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View article: The emergence of electrical activity in human brain organoids
The emergence of electrical activity in human brain organoids Open
View article: Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency
Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency Open
Inborn errors of immunity (IEI), as congenital chronic disorders, are often associated with neurobehavioral symptoms, traditionally considered secondary to patient burden. Their origin, however, has yet to be addressed. Here, we found that…
View article: Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells
Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells Open
View article: Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions
Extracellular vesicles released by glioblastoma cancer cells drive tumor invasiveness via Connexin-43 gap junctions Open
Background Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only partially understood. Among the intrinsic and environmental processes promoting cell-to-cell …
View article: Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development Open
View article: Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot–Marie–Tooth type 2A
Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot–Marie–Tooth type 2A Open
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autosomal dominant mutations in the MFN2 gene cause Charcot–Marie–Tooth type 2A disease (CMT2A), a severe and disabling sen…
View article: MSIpixel: a fully automated pipeline for compound annotation and quantitation in mass spectrometry imaging experiments
MSIpixel: a fully automated pipeline for compound annotation and quantitation in mass spectrometry imaging experiments Open
Mass spectrometry imaging (MSI) is commonly used to map the spatial distribution of small molecules within complex biological matrices. One of the major challenges in imaging MS-based spatial metabolomics is molecular identification and me…
View article: Combined RNA interference and gene replacement therapy targeting MFN2 for the treatment of Charcot-Marie-Tooth type 2A
Combined RNA interference and gene replacement therapy targeting MFN2 for the treatment of Charcot-Marie-Tooth type 2A Open
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein essential for mitochondrial networking in most cells. Autosomal dominant mutations in the MFN2 gene cause Charcot-Marie-Tooth type 2A disease (CMT2A), a severe and disabling sen…
View article: Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex
Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex Open
View article: Dissecting cellular diversity of cortical GABAergic cells across multiple modalities: A turning point in neuronal taxonomy.
Dissecting cellular diversity of cortical GABAergic cells across multiple modalities: A turning point in neuronal taxonomy. Open
Decoding the complexity of the brain requires an understanding of the architecture, function, and development of its neuronal circuits. Neuronal classifications that group neurons based on specific features/behaviors have become essential …
View article: Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring Open
View article: Human-specific enrichment of schizophrenia risk-genes in callosal neurons of the developing neocortex
Human-specific enrichment of schizophrenia risk-genes in callosal neurons of the developing neocortex Open
Summary Human genetic studies have provided a wealth of information on genetic risk factors associated with neuropsychiatric diseases. However, whether different brain cell types are differentially affected in disease states and when in th…
View article: Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"
Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Open
This record contains raw data related to article “ Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Up to 40% of patients with inflammatory bowel disease (IBD) present disturbed psychosocial funct…
View article: Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"
Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Open
This record contains raw data related to article “ Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Up to 40% of patients with inflammatory bowel disease (IBD) present disturbed psychosocial funct…
View article: Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation"
Dataset related to article "Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Open
This record contains raw data related to article “" Identification of a Choroid Plexus Vascular Barrier Closing during Intestinal Inflammation" Up to 40% of patients with inflammatory bowel disease (IBD) present disturbed psychosocial func…
View article: Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants
Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants Open
View article: In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes Open
An in vivo analysis of autism risk genes CRISPR targeting in vivo, especially in mammals, can be difficult and time consuming when attempting to determine the effects of a single gene. However, such studies may be required to identify path…
View article: Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring
Transient Maternal IL-6 boosts glutamatergic synapses and disrupts hippocampal connectivity in the offspring Open
Summary Early prenatal inflammatory conditions are thought to represent a risk factor for different neurodevelopmental disorders, with long-term consequences on adult brain connectivity. Here we show that a transient IL-6 elevation, occurr…
View article: Temporally-Divergent Regulatory Mechanisms Govern Neuronal Development and Diversification in the Neocortex
Temporally-Divergent Regulatory Mechanisms Govern Neuronal Development and Diversification in the Neocortex Open
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. The regulatory strategies that neurons use during progressive development and maturation remain unclear. We present an integrated single-cell epige…
View article: Early Intervention in preterm infants modulates LINE-1 promoter methylation and neurodevelopment
Early Intervention in preterm infants modulates LINE-1 promoter methylation and neurodevelopment Open
Background Early life adversity exposure impacts preterm infants’ neurodevelopment and early intervention protocols may modulate neurodevelopmental outcomes. Neuronal genomes are plastic in response to environment and mobile genetic elemen…
View article: <i>In vivo</i> Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes
<i>In vivo</i> Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes Open
The thousands of disease risk genes and loci identified through human genetic studies far outstrip our current capacity to systematically study their functions. New experimental approaches are needed for functional investigations of large …
View article: Generating Neuronal Diversity in the Mammalian Cerebral Cortex
Generating Neuronal Diversity in the Mammalian Cerebral Cortex Open
The neocortex is the part of the brain responsible for execution of higher-order brain functions, including cognition, sensory perception, and sophisticated motor control. During evolution, the neocortex has developed an unparalleled neuro…