Simone A. Evans
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Proteolytic activation of diverse antiviral defense modules in prokaryotes Open
Linked protease–effector modules are widespread in prokaryotic antiviral defense, yet the mechanisms of most remain poorly understood. Here we show that four of the most prevalent modules—metallo-β-lactamase (MBL)-fold hydrolase, α/β-hydro…
View article: p53 Drives Lung Cancer Regression through a TSC2/TFEB-Dependent Senescence Program
p53 Drives Lung Cancer Regression through a TSC2/TFEB-Dependent Senescence Program Open
Pharmacologic restoration of p53 tumor suppressor function is a conceptually appealing therapeutic strategy for the many deadly cancers with compromised p53 activity, including lung adenocarcinoma. However, the p53 pathway has remained und…
View article: Hybridization in the Fringed Orchids: An Analysis of Species Boundaries in the Face of Gene Flow
Hybridization in the Fringed Orchids: An Analysis of Species Boundaries in the Face of Gene Flow Open
Natural hybridization between closely related species in sympatry is an evolutionary process that is common in orchids. Once seen as a threat to parent species, interspecific genetic change is increasingly viewed as a source of novel varia…