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View article: In vivo synergistic enhancement of <scp>MIF</scp> ‐mediated inflammation in acute lung injury by the plant ortholog <i>Arabidopsis</i> <scp>MDL1</scp>
In vivo synergistic enhancement of <span>MIF</span> ‐mediated inflammation in acute lung injury by the plant ortholog <i>Arabidopsis</i> <span>MDL1</span> Open
Recent research has uncovered Arabidopsis thaliana proteins that are similar to the human inflammatory cytokine MIF. Plant MIF/D‐dopachrome tautomerase (D‐DT)‐like proteins (MDLs) can interact with human MIF, yet the significance of these …
View article: Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells
Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells Open
Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory cytokines. Plants have orthologous MIF and D-dopachrome tautomerase–like (MDL) proteins that mimic some of t…
View article: The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia
The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia Open
Background: Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells characterized by their strong regenerative potential and low oxygen consumption. Macrophage migration inhibitory factor (MIF) is a multifunctional chemoki…
View article: Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting Open
Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging. Soluble receptor-based strategies are not established for chemokine receptors due to their discontinuous architecture. Macrophage migration-inhibitory fac…