Simona Scheggi
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View article: EXPOSURE TO CHRONIC STRESS IMPAIRS MOTIVATION AND SOCIABILITY IN RATS: RESTORATIVE PROPERTIES OF CHRONIC LURASIDONE TREATMENT
EXPOSURE TO CHRONIC STRESS IMPAIRS MOTIVATION AND SOCIABILITY IN RATS: RESTORATIVE PROPERTIES OF CHRONIC LURASIDONE TREATMENT Open
Background Stress is one of the most important factors for the etiology of mental disorders. On these bases, exposure to stress is used to investigate neurobiological mechanisms associated with specific psychopathologic mechanisms and to e…
View article: Prefrontal 5α-reductase 2 mediates male-specific acute stress response
Prefrontal 5α-reductase 2 mediates male-specific acute stress response Open
A key response to acute stress is the increased brain synthesis of the neurosteroid allopregnanolone (AP). Although the rate-limiting step of this reaction is catalyzed by 5α-reductase (5αR), the role of its two primary isoenzymes, 5αR1 an…
View article: Restorative properties of chronic lurasidone treatment on emotional dysfunction in rats exposed to chronic unavoidable stress: A role for medial prefrontal cortex - nucleus accumbens network
Restorative properties of chronic lurasidone treatment on emotional dysfunction in rats exposed to chronic unavoidable stress: A role for medial prefrontal cortex - nucleus accumbens network Open
View article: Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans
Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans Open
Drugs generally used in major depressive disorder are considered inappropriate for the more common milder forms. The efficacy of saffron extracts has been demonstrated in mild to moderate depression and in preclinical models of depression.…
View article: Still controversial issues on assessing anhedonia in experimental modeling of depression
Still controversial issues on assessing anhedonia in experimental modeling of depression Open
View article: Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes
Expanding the therapeutic potential of neuro(active)steroids: a promising strategy for hyperdopaminergic behavioral phenotypes Open
View article: A Systematic Review on Ketamine and Esketamine for Treatment-Resistant Depression and Suicidality in Adolescents: A New Hope?
A Systematic Review on Ketamine and Esketamine for Treatment-Resistant Depression and Suicidality in Adolescents: A New Hope? Open
Treating depression in adolescents is a significant challenge, and major depressive disorder (MDD) with suicidal ideation and treatment-resistant depression (TRD) are common and potentially devastating to optimal psychological and physical…
View article: Prefrontal 5α-reductase 2 mediates male-specific acute stress response
Prefrontal 5α-reductase 2 mediates male-specific acute stress response Open
A key response to acute stress is the increased brain synthesis of the neurosteroid allopregnanolone (AP). While the rate-limiting step of this reaction is catalyzed by 5α-reductase (5αR), the role of its two primary isoenzymes, 5αR1 and 5…
View article: Exposure to social defeat stress impairs motivation and sociability in rats: restorative effects of chronic lurasidone treatment.
Exposure to social defeat stress impairs motivation and sociability in rats: restorative effects of chronic lurasidone treatment. Open
View article: Restorative properties of chronic lurasidone treatment on motivational dysfunction in rats exposed to chronic unavoidable stress
Restorative properties of chronic lurasidone treatment on motivational dysfunction in rats exposed to chronic unavoidable stress Open
View article: Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease Open
View article: Exposure to chronic unavoidable stress produces motivational anhedonia in rats: restorative properties of chronic lurasidone treatment
Exposure to chronic unavoidable stress produces motivational anhedonia in rats: restorative properties of chronic lurasidone treatment Open
View article: Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex
Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex Open
View article: Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals
Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals Open
View article: Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex
Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex Open
Background and purpose Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid…
View article: PPARα Signaling: A Candidate Target in Psychiatric Disorder Management
PPARα Signaling: A Candidate Target in Psychiatric Disorder Management Open
Peroxisome proliferator-activator receptors (PPARs) regulate lipid and glucose metabolism, control inflammatory processes, and modulate several brain functions. Three PPAR isoforms have been identified, PPARα, PPARβ/δ, and PPARγ, which are…
View article: The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting
The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting Open
View article: Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?
Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation? Open
The neurosteroid allopregnanolone (3α‐hydroxy‐5α‐pregnan‐20‐one; AP) elicits pleiotropic effects in the central nervous system, ranging from neuroprotective and anti‐inflammatory functions to the regulation of mood and emotional responses.…
View article: Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences Open
View article: The adverse effects of pramipexole on probability discounting are not reversed by acute D2 or D3 receptor antagonism
The adverse effects of pramipexole on probability discounting are not reversed by acute D2 or D3 receptor antagonism Open
View article: The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli
The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Open
Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. FIN is clinically a…
View article: Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation
Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation Open
View article: Noradrenergic terminals are the primary source of α2-adrenoceptor mediated dopamine release in the medial prefrontal cortex
Noradrenergic terminals are the primary source of α2-adrenoceptor mediated dopamine release in the medial prefrontal cortex Open
View article: Antidepressant and pro-motivational effects of repeated lamotrigine treatment in a rat model of depressive symptoms
Antidepressant and pro-motivational effects of repeated lamotrigine treatment in a rat model of depressive symptoms Open
This study shows antidepressant-like and pro-motivational effects of repeated lamotrigine administration in a rat model of depressive symptoms.
View article: 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction Open
View article: Making Sense of Rodent Models of Anhedonia
Making Sense of Rodent Models of Anhedonia Open
A markedly reduced interest or pleasure in activities previously considered pleasurable is a main symptom in mood disorder and psychosis and is often present in other psychiatric disorders and neurodegenerative diseases. This condition can…
View article: DARPP‐32 in the orchestration of responses to positive natural stimuli
DARPP‐32 in the orchestration of responses to positive natural stimuli Open
Dopamine‐ and cAMP‐regulated phosphoprotein (M r 32 kDa, DARPP‐32) is an integrator of multiple neuronal signals and plays a crucial role particularly in mediating the dopaminergic component of the systems involved in the evaluation of sti…
View article: The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation
The Neurosteroidogenic Enzyme 5α-Reductase Mediates Psychotic-Like Complications of Sleep Deprivation Open
View article: PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors
PPARα modulation of mesolimbic dopamine transmission rescues depression-related behaviors Open
View article: The protective effect of<i>Hypericum connatum</i>on stress-induced escape deficit in rat is related to its flavonoid content
The protective effect of<i>Hypericum connatum</i>on stress-induced escape deficit in rat is related to its flavonoid content Open
Context Hypericum perforatum L. (Hypericaceae), used in moderate depression treatment, is active in experimental tests for antidepressant activity. For H. connatum Lam., a South American species lacking hyperforin, antidepressant effects h…