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Beyond the microscope: Unveiling bacterial vaginosis with <span>AI</span>‐powered multiomics data analysis Open
Recent advancements in production and access to large datasets, faster computing and cheaper storage have encouraged the development of machine learning (ML) algorithms with human-like artificial intelligence (AI) capabilities. Such algori…
Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease Open
Background Graft-versus-host disease (GvHD) is a major life-threatening complication of allogeneic haematopoietic stem cell transplantation (HSCT), limiting the broad application of HSCT for haematological malignancies. Cutaneous GvHD is d…
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
Raw microscopy images underlying the publication "Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation"
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
Raw microscopy images underlying the publication "Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation"
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
Granulomas are lumps of immune cells that can form in various organs. Most granulomas appear unstructured, yet they have some resemblance to lymphoid organs. To better understand granuloma formation, we performed single-cell sequencing and…
Processing human skin samples for single-cell assays Open
Characterizing resident immune cells in human skin using single-cell assays provides insight into their role in infections, inflammation, and cancer. We describe an optimized protocol to rapidly isolate viable cells from 6-mm skin punch-bi…
View article: Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
View article: Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
View article: Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
Interleukin‐33 improves local immunity during Gram‐negative pneumonia by a combined effect on neutrophils and inflammatory monocytes Open
Pneumonia represents a major health care burden and Gram‐negative bacteria provide an increasing therapeutic challenge at least in part through the emergence of multidrug‐resistant strains. IL‐33 is a multifunctional cytokine belonging to …
View article: Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls
Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls Open
Various autoantibodies are detected more frequently in HIV-infected individuals than in HIV-negative controls; however, limited data exist regarding autoimmune blistering skin diseases. Using enzyme-linked immunoassay (ELISA) and indirect …
View article: First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment Open
From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and infection. We investigated the homeostatic role of the epithelium-derived alarmi…