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View article: From Microbiota to Cancer: Role of Extracellular Vesicles in Gut–Lung Axis
From Microbiota to Cancer: Role of Extracellular Vesicles in Gut–Lung Axis Open
Lung cancer (LC) remains the leading cause of cancer-related mortality worldwide, and resistance to therapy continues to pose a major clinical challenge. Increasing evidence highlights the relevance of the gut–lung axis in immune response …
View article: Hypoxia-Induced Extracellular Vesicles and Non-Coding RNAs in Cancer: A Systematic Review of Tumor Dynamics and Therapeutic Implications in Preclinical Animal Models
Hypoxia-Induced Extracellular Vesicles and Non-Coding RNAs in Cancer: A Systematic Review of Tumor Dynamics and Therapeutic Implications in Preclinical Animal Models Open
Background: Cancer is a heterogeneous pathology, and among causative factors, gene expression can influence its development. Molecular approaches using extracellular vesicles (EVs) and non-coding RNAs (ncRNAs) offer great value in understa…
View article: Effects of small extracellular vesicles isolated from pleural effusion on lung cancer cell proliferation and migration
Effects of small extracellular vesicles isolated from pleural effusion on lung cancer cell proliferation and migration Open
Pleural effusion (PE) is a common clinical manifestation associated with advanced stages of both malignant and non-malignant diseases. PE frequently occurs in advanced non-small cell lung cancer (NSCLC) and contributes to tumor progression…
View article: <i>Citrus</i> IntegroPectin bioconjugates induce apoptosis, decrease proliferation, reduce reactive oxygen species, alleviate mitochondrial oxidative stress, upregulate miR-146 expression and downregulate expression of Interleukin-8 in lung cancer cells
<i>Citrus</i> IntegroPectin bioconjugates induce apoptosis, decrease proliferation, reduce reactive oxygen species, alleviate mitochondrial oxidative stress, upregulate miR-146 expression and downregulate expression of Interleukin-8 in lung cancer cells Open
Tested on adenocarcinoma A549 cell line, IntegroPectin bioconjugates derived from the industrial processing waste of different organically grown Citrus fruits exert a pleiotropic activity in their anticancer mechanism by targeting differen…
View article: On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the <scp>LEXOVE</scp> prospective study
On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the <span>LEXOVE</span> prospective study Open
Extracellular vesicle (EV) monitoring can complement clinical assessment of cancer response. In this study, patients with advanced non‐small cell lung cancer (NSCLC) undergoing osimertinib, alectinib, pembrolizumab or platinum‐based chemot…
View article: Sea urchin immune cells and associated microbiota co-exposed to iron oxide nanoparticles activate cellular and molecular reprogramming that promotes physiological adaptation
Sea urchin immune cells and associated microbiota co-exposed to iron oxide nanoparticles activate cellular and molecular reprogramming that promotes physiological adaptation Open
The innate immune system is the first player involved in the recognition/interaction with nanomaterials. Still, it is not the only system involved. The co-evolution of the microbiota with the innate immune system built an interdependence r…
View article: Extracellular Vesicles: Diagnostic and Therapeutic Applications in Cancer
Extracellular Vesicles: Diagnostic and Therapeutic Applications in Cancer Open
In recent years, knowledge of cell-released extracellular vesicle (EV) functions has undergone rapid growth. EVs are membrane vesicles loaded with proteins, nucleic acids, lipids, and bioactive molecules. Once released into the extracellul…
View article: Extracellular Vesicles in Lung Cancer: Implementation in Diagnosis and Therapeutic Perspectives
Extracellular Vesicles in Lung Cancer: Implementation in Diagnosis and Therapeutic Perspectives Open
Lung cancer represents the leading cause of cancer-related mortality worldwide, with around 1.8 million deaths in 2020. For this reason, there is an enormous interest in finding early diagnostic tools and novel therapeutic approaches, one …
View article: On-treatment dynamics of circulating extracellular vesicles (EVs) in the first-line setting of patients with advanced non-small cell lung cancer (NSCLC): the LEXOVE prospective study
On-treatment dynamics of circulating extracellular vesicles (EVs) in the first-line setting of patients with advanced non-small cell lung cancer (NSCLC): the LEXOVE prospective study Open
Introduction: The evaluation of extracellular vesicles (EVs) might be a complementary tool to assess response in the clinic. We aimed to describe whether the serial characterization of EVs could longitudinally reflect response and resistan…
View article: PIWI-RNAs Small Noncoding RNAs with Smart Functions: Potential Theranostic Applications in Cancer
PIWI-RNAs Small Noncoding RNAs with Smart Functions: Potential Theranostic Applications in Cancer Open
P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a new class of small noncoding RNAs (ncRNAs) that bind components of the PIWI protein family. piRNAs are specifically expressed in different human tissues and regulate imp…
View article: Effects of condensates from volcanic fumaroles and cigarette smoke extracts on airway epithelial cells
Effects of condensates from volcanic fumaroles and cigarette smoke extracts on airway epithelial cells Open
The impact of volcanic airborne products on airway epithelium homeostasis is largely unknown. This study assessed the effects of volcanic Fumarole Condensates (FC) alone or combined with Cigarette Smoke Extracts (CSE) on airway epithelial …
View article: Data from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Data from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Because of the refractory nature of mutant KRAS lung adenocarcinoma (LUAD) to current therapies, identification of new molecular targets is essential. Genes with a prognostic role in mutant KRAS LUAD have proven to be potential molecular t…
View article: Supplementary Figure 4 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 4 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Regulation of kinases by Id1 expression
View article: Supplementary Figure 1 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 1 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Clinical implication of Id1 expression in LUAD patients.
