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View article: High intensity interval training as a novel treatment for impaired awareness of hypoglycaemia in people with type 1 diabetes (HIT4HYPOS): a randomised parallel-group study
High intensity interval training as a novel treatment for impaired awareness of hypoglycaemia in people with type 1 diabetes (HIT4HYPOS): a randomised parallel-group study Open
Aims/hypothesis Impaired awareness of hypoglycaemia (IAH) in type 1 diabetes may develop through a process referred to as habituation. Consistent with this, a single bout of high intensity interval exercise as a novel stress stimulus impro…
View article: Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population
Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population Open
Background Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative stress is thought to capture most of the complexities involved in the …
View article: Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study
Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study Open
Objective To assess the real-world cardiovascular (CV) safety for SU, in comparison with dipeptidylpeptidase-4 inhibitors (DPP4i) and thiazolidinediones (TZD) through development of robust methodology for causal inference in a whole nati…
View article: Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study
Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study Open
Objective To assess the real-world cardiovascular (CV) safety for SU, in comparison with dipeptidylpeptidase-4 inhibitors (DPP4i) and thiazolidinediones (TZD) through development of robust methodology for causal inference in a whole nati…
View article: Cardiovascular Safety in Type 2 Diabetes With Sulfonylureas as Second-line Drugs: A Nationwide Population-Based Comparative Safety Study
Cardiovascular Safety in Type 2 Diabetes With Sulfonylureas as Second-line Drugs: A Nationwide Population-Based Comparative Safety Study Open
OBJECTIVE To assess the real-world cardiovascular (CV) safety for sulfonylureas (SU), in comparison with dipeptidyl peptidase 4 inhibitors (DPP4i) and thiazolidinediones (TZD), through development of robust methodology for causal inference…
View article: Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study
Cardiovascular safety in type 2 diabetes with sulfonylureas as second-line drugs: a nation-wide population based comparative safety study Open
Objective To assess the real-world cardiovascular (CV) safety for SU, in comparison with dipeptidylpeptidase-4 inhibitors (DPP4i) and thiazolidinediones (TZD) through development of robust methodology for causal inference in a whole nati…
View article: Glycated Haemoglobin A1c Variability Score Elicits Kidney Function Decline in Chinese People Living with Type 2 Diabetes
Glycated Haemoglobin A1c Variability Score Elicits Kidney Function Decline in Chinese People Living with Type 2 Diabetes Open
Our aim was to investigate the association of glycated haemoglobin A1c (HbA1c) variability score (HVS) with estimated glomerular filtration rate (eGFR) slope in Chinese adults living with type 2 diabetes. This cohort study included adults …
View article: Understanding health-care outcomes of older people with cognitive impairment and/or dementia admitted to hospital: a mixed-methods study
Understanding health-care outcomes of older people with cognitive impairment and/or dementia admitted to hospital: a mixed-methods study Open
Background Cognitive impairment is common in older people admitted to hospital, but previous research has focused on single conditions. Objective This project sits in phase 0/1 of the Medical Research Council Framework for the Development …
View article: The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study
The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study Open
Significance Statement Understanding of the interplay between AKI and CKD in people with type 2 diabetes, and how it compares with the interplay between AKI and CKD in the nondiabetic population, is limited. In this retrospective, cohort s…
View article: Real-time Continuous Glucose Monitoring During a Hyperinsulinemic-Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia
Real-time Continuous Glucose Monitoring During a Hyperinsulinemic-Hypoglycemic Clamp Significantly Underestimates the Degree of Hypoglycemia Open
First paragraph: Real-time continuous glucose monitoring (rtCGM) is increasingly used in patients with type 1 diabetes because it provides real-time data with low glucose alarms in place to alert individuals or their carers to developing h…
View article: P0578QUININE EXPOSURE AND THE RISK OF ACUTE KIDNEY INJURY: A POPULATION BASED OBSERVATIONAL STUDY OF OLDER PEOPLE
