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View article: Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn ( <scp> <i>Hippophae rhamnoides</i> </scp> L.) Extract in <scp>BT</scp> ‐549 Triple‐Negative Breast Cancer Cells
Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn ( <span> <i>Hippophae rhamnoides</i> </span> L.) Extract in <span>BT</span> ‐549 Triple‐Negative Breast Cancer Cells Open
Triple‐negative breast cancer (TNBC) is an aggressive subtype with high heterogeneity, metastasis, and drug resistance, underscoring the need for new therapeutic strategies. Sea buckthorn berries, long used in traditional medicine, are ric…
View article: The transcriptional landscape of cancer stem-like cell functionality in breast cancer
The transcriptional landscape of cancer stem-like cell functionality in breast cancer Open
Background Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack of specific molecular markers, increased phenotyp…
View article: The Bioactive Properties of Carotenoids from Lipophilic Sea buckthorn Extract (Hippophae rhamnoides L.) in Breast Cancer Cell Lines
The Bioactive Properties of Carotenoids from Lipophilic Sea buckthorn Extract (Hippophae rhamnoides L.) in Breast Cancer Cell Lines Open
In women, breast cancer is the most commonly diagnosed cancer (11.7% of total cases) and the leading cause of cancer death (6.9%) worldwide. Bioactive dietary components such as Sea buckthorn berries are known for their high carotenoid con…
View article: TFG Systematization process of generating semantic data and ontology
TFG Systematization process of generating semantic data and ontology Open
Set of TALIS files, the main source of data for the investigation, in CSV format.General ontology manually and by new software. Semantic data, as well as the DSL code. Finally, the web design of the new tool.
View article: TFG Systematization process of generating semantic data and ontology
TFG Systematization process of generating semantic data and ontology Open
Set of TALIS files, the main source of data for the investigation, in CSV format.General ontology manually and by new software. Semantic data, as well as the DSL code. Finally, the web design of the new tool.
View article: TFG Systematization process of generating semantic data and ontology
TFG Systematization process of generating semantic data and ontology Open
Set of TALIS files, the main source of data for the investigation, in CSV format.General ontology manually and by new software. Semantic data, as well as the DSL code. Finally, the web design of the new tool.
View article: Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients
Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients Open
Neo-adjuvant therapy (NAT) is increasingly used in the clinic for the treatment of breast cancer (BC). Pathological response to NAT has been associated with improved patients’ survival; however, the current techniques employed for assessin…
View article: The Role of miR-375-3p, miR-210-3p and Let-7e-5p in the Pathological Response of Breast Cancer Patients to Neoadjuvant Therapy
The Role of miR-375-3p, miR-210-3p and Let-7e-5p in the Pathological Response of Breast Cancer Patients to Neoadjuvant Therapy Open
Background and Objectives: Prediction of response to therapy remains a continuing challenge in treating breast cancer, especially for identifying molecular tissue markers that best characterize resistant tumours. Microribonucleic acids (mi…
View article: Influenza A, Influenza B, and SARS-CoV-2 Similarities and Differences – A Focus on Diagnosis
Influenza A, Influenza B, and SARS-CoV-2 Similarities and Differences – A Focus on Diagnosis Open
In late December 2019, the first cases of viral pneumonia caused by an unidentified pathogen were reported in China. Two years later, SARS-CoV-2 was responsible for almost 450 million cases, claiming more than 6 million lives. The COVID-19…
View article: Thyroid carcinoma associated with other primary neoplasms, a single center study
Thyroid carcinoma associated with other primary neoplasms, a single center study Open
Background and aims. Thyroid carcinoma is the most frequent endocrine malignancy. It develops following a complex interaction of environmental and genetic factors. Its incidence is on the rise mostly due to the frequent diagnosis of microc…
View article: Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients
Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients Open
MicroRNAs (miRNAs), a class of small non-coding RNAs represent potential biomarkers for colorectal cancer (CRC). The study hypothesized that miRNAs associated with liver metastases may also contribute to assessing treatment response when a…
View article: Critical Aspects Concerning the Development of a Pooling Approach for SARS-CoV-2 Diagnosis Using Large-Scale PCR Testing
Critical Aspects Concerning the Development of a Pooling Approach for SARS-CoV-2 Diagnosis Using Large-Scale PCR Testing Open
The primary approach to controlling the spread of the pandemic SARS-CoV-2 is to diagnose and isolate the infected people quickly. Our paper aimed to investigate the efficiency and the reliability of a hierarchical pooling approach for larg…
View article: TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis
TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis Open
Background: The complexity of myeloproliferative neoplasms (MPNs) cannot be characterized by acquired somatic mutations alone. Individual genetic background is thought to contribute to the development of MPNs. The aim of our study was to a…
View article: MiRNA-Based Therapeutics in Oncology, Realities, and Challenges
MiRNA-Based Therapeutics in Oncology, Realities, and Challenges Open
As master modulators of the human genome, miRNAs are involved in all cancer hallmarks, disrupting the normal function of their targets. By gaining or losing the function, miRNAs lead to the validation of tumor phenotype, its progression, a…
View article: The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases
The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases Open
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high incidence and mortality rate. An essential challenge in colorectal cancer management is to identify new prognostic factors that could better estimate th…
View article: Vitamin D receptor polymorphisms and melanoma (Review)
Vitamin D receptor polymorphisms and melanoma (Review) Open
Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates th…
View article: The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases<strong> </strong>
The Impact of miRNA in Colorectal Cancer Progression and Its Liver Metastases<strong> </strong> Open
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high incidence and mortality. An essential challenge in colorectal cancer management is to identify new prognostic factors that could better estimate the evo…
View article: <i>MECOM</i>, <i>HBS1L‐MYB</i>, <i>THRB‐RARB, JAK2</i>, and <i>TERT</i> polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients
<i>MECOM</i>, <i>HBS1L‐MYB</i>, <i>THRB‐RARB, JAK2</i>, and <i>TERT</i> polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients Open
Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are classical myeloproliferative neoplasms (MPN), characterized by specific somatic mutations in JAK2 , CALR or MPL genes. JAK2 46/1 and TERT rs2736100 …
View article: Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients
Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients Open
Tumors act systemically to sustain cancer progression, affecting the physiological processes in the host and triggering responses in the blood circulating cells. In this study, we explored blood transcriptional patterns of patients with tw…