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View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. …
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility.…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function
Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function Open
BackgroundNeutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. T…
View article: Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence Open
Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocyto…
View article: Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle
Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle Open
Neutrophils are predominantly glycolytic cells that derive little ATP from oxidative phosphorylation; however, they possess an extensive mitochondrial network and maintain a mitochondrial membrane potential. Although studies have shown neu…
View article: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS Open
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils p…
View article: Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis Open
sponsorship: Academy of Medical Sciences (AMS)|AMS-SGCL11-Thompson, British Heart Foundation|FS/18/13/33281, Medical Research Council|MR/N02995X/1, Medical Research Council|MC_PC_U127574433, MRC|MR/N02995X/1
View article: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS Open
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils pl…
View article: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS Open
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a…
View article: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS Open
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a…
View article: A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS Open
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a…
View article: Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis Open
Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophi…
View article: Proteomics identifies a type I IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS
Proteomics identifies a type I IFN, prothrombotic hyperinflammatory circulating COVID-19 neutrophil signature distinct from non-COVID-19 ARDS Open
Summary Understanding the mechanisms by which infection with SARS-CoV-2 leads to acute respiratory distress syndrome (ARDS) is of significant clinical interest given the mortality associated with severe and critical coronavirus induced dis…
View article: Regulation of Apoptotic Cell Clearance During Resolution of Inflammation
Regulation of Apoptotic Cell Clearance During Resolution of Inflammation Open
Programmed cell death (apoptosis) has an important role in the maintenance of tissue homeostasis as well as the progression and ultimate resolution of inflammation. During apoptosis, the cell undergoes morphological and biochemical changes…