension (PH) is a common complication in children with chronic liver diseases. Primary and secondary prophylaxis of variceal bleeding in these patients remains controversial. Our study aims to evaluate th…
View article: Risk scores for choledocholithiasis perform poorly in patients with hemolytic diseases: a PEDI database report
Risk scores for choledocholithiasis perform poorly in patients with hemolytic diseases: a PEDI database report Open
Patients with hemolytic diseases are at increased risk for gallstone-related complications. Modified scoring systems have been developed to assess which pediatric patients would benefit from endoscopic retrograde cholangiopancreatography (…
View article: Measurement of Anti-TNF Biologics in Serum Samples of Pediatric Patients: Comparison of Enzyme-Linked Immunosorbent Assay (ELISA) with a Rapid and Automated Fluorescence-Based Lateral Flow Immunoassay
Measurement of Anti-TNF Biologics in Serum Samples of Pediatric Patients: Comparison of Enzyme-Linked Immunosorbent Assay (ELISA) with a Rapid and Automated Fluorescence-Based Lateral Flow Immunoassay Open
Background: Therapeutic drug monitoring (TDM) of infliximab (IFX) and adalimumab (ADL) mainly relies on the use of enzyme-linked immunosorbent assays (ELISA). More recently, rapid assays have been developed and validated to reduce turnarou…
View article: Endoscopic retrograde cholangiopancreatography in children with pediatric congenital biliary dilatation associated with pancreatobiliary maljunction: experience from a tertiary center
Endoscopic retrograde cholangiopancreatography in children with pediatric congenital biliary dilatation associated with pancreatobiliary maljunction: experience from a tertiary center Open
Background Congenital biliary dilatation (CBD) is a congenital malformation of the main biliary tract usually associated with the pancreatobiliary maljunction (PBM), determining stone formation, cholangitis, pancreatitis, and cholangiocarc…
View article: Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children
Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children Open
What is Known Botulinum toxin (BoNT) causes muscle relaxation by inhibiting acetylcholine release from presynaptic motor neurons at the neuromuscular junction. What is New In children with achalasia, BoNT can be considered only in patients…
View article: Pharmacokinetic effects of endoscopic gastric decontamination for multidrug gastric pharmacobezoars
Pharmacokinetic effects of endoscopic gastric decontamination for multidrug gastric pharmacobezoars Open
Our case shows how GL is not effective in mitigating multidrug absorption especially drugs potentially inducing pharmacobezoars. Furthermore, based on our plasma drug monitoring, we believe that early EGD should be considered in all cases …
View article: Major Abdominal Surgery for Pediatric Crohn’s Disease in the Anti-TNF Era: 10-Year Analysis of Data From the IBD Registry of Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition
Major Abdominal Surgery for Pediatric Crohn’s Disease in the Anti-TNF Era: 10-Year Analysis of Data From the IBD Registry of Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition Open
Background The natural history of Crohn’s disease (CD) can result in complications requiring surgery. Pediatric data are scarce about major abdominal surgery. The IBD Registry from the Italian Society of Pediatric Gastroenterology, Hepatol…
View article: Pediatric ERCP in the Setting of Acute Pancreatitis
Pediatric ERCP in the Setting of Acute Pancreatitis Open
Previous studies have demonstrated the safety of performing endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population; however, few have addressed the outcomes of children undergoing ERCP during acute pancreatitis (…
View article: Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease
Efficacy and Tolerance of Thalidomide in Patients With Very Early Onset Inflammatory Bowel Disease Open
Background Few drugs have been studied for patients with very early onset inflammatory bowel disease (VEOIBD). This study aimed to evaluate the efficacy and tolerance of thalidomide in children with VEOIBD compared with children with pedia…
View article: New frontiers for therapeutic endoscopic ultrasound in children
New frontiers for therapeutic endoscopic ultrasound in children Open
Therapeutic endoscopic ultrasound is a well-established tool for several gastrointestinal disorders in adults. Diffusion in children is still limited but it can represent an effective, non-invasive option. A selection of relevant clinical …
View article: Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens
Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens Open
Patients affected by Inflammatory Bowel Disease (IBD) present higher risk for infection and suboptimal response upon vaccination. The immunogenicity of SARS-CoV2 vaccination is still largely unknown in adolescents or young adults affected …
View article: Duodenal Duplication Cysts in Children: Clinical Features and Current Treatment Choices
Duodenal Duplication Cysts in Children: Clinical Features and Current Treatment Choices Open
Background: Duodenal duplication cysts are rare gastrointestinal tract malformations. Most patients experience symptom onset in the first decade of life. This review aims to examine clinical presentation, management strategies and outcomes…
View article: Author Correction: The landscape of d16HER2 splice variant expression across HER2-positive cancers
Author Correction: The landscape of d16HER2 splice variant expression across HER2-positive cancers Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries
Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries Open
Background and Purpose: Early life microbiota plays a crucial role in human health by acting as a barrier from pathogens' invasion and maintaining the intestinal immune homoeostasis. Altered fecal microbiota (FM) ecology was reported in ne…
View article: Diagnostic Approach to Monogenic Inflammatory Bowel Disease in Clinical Practice: A Ten-Year Multicentric Experience
Diagnostic Approach to Monogenic Inflammatory Bowel Disease in Clinical Practice: A Ten-Year Multicentric Experience Open
Background and aims Multiple monogenic disorders present as very early onset inflammatory bowel disease (VEO-IBD) or as IBD with severe and atypical features. Establishing a genetic diagnosis may change patients’ management and prognosis. …
View article: P212 Diagnostic approach to monogenic inflammatory bowel disease in clinical practice: a 10-year multi-centric experience
P212 Diagnostic approach to monogenic inflammatory bowel disease in clinical practice: a 10-year multi-centric experience Open
Background and aims
\nMultiple monogenic disorders present as very early onset inflammatory bowel disease (VEO-IBD) or as IBD with severe and atypical features. Establishing a genetic diagnosis may change patients’ management and prognosis…
View article: <b>Intratumor lactate levels reflect HER2 addiction status in HER2‐positive breast cancer</b>
<b>Intratumor lactate levels reflect HER2 addiction status in HER2‐positive breast cancer</b> Open
Despite different molecular tumor profiles indicate that human epidermal growth factor receptor 2 (HER2) messenger RNA (mRNA) levels mirror HER2 addiction and trastuzumab benefit in HER2‐positive breast cancer (BC), the identification of n…
View article: Esophageal Retained Lithium Battery in Children Younger than 6 Years
Esophageal Retained Lithium Battery in Children Younger than 6 Years Open
Objectives Disk battery esophageal retention in children younger than 6 years represents an increasing endoscopic emergency, followed by a relevant risk of life-threatening late complications. Surgical removal after a failed endoscopic app…
View article: Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures
Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures Open
Improved surgical techniques, as well as preoperative and postoperative care, have dramatically changed survival of children with esophageal atresia (EA) over the last decades. Nowadays, we are increasingly seeing EA patients experiencing …
View article: An uncommon cause of abdominal pain in a child: Meckel diverticulum
An uncommon cause of abdominal pain in a child: Meckel diverticulum Open
Meckel diverticulum, a common congenital anomaly of the small intestine, can be responsible of several complications due to the presence of ectopic gastric mucosa and represents a challenge for diagnosis. We present the case of a 11-year b…