View article: Supplementary Figure 4 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 4 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Regulation of kinases by Id1 expression
View article: Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
An Id1 gene signature is dependent of KEAP1-related genes and a FOSL1 network.
View article: Supplementary Information from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Information from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Supplementary tables and figure's headings
View article: Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
An Id1 gene signature is dependent of KEAP1-related genes and a FOSL1 network.
View article: Supplementary Information from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Information from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Supplementary tables and figure's headings
View article: Data from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Data from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Because of the refractory nature of mutant KRAS lung adenocarcinoma (LUAD) to current therapies, identification of new molecular targets is essential. Genes with a prognostic role in mutant KRAS LUAD have proven to be potential molecular t…
View article: Supplementary Figure 2 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 2 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
A shRNA-resistant Id1 cDNA rescues Id1 loss.
View article: Supplementary Figure 2 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 2 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
A shRNA-resistant Id1 cDNA rescues Id1 loss.
View article: Supplementary Figure 1 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network
Supplementary Figure 1 from Inhibitor of Differentiation-1 Sustains Mutant <i>KRAS</i>-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network Open
Clinical implication of Id1 expression in LUAD patients.
View article: Tyndallized Bacteria Preferentially Induce Human Macrophage M1 Polarization: An Effect Useful to Balance Allergic Immune Responses and to Control Infections
Tyndallized Bacteria Preferentially Induce Human Macrophage M1 Polarization: An Effect Useful to Balance Allergic Immune Responses and to Control Infections Open
Macrophage polarization is a dynamic process through which macrophages acquire specific features whose extremes are represented by M1 and M2 polarization. Interleukin (IL)-6, IL-1β, IL-12 and IL-8 belong to M1 macrophages while transformin…
View article: Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines
Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines Open
Lung cancer is one of the leading forms of cancer in developed countries. Interleukin-8 (IL-8), a pro-inflammatory cytokine, exerts relevant effects in cancer growth and progression, including angiogenesis and metastasis in lung cancer. Me…
View article: Extracellular Vesicles-ceRNAs as Ovarian Cancer Biomarkers: Looking into circRNA-miRNA-mRNA Code
Extracellular Vesicles-ceRNAs as Ovarian Cancer Biomarkers: Looking into circRNA-miRNA-mRNA Code Open
Ovarian cancer (OC) is one of the most lethal gynecologic malignancies in females worldwide. OC is frequently diagnosed at an advanced stage due to a lack of specific symptoms and effective screening tests, resulting in a poor prognosis fo…
View article: miR-126-3p and miR-21-5p as Hallmarks of Bio-Positive Ageing; Correlation Analysis and Machine Learning Prediction in Young to Ultra-Centenarian Sicilian Population
miR-126-3p and miR-21-5p as Hallmarks of Bio-Positive Ageing; Correlation Analysis and Machine Learning Prediction in Young to Ultra-Centenarian Sicilian Population Open
Human ageing can be characterized by a profile of circulating microRNAs (miRNAs), which are potentially predictors of biological age. They can be used as a biomarker of risk for age-related inflammatory outcomes, and senescent endothelial …
View article: Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers Open
Natural product research is a cornerstone of the architectural framework of clinical medicine. Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate diff…
View article: High Mobility Group Box 1: Biological Functions and Relevance in Oxidative Stress Related Chronic Diseases
High Mobility Group Box 1: Biological Functions and Relevance in Oxidative Stress Related Chronic Diseases Open
In the early 1970s, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and named high-mobility group (HMG) proteins. High-mobility group box 1 (HMGB1) is the most studied HMG protein that detects and …