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View article: An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia
An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia Open
Background Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19 + CD5 + B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5 + mature B cell …
View article: BAFF, but not APRIL, initiates Chronic Lymphocytic Leukemia by inducing tumor-promoting genes rather than cell survival.
BAFF, but not APRIL, initiates Chronic Lymphocytic Leukemia by inducing tumor-promoting genes rather than cell survival. Open
Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in adults, characterized by the expansion of CD19 + CD5 + B cells. The origin of CLL remains debated, with one model suggesting that CLL cells carrying mutations in the variabl…
View article: Molecular control of B‐cell homeostasis in health and malignancy
Molecular control of B‐cell homeostasis in health and malignancy Open
Altered B‐cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly …
View article: Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity
Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity Open
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as…