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View article: Patient-Centric Long-Acting Injectable and Implantable Platforms─An Industrial Perspective
Patient-Centric Long-Acting Injectable and Implantable Platforms─An Industrial Perspective Open
[Image: see text] The increasing focus on patient centricity in the pharmaceutical industry over the past decade and the changing healthcare landscape, driven by factors such as increased access to information, social media, and evolving p…
View article: A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles
A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles Open
An α particle-emitting nanodrug that is a potent and specific antitumor agent and also prompts significant remodeling of local immunity in the tumor microenvironment (TME) has been developed and may impact the treatment of melanoma. Biocom…
View article: Carbon nanotubes exhibit fibrillar pharmacology in primates
Carbon nanotubes exhibit fibrillar pharmacology in primates Open
Nanomedicine rests at the nexus of medicine, bioengineering, and biology with great potential for improving health through innovation and development of new drugs and devices. Carbon nanotubes are an example of a fibrillar nanomaterial poi…
View article: Deconvoluting hepatic processing of carbon nanotubes
Deconvoluting hepatic processing of carbon nanotubes Open
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidat…
View article: Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury
Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury Open
Fibrillar carbon nanotubes simultaneously deliver two small interfering RNAs, which safely prevent acute kidney injury and prolong survival in mice.