P0578QUININE EXPOSURE AND THE RISK OF ACUTE KIDNEY INJURY: A POPULATION BASED OBSERVATIONAL STUDY OF OLDER PEOPLE Open
Background and Aims Quinine can precipitate Acute Kidney Injury (AKI) by immune-mediated reactions. Cramps, for which quinine is traditionally prescribed, may be a symptom of conditions that are risk factors for AKI. The relationship betwe…
View article: Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people
Quinine exposure and the risk of acute kidney injury: a population-based observational study of older people Open
Objectives to establish and quantify any observable association between the exposure to community prescriptions for quinine and acute kidney injury (AKI) events in a population of older adults. Design two observational studies using the sa…
View article: Effect of multiple episodes of acute kidney injury on mortality: an observational study
Effect of multiple episodes of acute kidney injury on mortality: an observational study Open
Background Patients who survive an episode of acute kidney injury (AKI) are more likely to have further episodes of AKI. AKI is associated with increased mortality, with a further increase with recurrent episodes. It is not clear whether t…
View article: Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes
Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes Open
OBJECTIVE To investigate the association between visit-to-visit HbA1c variability and cardiovascular events and microvascular complications in patients with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS This retrospective co…
View article: Are antidementia drugs associated with reduced mortality after a hospital emergency admission in the population with dementia aged 65 years and older?
Are antidementia drugs associated with reduced mortality after a hospital emergency admission in the population with dementia aged 65 years and older? Open
Introduction People with dementia experience poor outcomes after hospital admission, with mortality being particularly high. There is no cure for dementia; antidementia medications have been shown to improve cognition and function, but the…
View article: Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 6,724 patients with 2 years follow-up
Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 6,724 patients with 2 years follow-up Open
Mortality post-admission is high in older people with CSD. Immediate risk is highest in those with delirium, while dementia or unspecified cognitive impairment is associated with medium- to long-term risk. These findings suggest that indiv…
View article: Emergent Properties of Microbial Activity in Heterogeneous Soil Microenvironments: Different Research Approaches Are Slowly Converging, Yet Major Challenges Remain
Emergent Properties of Microbial Activity in Heterogeneous Soil Microenvironments: Different Research Approaches Are Slowly Converging, Yet Major Challenges Remain Open
Over the last 60 years, soil microbiologists have accumulated a wealth of experimental data showing that the bulk, macroscopic parameters (e.g., granulometry, pH, soil organic matter, and biomass contents) commonly used to characterize soi…
View article: Texting to Reduce Alcohol Misuse (TRAM): main findings from a randomized controlled trial of a text message intervention to reduce binge drinking among disadvantaged men
Texting to Reduce Alcohol Misuse (TRAM): main findings from a randomized controlled trial of a text message intervention to reduce binge drinking among disadvantaged men Open
Aims To test the effectiveness of a theoretically based text‐message intervention to reduce binge drinking among socially disadvantaged men. Design A multi‐centre parallel group, pragmatic, individually randomized controlled trial. Setting…
View article: Malaria vectors resistance to commonly used insecticides in the control of malaria in Bichi, northern Nigeria
Malaria vectors resistance to commonly used insecticides in the control of malaria in Bichi, northern Nigeria Open
This study was carried out in 2015 to assess the level of resistance of sibling species of Anopheles gambiae complex the principal malaria vector from Bichi in Kano state to three classes of insecticides; (DDT, Permethrin and Bendiocarb) a…
View article: Uncovering behavioural diversity amongst high-strength Pseudomonas spp. surfactants at the limit of liquid surface tension reduction
Uncovering behavioural diversity amongst high-strength Pseudomonas spp. surfactants at the limit of liquid surface tension reduction Open
Bacterial biosurfactants have a wide range of biological functions and biotechnological applications. Previous analyses had suggested a limit to their reduction of aqueous liquid surface tensions (γMin), and here we confirm this in an anal…