Simone Adinolfi
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View article: Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells Open
The Kelch-like ECH-associated protein 1 (KEAP1) - Nuclear factor erythroid 2 -related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently const…
View article: Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells Open
The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2-related factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 is frequently consti…
View article: The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
The KEAP1-NRF2 pathway: Targets for therapy and role in cancer Open
The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well app…
View article: <scp>PI3Kβ</scp> inhibition enhances <scp>ALK</scp> ‐inhibitor sensitivity in <scp> <i>ALK</i> </scp> ‐rearranged lung cancer
<span>PI3Kβ</span> inhibition enhances <span>ALK</span> ‐inhibitor sensitivity in <span> <i>ALK</i> </span> ‐rearranged lung cancer Open
Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK ‐rearranged tumors. However, clinical resistance typically develops over time and, in the ma…
View article: PI3Kβ inhibition restores ALK inhibitor sensitivity in ALK-rearranged lung cancer
PI3Kβ inhibition restores ALK inhibitor sensitivity in ALK-rearranged lung cancer Open
For non-small cell lung cancer (NSCLC) patients with ALK -rearranged tumors, treatment with ALK inhibitors can improve outcomes. However, clinical resistance typically develops over time, and in the majority of cases resistance mechanisms …
View article: Regulation of stress signaling pathways by protein lipoxidation
Regulation of stress signaling pathways by protein lipoxidation Open
Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive species that covalently modify nucleophilic residues within redox sensitive protein sensors in a process called lipoxidation. This triggers adaptive si…
View article: Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy
Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy Open
View article: Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice Open
Aims Oxidative stress and inflammation play an important role in the progression of atherosclerosis. Transcription factor NF-E2-related factor 2 (Nrf2) has antioxidant and anti-inflammatory effects in the vessel wall, but paradoxically, gl…